FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149721630> ?p ?o ?g. }

• W2149721630 endingPage "322" @default.
• W2149721630 startingPage "313" @default.
• W2149721630 abstract "Context: Colchicine (CLC) causes cell death by destabilizing the tubulin unit. However, it ionizes at physiological pH resultant low bioavailability and therapeutic efficacy.Objectives: We have attempted to augment the bioavailability of CLC by fabricating the inclusion complex with hydroxypropyl-β-cyclodextrin (HP-β-CD).Materials and methods: CLC-HP-β-CD inclusion complex was prepared and evaluated with Fourier-transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, scanning electron microscopy, 1H nuclear magnetic resonance (1H NMR) spectroscopy and rotating frame overhauser enhancement spectroscopy (ROESY). Oral bioavailability of CLC-HP-β-CD inclusion complex was analyzed using high performance liquid chromatography method.Results and discussion: Our phase-solubility data indicated the formation of a stable complex with Kc ~0.31 mM−1 at pH 7.4. 1H NMR ascertains that NHCOCH3 moiety of CLC enters in the HP-β-CD cavity and deshielded the H-3 and H-5 protons. ROESY also correlates the Hf and Hg of CLC with H-3 and H-5 protons of HP-β-CD and indicates that Hf and Hg protons of CLC are present either as cis and/or trans form in CLC-HP-β-CD inclusion complex. Pharmacokinetic studies showed a 1.82-fold increase in absolute bioavailability of CLC upon complexation.Conclusion: CLC-HP-β-CD inclusion complex may potentially be used as a viable formulation of CLC." @default.
• W2149721630 created "2016-06-24" @default.
• W2149721630 creator A5003423341 @default.
• W2149721630 creator A5005673101 @default.
• W2149721630 creator A5035479926 @default.
• W2149721630 creator A5067433723 @default.
• W2149721630 creator A5069186266 @default.
• W2149721630 creator A5076147458 @default.
• W2149721630 date "2011-06-23" @default.
• W2149721630 modified "2023-09-23" @default.
• W2149721630 title "Inclusion complex of colchicine in hydroxypropyl-β-cyclodextrin tenders better solubility and improved pharmacokinetics" @default.
• W2149721630 cites W1559338548 @default.
• W2149721630 cites W1970708374 @default.
• W2149721630 cites W1985478944 @default.
• W2149721630 cites W2002015209 @default.
• W2149721630 cites W2013001731 @default.
• W2149721630 cites W2019059658 @default.
• W2149721630 cites W2024827120 @default.
• W2149721630 cites W2026006408 @default.
• W2149721630 cites W2046017608 @default.
• W2149721630 cites W2074582913 @default.
• W2149721630 cites W2086618179 @default.
• W2149721630 cites W2136850058 @default.
• W2149721630 doi "https://doi.org/10.3109/10837450.2011.591801" @default.
• W2149721630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21699389" @default.
• W2149721630 hasPublicationYear "2011" @default.
• W2149721630 type Work @default.
• W2149721630 sameAs 2149721630 @default.
• W2149721630 citedByCount "20" @default.
• W2149721630 countsByYear W21497216302012 @default.
• W2149721630 countsByYear W21497216302013 @default.
• W2149721630 countsByYear W21497216302014 @default.
• W2149721630 countsByYear W21497216302016 @default.
• W2149721630 countsByYear W21497216302017 @default.
• W2149721630 countsByYear W21497216302018 @default.
• W2149721630 countsByYear W21497216302019 @default.
• W2149721630 countsByYear W21497216302020 @default.
• W2149721630 countsByYear W21497216302021 @default.
• W2149721630 countsByYear W21497216302023 @default.
• W2149721630 crossrefType "journal-article" @default.
• W2149721630 hasAuthorship W2149721630A5003423341 @default.
• W2149721630 hasAuthorship W2149721630A5005673101 @default.
• W2149721630 hasAuthorship W2149721630A5035479926 @default.
• W2149721630 hasAuthorship W2149721630A5067433723 @default.
• W2149721630 hasAuthorship W2149721630A5069186266 @default.
• W2149721630 hasAuthorship W2149721630A5076147458 @default.
• W2149721630 hasConcept C103319777 @default.
• W2149721630 hasConcept C127413603 @default.
• W2149721630 hasConcept C13965031 @default.
• W2149721630 hasConcept C151730666 @default.
• W2149721630 hasConcept C155574463 @default.
• W2149721630 hasConcept C160892712 @default.
• W2149721630 hasConcept C178790620 @default.
• W2149721630 hasConcept C181389837 @default.
• W2149721630 hasConcept C184651966 @default.
• W2149721630 hasConcept C185592680 @default.
• W2149721630 hasConcept C2776568683 @default.
• W2149721630 hasConcept C2778649806 @default.
• W2149721630 hasConcept C2779343474 @default.
• W2149721630 hasConcept C2779433975 @default.
• W2149721630 hasConcept C42360764 @default.
• W2149721630 hasConcept C43617362 @default.
• W2149721630 hasConcept C66974803 @default.
• W2149721630 hasConcept C71240020 @default.
• W2149721630 hasConcept C71924100 @default.
• W2149721630 hasConcept C86803240 @default.
• W2149721630 hasConcept C98274493 @default.
• W2149721630 hasConceptScore W2149721630C103319777 @default.
• W2149721630 hasConceptScore W2149721630C127413603 @default.
• W2149721630 hasConceptScore W2149721630C13965031 @default.
• W2149721630 hasConceptScore W2149721630C151730666 @default.
• W2149721630 hasConceptScore W2149721630C155574463 @default.
• W2149721630 hasConceptScore W2149721630C160892712 @default.
• W2149721630 hasConceptScore W2149721630C178790620 @default.
• W2149721630 hasConceptScore W2149721630C181389837 @default.
• W2149721630 hasConceptScore W2149721630C184651966 @default.
• W2149721630 hasConceptScore W2149721630C185592680 @default.
• W2149721630 hasConceptScore W2149721630C2776568683 @default.
• W2149721630 hasConceptScore W2149721630C2778649806 @default.
• W2149721630 hasConceptScore W2149721630C2779343474 @default.
• W2149721630 hasConceptScore W2149721630C2779433975 @default.
• W2149721630 hasConceptScore W2149721630C42360764 @default.
• W2149721630 hasConceptScore W2149721630C43617362 @default.
• W2149721630 hasConceptScore W2149721630C66974803 @default.
• W2149721630 hasConceptScore W2149721630C71240020 @default.
• W2149721630 hasConceptScore W2149721630C71924100 @default.
• W2149721630 hasConceptScore W2149721630C86803240 @default.
• W2149721630 hasConceptScore W2149721630C98274493 @default.
• W2149721630 hasIssue "2" @default.
• W2149721630 hasLocation W21497216301 @default.
• W2149721630 hasLocation W21497216302 @default.
• W2149721630 hasOpenAccess W2149721630 @default.
• W2149721630 hasPrimaryLocation W21497216301 @default.
• W2149721630 hasRelatedWork W1970219835 @default.
• W2149721630 hasRelatedWork W1980198218 @default.
• W2149721630 hasRelatedWork W2001313397 @default.
• W2149721630 hasRelatedWork W2032475795 @default.
• W2149721630 hasRelatedWork W2053890001 @default.

• next