Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149687593> ?p ?o ?g. }
- W2149687593 endingPage "628" @default.
- W2149687593 startingPage "615" @default.
- W2149687593 abstract "A Cre/lox-conditional mouse line was generated to evaluate the role of ATR in checkpoint responses to ionizing radiation (IR) and stalled DNA replication. We demonstrate that after IR treatment, ATR and ATM each contribute to early delay in M-phase entry but that ATR regulates a majority of the late phase (2-9 h post-IR). Double deletion of ATR and ATM eliminates nearly all IR-induced delay, indicating that ATR and ATM cooperate in the IR-induced G2/M-phase checkpoint. In contrast to the IR-induced checkpoint, checkpoint delay in response to stalled DNA replication is intact in ATR knockout cells and ATR/ATM and ATR/p53 double-knockout cells. The DNA replication checkpoint remains intact in ATR knockout cells even though the checkpoint-stimulated inhibitory phosphorylation of Cdc2 on T14/Y15 and activating phosphorylation of the Chk1 kinase no longer occur. Thus, incomplete DNA replication in mammalian cells can prevent M-phase entry independently of ATR and inhibitory phosphorylation of Cdc2. When DNA replication inhibitors are removed, ATR knockout cells proceed to mitosis but do so with chromosome breaks, indicating that ATR provides a key genome maintenance function in S phase." @default.
- W2149687593 created "2016-06-24" @default.
- W2149687593 creator A5042763205 @default.
- W2149687593 creator A5083894198 @default.
- W2149687593 date "2003-02-19" @default.
- W2149687593 modified "2023-10-15" @default.
- W2149687593 title "Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance" @default.
- W2149687593 cites W1498525243 @default.
- W2149687593 cites W1570361288 @default.
- W2149687593 cites W1752089945 @default.
- W2149687593 cites W1853857034 @default.
- W2149687593 cites W1965461792 @default.
- W2149687593 cites W1966219754 @default.
- W2149687593 cites W1966725512 @default.
- W2149687593 cites W1968552183 @default.
- W2149687593 cites W1970993216 @default.
- W2149687593 cites W1979015046 @default.
- W2149687593 cites W1985775217 @default.
- W2149687593 cites W1988876917 @default.
- W2149687593 cites W1998129814 @default.
- W2149687593 cites W2000303122 @default.
- W2149687593 cites W2005284058 @default.
- W2149687593 cites W2019405732 @default.
- W2149687593 cites W2037174767 @default.
- W2149687593 cites W2037728125 @default.
- W2149687593 cites W2046049550 @default.
- W2149687593 cites W2049508647 @default.
- W2149687593 cites W2050608484 @default.
- W2149687593 cites W2055157702 @default.
- W2149687593 cites W2057106513 @default.
- W2149687593 cites W2069259673 @default.
- W2149687593 cites W2084969545 @default.
- W2149687593 cites W2088529761 @default.
- W2149687593 cites W2088740611 @default.
- W2149687593 cites W2090450165 @default.
- W2149687593 cites W2105592350 @default.
- W2149687593 cites W2108547322 @default.
- W2149687593 cites W2109805150 @default.
- W2149687593 cites W2111403239 @default.
- W2149687593 cites W2112481873 @default.
- W2149687593 cites W2116468279 @default.
- W2149687593 cites W2119999819 @default.
- W2149687593 cites W2127849733 @default.
- W2149687593 cites W2133291090 @default.
- W2149687593 cites W2133318290 @default.
- W2149687593 cites W2133643647 @default.
- W2149687593 cites W2137249911 @default.
- W2149687593 cites W2154141161 @default.
- W2149687593 cites W2154853638 @default.
- W2149687593 cites W2155640249 @default.
- W2149687593 cites W2155953141 @default.
- W2149687593 cites W2167196101 @default.
- W2149687593 cites W54191497 @default.
- W2149687593 doi "https://doi.org/10.1101/gad.1067403" @default.
- W2149687593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/196009" @default.
- W2149687593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12629044" @default.
- W2149687593 hasPublicationYear "2003" @default.
- W2149687593 type Work @default.
- W2149687593 sameAs 2149687593 @default.
- W2149687593 citedByCount "466" @default.
- W2149687593 countsByYear W21496875932012 @default.
- W2149687593 countsByYear W21496875932013 @default.
- W2149687593 countsByYear W21496875932014 @default.
- W2149687593 countsByYear W21496875932015 @default.
- W2149687593 countsByYear W21496875932016 @default.
- W2149687593 countsByYear W21496875932017 @default.
- W2149687593 countsByYear W21496875932018 @default.
- W2149687593 countsByYear W21496875932019 @default.
- W2149687593 countsByYear W21496875932020 @default.
- W2149687593 countsByYear W21496875932021 @default.
- W2149687593 countsByYear W21496875932022 @default.
- W2149687593 countsByYear W21496875932023 @default.
- W2149687593 crossrefType "journal-article" @default.
- W2149687593 hasAuthorship W2149687593A5042763205 @default.
- W2149687593 hasAuthorship W2149687593A5083894198 @default.
- W2149687593 hasBestOaLocation W21496875931 @default.
- W2149687593 hasConcept C105696609 @default.
- W2149687593 hasConcept C134935766 @default.
- W2149687593 hasConcept C143425029 @default.
- W2149687593 hasConcept C1491633281 @default.
- W2149687593 hasConcept C29537977 @default.
- W2149687593 hasConcept C50001416 @default.
- W2149687593 hasConcept C54086632 @default.
- W2149687593 hasConcept C54355233 @default.
- W2149687593 hasConcept C552990157 @default.
- W2149687593 hasConcept C73573662 @default.
- W2149687593 hasConcept C86803240 @default.
- W2149687593 hasConcept C93304396 @default.
- W2149687593 hasConcept C95444343 @default.
- W2149687593 hasConceptScore W2149687593C105696609 @default.
- W2149687593 hasConceptScore W2149687593C134935766 @default.
- W2149687593 hasConceptScore W2149687593C143425029 @default.
- W2149687593 hasConceptScore W2149687593C1491633281 @default.
- W2149687593 hasConceptScore W2149687593C29537977 @default.
- W2149687593 hasConceptScore W2149687593C50001416 @default.
- W2149687593 hasConceptScore W2149687593C54086632 @default.
- W2149687593 hasConceptScore W2149687593C54355233 @default.
- W2149687593 hasConceptScore W2149687593C552990157 @default.