Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149706597> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2149706597 endingPage "235" @default.
- W2149706597 startingPage "228" @default.
- W2149706597 abstract "Abstract Background and Objectives Previous in vitro studies have suggested that IGF‐1 stimulation can lead a more aggressive breast cancers and subsequent poor prognosis in breast cancer patients. We aim to how IGF‐1 and IGF‐1R mRNA levels in breast cancer are associated with disease‐free survival (DFS) and other clinicopathological factors. Methods IGF‐1 and IGF‐1R mRNA levels were measured in breast cancer tissue from 132 patients using real‐time PCR. DFS and clinicopathological information were obtained from patient case notes. Results IGF‐1 and IGF‐1R mRNA levels did not correlate with any clinicopathological factors. Patients who relapsed had lower IGF‐1 mRNA levels in their tumour tissue compared to those who remained disease‐free during the 5‐year follow‐up period. Patients who had ER‐positive breast cancers with high IGF‐1 mRNA levels had longer DFS compared to those with low IGF‐1 mRNA levels. IGF‐1 mRNA levels was not associated with DFS in patients with ER‐negative cancers. IGF‐1R mRNA levels was not associated with DFS in any subgroup analysis. Multivariate analysis showed that IGF‐1 mRNA levels and histopathological grade were independent predictors of DFS. Conclusions Breast cancer tissue IGF‐1 expression is a favourable prognostic indicator and could be used in clinical setting in planning for adjuvant treatment. J. Surg. Oncol. 2011; 104:228–235. © 2011 Wiley‐Liss, Inc." @default.
- W2149706597 created "2016-06-24" @default.
- W2149706597 creator A5006935581 @default.
- W2149706597 creator A5032508165 @default.
- W2149706597 creator A5034642004 @default.
- W2149706597 creator A5086474455 @default.
- W2149706597 date "2011-04-07" @default.
- W2149706597 modified "2023-10-16" @default.
- W2149706597 title "The prognostic significance of the insulin-like growth factor-1 ligand and receptor expression in breast cancer tissue" @default.
- W2149706597 cites W1990275850 @default.
- W2149706597 cites W1998961381 @default.
- W2149706597 cites W1999496029 @default.
- W2149706597 cites W2007278291 @default.
- W2149706597 cites W2007571389 @default.
- W2149706597 cites W2010093230 @default.
- W2149706597 cites W2027166284 @default.
- W2149706597 cites W2027195200 @default.
- W2149706597 cites W2030083110 @default.
- W2149706597 cites W2033079375 @default.
- W2149706597 cites W2034978998 @default.
- W2149706597 cites W2063361476 @default.
- W2149706597 cites W2071040328 @default.
- W2149706597 cites W2079113033 @default.
- W2149706597 cites W2079263525 @default.
- W2149706597 cites W2079894826 @default.
- W2149706597 cites W2080886948 @default.
- W2149706597 cites W2118826846 @default.
- W2149706597 cites W2123129045 @default.
- W2149706597 cites W2165664908 @default.
- W2149706597 cites W2322168524 @default.
- W2149706597 doi "https://doi.org/10.1002/jso.21916" @default.
- W2149706597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21480260" @default.
- W2149706597 hasPublicationYear "2011" @default.
- W2149706597 type Work @default.
- W2149706597 sameAs 2149706597 @default.
- W2149706597 citedByCount "7" @default.
- W2149706597 countsByYear W21497065972014 @default.
- W2149706597 countsByYear W21497065972015 @default.
- W2149706597 countsByYear W21497065972020 @default.
- W2149706597 countsByYear W21497065972021 @default.
- W2149706597 crossrefType "journal-article" @default.
- W2149706597 hasAuthorship W2149706597A5006935581 @default.
- W2149706597 hasAuthorship W2149706597A5032508165 @default.
- W2149706597 hasAuthorship W2149706597A5034642004 @default.
- W2149706597 hasAuthorship W2149706597A5086474455 @default.
- W2149706597 hasConcept C104317684 @default.
- W2149706597 hasConcept C105580179 @default.
- W2149706597 hasConcept C121608353 @default.
- W2149706597 hasConcept C126322002 @default.
- W2149706597 hasConcept C142724271 @default.
- W2149706597 hasConcept C143998085 @default.
- W2149706597 hasConcept C170493617 @default.
- W2149706597 hasConcept C2775960820 @default.
- W2149706597 hasConcept C2780689927 @default.
- W2149706597 hasConcept C530470458 @default.
- W2149706597 hasConcept C55493867 @default.
- W2149706597 hasConcept C71924100 @default.
- W2149706597 hasConcept C86803240 @default.
- W2149706597 hasConceptScore W2149706597C104317684 @default.
- W2149706597 hasConceptScore W2149706597C105580179 @default.
- W2149706597 hasConceptScore W2149706597C121608353 @default.
- W2149706597 hasConceptScore W2149706597C126322002 @default.
- W2149706597 hasConceptScore W2149706597C142724271 @default.
- W2149706597 hasConceptScore W2149706597C143998085 @default.
- W2149706597 hasConceptScore W2149706597C170493617 @default.
- W2149706597 hasConceptScore W2149706597C2775960820 @default.
- W2149706597 hasConceptScore W2149706597C2780689927 @default.
- W2149706597 hasConceptScore W2149706597C530470458 @default.
- W2149706597 hasConceptScore W2149706597C55493867 @default.
- W2149706597 hasConceptScore W2149706597C71924100 @default.
- W2149706597 hasConceptScore W2149706597C86803240 @default.
- W2149706597 hasIssue "3" @default.
- W2149706597 hasLocation W21497065971 @default.
- W2149706597 hasLocation W21497065972 @default.
- W2149706597 hasOpenAccess W2149706597 @default.
- W2149706597 hasPrimaryLocation W21497065971 @default.
- W2149706597 hasRelatedWork W2014231481 @default.
- W2149706597 hasRelatedWork W2058160713 @default.
- W2149706597 hasRelatedWork W2099817208 @default.
- W2149706597 hasRelatedWork W2119436088 @default.
- W2149706597 hasRelatedWork W2121592873 @default.
- W2149706597 hasRelatedWork W2130733926 @default.
- W2149706597 hasRelatedWork W2590769241 @default.
- W2149706597 hasRelatedWork W2800670286 @default.
- W2149706597 hasRelatedWork W2982823661 @default.
- W2149706597 hasRelatedWork W2189320406 @default.
- W2149706597 hasVolume "104" @default.
- W2149706597 isParatext "false" @default.
- W2149706597 isRetracted "false" @default.
- W2149706597 magId "2149706597" @default.
- W2149706597 workType "article" @default.