FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149741097> ?p ?o ?g. }

• W2149741097 endingPage "3061" @default.
• W2149741097 startingPage "3046" @default.
• W2149741097 abstract "The solventogenic bacterium Clostridium acetobutylicum is an important species of the Clostridium community. To develop a fundamental tool that is useful for biological studies of C. acetobutylicum, we established a high resolution proteome reference map for this species. We identified 1206 spots representing 564 different proteins by mass spectrometry, covering approximately 50% of major metabolic pathways. To better understand the relationship between butanol tolerance and butanol yield, we performed a comparative proteomic analysis between the wild type strain DSM 1731 and the mutant Rh8, which has higher butanol tolerance and higher butanol yield. Comparative proteomic analysis of two strains at acidogenic and solventogenic phases revealed 102 differentially expressed proteins that are mainly involved in protein folding, solvent formation, amino acid metabolism, protein synthesis, nucleotide metabolism, transport, and others. Hierarchical clustering analysis revealed that over 70% of the 102 differentially expressed proteins in mutant Rh8 were either upregulated (e.g., chaperones and solvent formation related) or downregulated (e.g., amino acid metabolism and protein synthesis related) in both acidogenic and solventogenic phase, which, respectively, are only upregulated or downregulated in solventogenic phase in the wild type strain. This suggests that Rh8 cells have evolved a mechanism to prepare themselves for butanol challenge before butanol is produced, leading to an increased butanol yield. This is the first report on the comparative proteome analysis of a mutant strain and a base strain of C. acetobutylicum. The fundamental proteomic data and analyses will be useful for further elucidating the biological mechanism of butanol tolerance and/or enhanced butanol production." @default.
• W2149741097 created "2016-06-24" @default.
• W2149741097 creator A5009187032 @default.
• W2149741097 creator A5024195111 @default.
• W2149741097 creator A5033348256 @default.
• W2149741097 creator A5041077139 @default.
• W2149741097 creator A5070373092 @default.
• W2149741097 creator A5083532124 @default.
• W2149741097 creator A5084845056 @default.
• W2149741097 creator A5085591303 @default.
• W2149741097 creator A5088160033 @default.
• W2149741097 creator A5038316557 @default.
• W2149741097 date "2010-05-17" @default.
• W2149741097 modified "2023-09-25" @default.
• W2149741097 title "Proteome Reference Map and Comparative Proteomic Analysis between a Wild Type <i>Clostridium acetobutylicum</i> DSM 1731 and its Mutant with Enhanced Butanol Tolerance and Butanol Yield" @default.
• W2149741097 cites W1482749413 @default.
• W2149741097 cites W1488079130 @default.
• W2149741097 cites W1493095844 @default.
• W2149741097 cites W1506502502 @default.
• W2149741097 cites W1517927168 @default.
• W2149741097 cites W1588239034 @default.
• W2149741097 cites W1590181828 @default.
• W2149741097 cites W1603897681 @default.
• W2149741097 cites W1606423922 @default.
• W2149741097 cites W1816790847 @default.
• W2149741097 cites W1939556909 @default.
• W2149741097 cites W1957671946 @default.
• W2149741097 cites W1963906505 @default.
• W2149741097 cites W1970190032 @default.
• W2149741097 cites W1972520547 @default.
• W2149741097 cites W1972875046 @default.
• W2149741097 cites W1975304761 @default.
• W2149741097 cites W1975521395 @default.
• W2149741097 cites W1990453950 @default.
• W2149741097 cites W2000604837 @default.
• W2149741097 cites W2001763105 @default.
• W2149741097 cites W2002633990 @default.
• W2149741097 cites W2005038694 @default.
• W2149741097 cites W2008519191 @default.
• W2149741097 cites W2013371031 @default.
• W2149741097 cites W2019933034 @default.
• W2149741097 cites W2025679437 @default.
• W2149741097 cites W2032132762 @default.
• W2149741097 cites W2033585782 @default.
• W2149741097 cites W2037060512 @default.
• W2149741097 cites W2038884121 @default.
• W2149741097 cites W2040048905 @default.
• W2149741097 cites W2041306673 @default.
• W2149741097 cites W2065955310 @default.
• W2149741097 cites W2076599710 @default.
• W2149741097 cites W2086871265 @default.
• W2149741097 cites W2087561640 @default.
• W2149741097 cites W2088259194 @default.
• W2149741097 cites W2092937522 @default.
• W2149741097 cites W2101613294 @default.
• W2149741097 cites W2104639993 @default.
• W2149741097 cites W2105495791 @default.
• W2149741097 cites W2109625174 @default.
• W2149741097 cites W2112508554 @default.
• W2149741097 cites W2123051512 @default.
• W2149741097 cites W2125905611 @default.
• W2149741097 cites W2128702715 @default.
• W2149741097 cites W2133843115 @default.
• W2149741097 cites W2136343510 @default.
• W2149741097 cites W2137626431 @default.
• W2149741097 cites W2138231210 @default.
• W2149741097 cites W2140918059 @default.
• W2149741097 cites W2144025274 @default.
• W2149741097 cites W2146205446 @default.
• W2149741097 cites W2151603148 @default.
• W2149741097 cites W2156845325 @default.
• W2149741097 cites W2156896391 @default.
• W2149741097 cites W2159945949 @default.
• W2149741097 cites W2164528781 @default.
• W2149741097 cites W2165848622 @default.
• W2149741097 cites W2166144231 @default.
• W2149741097 cites W2168778058 @default.
• W2149741097 cites W4240027708 @default.
• W2149741097 cites W45534775 @default.
• W2149741097 doi "https://doi.org/10.1021/pr9012078" @default.
• W2149741097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20426490" @default.
• W2149741097 hasPublicationYear "2010" @default.
• W2149741097 type Work @default.
• W2149741097 sameAs 2149741097 @default.
• W2149741097 citedByCount "118" @default.
• W2149741097 countsByYear W21497410972012 @default.
• W2149741097 countsByYear W21497410972013 @default.
• W2149741097 countsByYear W21497410972014 @default.
• W2149741097 countsByYear W21497410972015 @default.
• W2149741097 countsByYear W21497410972016 @default.
• W2149741097 countsByYear W21497410972017 @default.
• W2149741097 countsByYear W21497410972018 @default.
• W2149741097 countsByYear W21497410972019 @default.
• W2149741097 countsByYear W21497410972020 @default.
• W2149741097 countsByYear W21497410972021 @default.
• W2149741097 countsByYear W21497410972022 @default.
• W2149741097 countsByYear W21497410972023 @default.
• W2149741097 crossrefType "journal-article" @default.

• next