Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149703678> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2149703678 endingPage "1071" @default.
- W2149703678 startingPage "1068" @default.
- W2149703678 abstract "The pathogenesis of acute otitis media is complex and multifactorial. It is characterized by inflammation of the middle ear with an infiltration of leukocytes, macrophages and mast cells. The resulting effusion contains a large amount of inflammatory mediators, among which are cytokines.To test the role of IL-6 in the inflammatory process associated with acute otitis media.We analyzed 20 middle ear fluid (MEF) sample pairs, obtained by aspiration before initiating antibiotic therapy (day 1) and during treatment (days 4-5), for the presence of IL-6. IL-6 concentrations were assayed with an ELISA kit (detection limit 5 pg/ml) and were correlated with bacterial etiology and bacterial eradication from the middle ear.IL-6 was detected in all middle ear effusions analyzed. We found decreased IL-6 concentrations in culture negative MEF compared to culture positive MEF on both days I and 4-5 (day 1, 1752.20+/-1001.31 pg/ml vs 1216.20+/-1015.44 pg/ml, p = 0.19; days 4-5, 1049.36+/-472.40 pg/ml vs 800.33+/-676.00 pg/ml, p = 0.23); however, differences did not achieve statistical significance. Overall, a marked and significant decrease in IL-6 concentration occurred following 72-96 h of antibiotic therapy (1618.15+/-1004.88 pg/ml vs 936.85+/-581.05 pg/ml, p = 0.04). While MEF IL-6 concentrations decreased in ears where bacteria persisted (1468.20+/-858.48 pg/ml vs 1044.80+/-514.16 pg/ml, p = 0.167) or were eradicated (2320.20+/-866.16 pg/ml vs 767.40+/-522.88 pg/ml, p = 0.029), a more prominent decline was demonstrated in the latter.These results strongly suggest the involvement of IL-6 in the ongoing inflammatory process in both bacterial and non-bacterial acute otitis media. Resolution of inflammation in the middle ear, especially where bacteria were eradicated, is reflected by low IL-6 levels." @default.
- W2149703678 created "2016-06-24" @default.
- W2149703678 creator A5050824632 @default.
- W2149703678 creator A5058296985 @default.
- W2149703678 creator A5069909118 @default.
- W2149703678 creator A5086250528 @default.
- W2149703678 date "2000-01-01" @default.
- W2149703678 modified "2023-09-27" @default.
- W2149703678 title "Middle ear effusion IL-6 concentration in bacterial and non-bacterial acute otitis media" @default.
- W2149703678 cites W1594588076 @default.
- W2149703678 cites W2006819223 @default.
- W2149703678 cites W2014251299 @default.
- W2149703678 cites W2025714061 @default.
- W2149703678 cites W2052023212 @default.
- W2149703678 cites W2054946013 @default.
- W2149703678 cites W2117816562 @default.
- W2149703678 cites W2132097733 @default.
- W2149703678 cites W2148734519 @default.
- W2149703678 cites W21498212 @default.
- W2149703678 cites W2164321798 @default.
- W2149703678 cites W92982204 @default.
- W2149703678 doi "https://doi.org/10.1080/713794564" @default.
- W2149703678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11071086" @default.
- W2149703678 hasPublicationYear "2000" @default.
- W2149703678 type Work @default.
- W2149703678 sameAs 2149703678 @default.
- W2149703678 citedByCount "3" @default.
- W2149703678 countsByYear W21497036782015 @default.
- W2149703678 crossrefType "journal-article" @default.
- W2149703678 hasAuthorship W2149703678A5050824632 @default.
- W2149703678 hasAuthorship W2149703678A5058296985 @default.
- W2149703678 hasAuthorship W2149703678A5069909118 @default.
- W2149703678 hasAuthorship W2149703678A5086250528 @default.
- W2149703678 hasConcept C126322002 @default.
- W2149703678 hasConcept C137627325 @default.
- W2149703678 hasConcept C141071460 @default.
- W2149703678 hasConcept C163430725 @default.
- W2149703678 hasConcept C203014093 @default.
- W2149703678 hasConcept C2776439223 @default.
- W2149703678 hasConcept C2777846895 @default.
- W2149703678 hasConcept C2780942790 @default.
- W2149703678 hasConcept C2908979688 @default.
- W2149703678 hasConcept C501593827 @default.
- W2149703678 hasConcept C71924100 @default.
- W2149703678 hasConcept C86803240 @default.
- W2149703678 hasConcept C89423630 @default.
- W2149703678 hasConcept C90924648 @default.
- W2149703678 hasConceptScore W2149703678C126322002 @default.
- W2149703678 hasConceptScore W2149703678C137627325 @default.
- W2149703678 hasConceptScore W2149703678C141071460 @default.
- W2149703678 hasConceptScore W2149703678C163430725 @default.
- W2149703678 hasConceptScore W2149703678C203014093 @default.
- W2149703678 hasConceptScore W2149703678C2776439223 @default.
- W2149703678 hasConceptScore W2149703678C2777846895 @default.
- W2149703678 hasConceptScore W2149703678C2780942790 @default.
- W2149703678 hasConceptScore W2149703678C2908979688 @default.
- W2149703678 hasConceptScore W2149703678C501593827 @default.
- W2149703678 hasConceptScore W2149703678C71924100 @default.
- W2149703678 hasConceptScore W2149703678C86803240 @default.
- W2149703678 hasConceptScore W2149703678C89423630 @default.
- W2149703678 hasConceptScore W2149703678C90924648 @default.
- W2149703678 hasIssue "9" @default.
- W2149703678 hasLocation W21497036781 @default.
- W2149703678 hasLocation W21497036782 @default.
- W2149703678 hasOpenAccess W2149703678 @default.
- W2149703678 hasPrimaryLocation W21497036781 @default.
- W2149703678 hasRelatedWork W1998636800 @default.
- W2149703678 hasRelatedWork W2013452417 @default.
- W2149703678 hasRelatedWork W2021784539 @default.
- W2149703678 hasRelatedWork W2033918504 @default.
- W2149703678 hasRelatedWork W2068053614 @default.
- W2149703678 hasRelatedWork W2082434961 @default.
- W2149703678 hasRelatedWork W2090610754 @default.
- W2149703678 hasRelatedWork W2414858984 @default.
- W2149703678 hasRelatedWork W2609127402 @default.
- W2149703678 hasRelatedWork W4231246317 @default.
- W2149703678 hasVolume "89" @default.
- W2149703678 isParatext "false" @default.
- W2149703678 isRetracted "false" @default.
- W2149703678 magId "2149703678" @default.
- W2149703678 workType "article" @default.