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- W2149696364 abstract "Spitzoid melanoma in children is a rare tumor that can mimic Spitz nevus both clinically and histologically. Recently, dysregulation of the RAS-RAF-MAPK signalling pathway was reported in 89% of sporadic melanomas due to activating mutations in the BRAF or NRAS gene. BRAF mutations are found in 53–80% of primary melanomas and 70–90% of common melanocytic nevi, whereas none are present in Spitz nevi. NRAS mutations occur in 5–37% of melanomas and 9–56% of common melanocytic nevi. The mutational status of NRAS in Spitz nevi is unknown. This is the first study analyzing the mutational profile of BRAF and NRAS in Spitzoid melanomas occurring in prepubertal children (10 years of age or younger). Primary tumor cells were isolated via laser capture microdissection from 10 typical Spitz nevi and 10 metastatic Spitzoid melanomas. Exons 11 and 15 of BRAF and exons 2 and 3 of NRAS were amplified by PCR and directly sequenced. Common activating mutations were not identified in BRAF or NRAS. Absence of the V599E hot-spot mutation in BRAF was further confirmed by allele-specific PCR. We conclude that Spitzoid melanomas in children share clinical, histological and genetic similarities to Spitz nevi, and are genetically distinct from other melanoma subtypes." @default.
- W2149696364 created "2016-06-24" @default.
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- W2149696364 date "2008-06-28" @default.
- W2149696364 modified "2023-09-25" @default.
- W2149696364 title "Spitzoid Melanomas in Children, Like Spitz Nevi, Lack Common Activating Mutations in BRAF and NRAS" @default.
- W2149696364 doi "https://doi.org/10.1111/j.0303-6987.2005.320cd.x" @default.
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