FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149718877> ?p ?o ?g. }

• W2149718877 endingPage "H240" @default.
• W2149718877 startingPage "H234" @default.
• W2149718877 abstract "Cardiac interstitial fibrillar collagen accumulation, such as that associated with chronic pressure overload (PO), has been shown to impair left ventricular diastolic function. Therefore, insight into cellular mechanisms that mediate excessive collagen deposition in the myocardium is pivotal to this important area of research. Collagen is secreted as a soluble procollagen molecule with NH 2 - and COOH (C)-terminal propeptides. Cleavage of these propeptides is required for collagen incorporation to insoluble collagen fibrils. The C-procollagen proteinase, bone morphogenic protein 1, cleaves the C-propeptide of procollagen. Procollagen C-endopeptidase enhancer (PCOLCE) 2, an enhancer of bone morphogenic protein-1 activity in vitro, is expressed at high levels in the myocardium. However, whether the absence of PCOLCE2 affects collagen content at baseline or after PO induced by transverse aortic constriction (TAC) has never been examined. Accordingly, in vivo procollagen processing and deposition were examined in wild-type (WT) and PCOLCE2-null mice. No significant differences in collagen content or myocardial stiffness were detected in non-TAC (control) PCOLCE2-null versus WT mice. After TAC-induced PO, PCOLCE2-null hearts demonstrated a lesser collagen content (PCOLCE2-null TAC collagen volume fraction, 0.41% ± 0.07 vs. WT TAC, 1.2% ± 0.3) and lower muscle stiffness compared with WT PO hearts [PCOLCE2-null myocardial stiffness (β), 0.041 ± 0.002 vs. WT myocardial stiffness, 0.065 ± 0.001]. In addition, in vitro, PCOLCE2-null cardiac fibroblasts exhibited reductions in efficiency of C-propeptide cleavage, as demonstrated by increases in procollagen α1(I) and decreased levels of processed collagen α1(I) versus WT cardiac fibroblasts. Hence, PCOLCE2 is required for efficient procollagen processing and deposition of fibrillar collagen in the PO myocardium. These results support a critical role for procollagen processing in the regulation of collagen deposition in the heart." @default.
• W2149718877 created "2016-06-24" @default.
• W2149718877 creator A5014049392 @default.
• W2149718877 creator A5035505682 @default.
• W2149718877 creator A5038364145 @default.
• W2149718877 creator A5047300992 @default.
• W2149718877 creator A5047833899 @default.
• W2149718877 creator A5053390482 @default.
• W2149718877 date "2012-07-15" @default.
• W2149718877 modified "2023-09-28" @default.
• W2149718877 title "Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload" @default.
• W2149718877 cites W1502422762 @default.
• W2149718877 cites W1974515438 @default.
• W2149718877 cites W1992203325 @default.
• W2149718877 cites W2034462747 @default.
• W2149718877 cites W2036027495 @default.
• W2149718877 cites W2041966195 @default.
• W2149718877 cites W2057490727 @default.
• W2149718877 cites W2061613731 @default.
• W2149718877 cites W2061963189 @default.
• W2149718877 cites W2072158996 @default.
• W2149718877 cites W2075282559 @default.
• W2149718877 cites W2081172215 @default.
• W2149718877 cites W2097707959 @default.
• W2149718877 cites W2098296263 @default.
• W2149718877 cites W2105115122 @default.
• W2149718877 cites W2106513436 @default.
• W2149718877 cites W2109257291 @default.
• W2149718877 cites W2109281287 @default.
• W2149718877 cites W2111972252 @default.
• W2149718877 cites W2113463710 @default.
• W2149718877 cites W2124492445 @default.
• W2149718877 cites W2124694949 @default.
• W2149718877 cites W2133917860 @default.
• W2149718877 cites W2158118095 @default.
• W2149718877 cites W2161340566 @default.
• W2149718877 cites W2168417210 @default.
• W2149718877 cites W2171417787 @default.
• W2149718877 doi "https://doi.org/10.1152/ajpheart.00227.2012" @default.
• W2149718877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3404697" @default.
• W2149718877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22610170" @default.
• W2149718877 hasPublicationYear "2012" @default.
• W2149718877 type Work @default.
• W2149718877 sameAs 2149718877 @default.
• W2149718877 citedByCount "44" @default.
• W2149718877 countsByYear W21497188772013 @default.
• W2149718877 countsByYear W21497188772014 @default.
• W2149718877 countsByYear W21497188772015 @default.
• W2149718877 countsByYear W21497188772016 @default.
• W2149718877 countsByYear W21497188772017 @default.
• W2149718877 countsByYear W21497188772018 @default.
• W2149718877 countsByYear W21497188772019 @default.
• W2149718877 countsByYear W21497188772020 @default.
• W2149718877 countsByYear W21497188772021 @default.
• W2149718877 countsByYear W21497188772022 @default.
• W2149718877 countsByYear W21497188772023 @default.
• W2149718877 crossrefType "journal-article" @default.
• W2149718877 hasAuthorship W2149718877A5014049392 @default.
• W2149718877 hasAuthorship W2149718877A5035505682 @default.
• W2149718877 hasAuthorship W2149718877A5038364145 @default.
• W2149718877 hasAuthorship W2149718877A5047300992 @default.
• W2149718877 hasAuthorship W2149718877A5047833899 @default.
• W2149718877 hasAuthorship W2149718877A5053390482 @default.
• W2149718877 hasBestOaLocation W21497188772 @default.
• W2149718877 hasConcept C104317684 @default.
• W2149718877 hasConcept C104826730 @default.
• W2149718877 hasConcept C111936080 @default.
• W2149718877 hasConcept C126322002 @default.
• W2149718877 hasConcept C134018914 @default.
• W2149718877 hasConcept C150194340 @default.
• W2149718877 hasConcept C181199279 @default.
• W2149718877 hasConcept C185592680 @default.
• W2149718877 hasConcept C189165786 @default.
• W2149718877 hasConcept C2778198053 @default.
• W2149718877 hasConcept C2778271984 @default.
• W2149718877 hasConcept C2779797417 @default.
• W2149718877 hasConcept C2780644872 @default.
• W2149718877 hasConcept C3018791406 @default.
• W2149718877 hasConcept C38008103 @default.
• W2149718877 hasConcept C55493867 @default.
• W2149718877 hasConcept C64348721 @default.
• W2149718877 hasConcept C71924100 @default.
• W2149718877 hasConcept C7860815 @default.
• W2149718877 hasConcept C86803240 @default.
• W2149718877 hasConceptScore W2149718877C104317684 @default.
• W2149718877 hasConceptScore W2149718877C104826730 @default.
• W2149718877 hasConceptScore W2149718877C111936080 @default.
• W2149718877 hasConceptScore W2149718877C126322002 @default.
• W2149718877 hasConceptScore W2149718877C134018914 @default.
• W2149718877 hasConceptScore W2149718877C150194340 @default.
• W2149718877 hasConceptScore W2149718877C181199279 @default.
• W2149718877 hasConceptScore W2149718877C185592680 @default.
• W2149718877 hasConceptScore W2149718877C189165786 @default.
• W2149718877 hasConceptScore W2149718877C2778198053 @default.
• W2149718877 hasConceptScore W2149718877C2778271984 @default.
• W2149718877 hasConceptScore W2149718877C2779797417 @default.
• W2149718877 hasConceptScore W2149718877C2780644872 @default.
• W2149718877 hasConceptScore W2149718877C3018791406 @default.

• next