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- W2149741917 abstract "The link between cholesterol and Alzheimer's disease has recently been revealed in Niemann–Pick type C disease. We found that NPC1−/− cells show decreased expression of APP at the cell surface and increased processing of APP through the β-secretase pathway resulting in increased C99, sAPPβ and intracellular Aβ40 levels. This effect is dependent on increased cholesterol levels, since cholesterol depletion reversed cell surface APP expression and lowered Aβ/C99 levels in NPC1−/− cells to the levels observed in wt cells. Finding that overexpression of C99, a direct γ-secretase substrate, does not lead to increased intracellular Aβ levels in NPC1−/− cells vs. CHOwt suggests that the effect on intracellular Aβ upon cholesterol accumulation in NPC1−/− cells is not due to increased APP cleavage by γ-secretase. Our results indicate that cholesterol may modulate APP processing indirectly by modulating APP expression at the cell surface and thus its cleavage by β-secretase." @default.
- W2149741917 created "2016-06-24" @default.
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- W2149741917 date "2010-07-01" @default.
- W2149741917 modified "2023-10-13" @default.
- W2149741917 title "Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway" @default.
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- W2149741917 doi "https://doi.org/10.1016/j.bbadis.2010.05.006" @default.
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