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• W2149715233 abstract "Children with the severe forms of osteogenesis imperfecta have in several studies been treated with intravenous pamidronate, but there are only few reports of the effect of early treatment.To evaluate the effect of treatment started in infancy.In a prospective observational study, with a historic control group, intravenous disodium pamidronate (APD) was given as monthly infusions to 11 children with osteogenesis imperfecta aged 3-13 (median 3.6) months, who had severe osteogenesis imperfecta with congenital bowing of the femora and vertebral compression fractures.During treatment of children aged between 3 and 6 (median 4.5) years, dual-energy x ray absorptiometry measurements of the lumbar spine showed a gradual increase in bone density. Bone metabolism parameters in serum (alkaline phosphatase, osteocalcin, procollagen 1 carboxy-terminal peptide, collagen 1 teleopeptide) and in urine (deoxypyridinoline) indicated a decrease in bone turnover. An improvement of mobility was seen and at the latest recording, at the age of 3.3-6.5 (median 4.8) years, the children could all walk. Vertebral remodelling was seen, with increased vertebral height, and no child developed scoliosis, kyphosis or basilar impression. All children required femoral intramedullar rods for fractures, and five needed tibial rodding for extreme curvatures that prevented functional standing and walking. No adverse effects were seen on growth, fracture healing or blood chemistry.APD is an efficient symptomatic treatment for infants with severe osteogenesis imperfecta, but additional orthopaedic surgery is often needed. Early treatment may prevent scoliosis and basilar impression. Long-term follow-up is important." @default.
• W2149715233 created "2016-06-24" @default.
• W2149715233 creator A5038097343 @default.
• W2149715233 creator A5062398478 @default.
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• W2149715233 date "2006-11-17" @default.
• W2149715233 modified "2023-10-01" @default.
• W2149715233 title "Intravenous pamidronate treatment of infants with severe osteogenesis imperfecta" @default.
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• W2149715233 doi "https://doi.org/10.1136/adc.2006.096552" @default.
• W2149715233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2083683" @default.
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