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• W2149738995 abstract "The bacterium Deinococcus radiodurans survives ionizing irradiation and other DNA-damaging assaults at doses that are lethal to all other organisms. How D. radiodurans accurately reconstructs its genome from hundreds of radiation-generated fragments in the absence of an intact template is unknown. Here we show that the D. radiodurans genome assumes an unusual toroidal morphology that may contribute to its radioresistance. We propose that, because of restricted diffusion within the tightly packed and laterally ordered DNA toroids, radiation-generated free DNA ends are held together, which may facilitate template-independent yet error-free joining of DNA breaks." @default.
• W2149738995 created "2016-06-24" @default.
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• W2149738995 date "2003-01-10" @default.
• W2149738995 modified "2023-10-14" @default.
• W2149738995 title "Ringlike Structure of the <i>Deinococcus radiodurans</i> Genome: A Key to Radioresistance?" @default.
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• W2149738995 doi "https://doi.org/10.1126/science.1077865" @default.
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