FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149703418> ?p ?o ?g. }

• W2149703418 endingPage "562" @default.
• W2149703418 startingPage "553" @default.
• W2149703418 abstract "Dendritic cells (DC) are regarded as the 'sentinels' of the immune system. They play a crucial role in surveillance of peripheral tissues, trapping antigens encountered there, and migrating via the lymphatics to lymphoid organs where they interact with naive T cells thus generating antigen-specific primary immune responses. Until now it has been assumed DC are largely absent from the brain, meninges, and the choroid plexus within the ventricles. Such a situation was thought to partly explain the 'immune privileged' nature of the central nervous system (CNS). The present study of normal rat tissues using single and double immunohistochemistry reveals for the first time that extensive networks of major histocompatability (MHC) class II+/OX62+ DC are widely distributed in sites which may potentially encounter CNS antigens. These sites included the dura mater, leptomeninges, and the choroid plexus. These putative DC were negative when stained with the anti-resident tissue macrophage monoclonal antibody ED2. In addition to the rich networks of DC, dense populations of resident tissue macrophages (ED2+ and ED1+) were also demonstrated in the dura mater, leptomeninges and to a lesser extent in the choroid plexus. The presence of rich networks of DC and macrophages in the vascular and supporting tissues of the brain may play an important role in inflammatory and immune-mediated disorders affecting the CNS, including auto-immune demyelinating diseases such as multiple sclerosis. J. Comp. Neurol. 405:553–562, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2149703418 created "2016-06-24" @default.
• W2149703418 creator A5055760543 @default.
• W2149703418 date "1999-03-22" @default.
• W2149703418 modified "2023-10-02" @default.
• W2149703418 title "Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations" @default.
• W2149703418 cites W1641259203 @default.
• W2149703418 cites W190174392 @default.
• W2149703418 cites W1969581694 @default.
• W2149703418 cites W1977945339 @default.
• W2149703418 cites W1982120546 @default.
• W2149703418 cites W1996426015 @default.
• W2149703418 cites W2006084227 @default.
• W2149703418 cites W2010350911 @default.
• W2149703418 cites W2012037204 @default.
• W2149703418 cites W2013183815 @default.
• W2149703418 cites W2030943675 @default.
• W2149703418 cites W2033700934 @default.
• W2149703418 cites W2044585387 @default.
• W2149703418 cites W2046026976 @default.
• W2149703418 cites W2047226380 @default.
• W2149703418 cites W2047705892 @default.
• W2149703418 cites W2048275998 @default.
• W2149703418 cites W2050707975 @default.
• W2149703418 cites W2060411925 @default.
• W2149703418 cites W2062107675 @default.
• W2149703418 cites W2065700273 @default.
• W2149703418 cites W2066599974 @default.
• W2149703418 cites W2072384106 @default.
• W2149703418 cites W2076407459 @default.
• W2149703418 cites W2081110585 @default.
• W2149703418 cites W2094008496 @default.
• W2149703418 cites W2097417855 @default.
• W2149703418 cites W2099450563 @default.
• W2149703418 cites W2101186488 @default.
• W2149703418 cites W2109389149 @default.
• W2149703418 cites W2109416572 @default.
• W2149703418 cites W2112026930 @default.
• W2149703418 cites W2118075416 @default.
• W2149703418 cites W2119359657 @default.
• W2149703418 cites W2133622312 @default.
• W2149703418 cites W2177327503 @default.
• W2149703418 cites W2308181741 @default.
• W2149703418 doi "https://doi.org/10.1002/(sici)1096-9861(19990322)405:4<553::aid-cne8>3.0.co;2-6" @default.
• W2149703418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10098945" @default.
• W2149703418 hasPublicationYear "1999" @default.
• W2149703418 type Work @default.
• W2149703418 sameAs 2149703418 @default.
• W2149703418 citedByCount "295" @default.
• W2149703418 countsByYear W21497034182012 @default.
• W2149703418 countsByYear W21497034182013 @default.
• W2149703418 countsByYear W21497034182014 @default.
• W2149703418 countsByYear W21497034182015 @default.
• W2149703418 countsByYear W21497034182016 @default.
• W2149703418 countsByYear W21497034182017 @default.
• W2149703418 countsByYear W21497034182018 @default.
• W2149703418 countsByYear W21497034182019 @default.
• W2149703418 countsByYear W21497034182020 @default.
• W2149703418 countsByYear W21497034182021 @default.
• W2149703418 countsByYear W21497034182022 @default.
• W2149703418 countsByYear W21497034182023 @default.
• W2149703418 crossrefType "journal-article" @default.
• W2149703418 hasAuthorship W2149703418A5055760543 @default.
• W2149703418 hasConcept C105702510 @default.
• W2149703418 hasConcept C142724271 @default.
• W2149703418 hasConcept C147483822 @default.
• W2149703418 hasConcept C169760540 @default.
• W2149703418 hasConcept C181152851 @default.
• W2149703418 hasConcept C202751555 @default.
• W2149703418 hasConcept C203014093 @default.
• W2149703418 hasConcept C2776403516 @default.
• W2149703418 hasConcept C2776538271 @default.
• W2149703418 hasConcept C2776914184 @default.
• W2149703418 hasConcept C2777619780 @default.
• W2149703418 hasConcept C2778987889 @default.
• W2149703418 hasConcept C2779244956 @default.
• W2149703418 hasConcept C2779265215 @default.
• W2149703418 hasConcept C2779830541 @default.
• W2149703418 hasConcept C2910351856 @default.
• W2149703418 hasConcept C529278444 @default.
• W2149703418 hasConcept C55493867 @default.
• W2149703418 hasConcept C71924100 @default.
• W2149703418 hasConcept C86803240 @default.
• W2149703418 hasConcept C8891405 @default.
• W2149703418 hasConceptScore W2149703418C105702510 @default.
• W2149703418 hasConceptScore W2149703418C142724271 @default.
• W2149703418 hasConceptScore W2149703418C147483822 @default.
• W2149703418 hasConceptScore W2149703418C169760540 @default.
• W2149703418 hasConceptScore W2149703418C181152851 @default.
• W2149703418 hasConceptScore W2149703418C202751555 @default.
• W2149703418 hasConceptScore W2149703418C203014093 @default.
• W2149703418 hasConceptScore W2149703418C2776403516 @default.
• W2149703418 hasConceptScore W2149703418C2776538271 @default.
• W2149703418 hasConceptScore W2149703418C2776914184 @default.
• W2149703418 hasConceptScore W2149703418C2777619780 @default.
• W2149703418 hasConceptScore W2149703418C2778987889 @default.
• W2149703418 hasConceptScore W2149703418C2779244956 @default.
• W2149703418 hasConceptScore W2149703418C2779265215 @default.

• next