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• W2149737058 endingPage "1956" @default.
• W2149737058 startingPage "1949" @default.
• W2149737058 abstract "ABSTRACT More effective vaccines against Mycobacterium tuberculosis may contribute to the control of this major human pathogen. DNA vaccines encoding single mycobacterial proteins stimulate antimycobacterial T-cell responses and induce partial protection against M. tuberculosis in animal models. The protective efficacy of these vaccines encoding a single antigen, however, has been less than that afforded by the current vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG). The heterodimeric cytokine interleukin-12 (IL-12) potentiates the induction and maintenance of the type 1 helper T-cell response. We have developed a novel self-splicing vector based on the 2A protein of foot-and-mouth disease virus that permits the coordinate expression of both chains of IL-12 (p2AIL12). Coimmunization with this vector and DNA expressing M. tuberculosis antigen 85B or MPT64 enhanced the specific lymphocyte proliferative response and increased the frequency of specific gamma interferon-secreting T cells against the whole protein and a defined CD8 + T-cell epitope on MPT64. Further, coimmunizing with p2AIL12 significantly increased the protective efficacy of DNA-85 in the lung against an aerosol challenge with M. tuberculosis to the level achieved with BCG. Therefore, codelivery of an IL-12-secreting plasmid may be a potent strategy for enhancing the protective efficacy of vaccines against M. tuberculosis." @default.
• W2149737058 created "2016-06-24" @default.
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• W2149737058 date "2002-04-01" @default.
• W2149737058 modified "2023-09-30" @default.
• W2149737058 title "Coexpression of Interleukin-12 Chains by a Self-Splicing Vector Increases the Protective Cellular Immune Response of DNA and<i>Mycobacterium bovis</i>BCG Vaccines against<i>Mycobacterium tuberculosis</i>" @default.
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• W2149737058 doi "https://doi.org/10.1128/iai.70.4.1949-1956.2002" @default.
• W2149737058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/127841" @default.
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