FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149742562> ?p ?o ?g. }

• W2149742562 endingPage "4060" @default.
• W2149742562 startingPage "4054" @default.
• W2149742562 abstract "Corticotropin-releasing factor (CRF) is the key regulator of the hypothalamic-pituitary-adrenal axis. CRF neurons cannot be distinguished morphologically from other neuroendocrine neurons in the paraventricular nucleus of the hypothalamus (PVH) without immunostaining. Thus, we generated a knock-in mouse that expresses modified yellow fluorescent protein (Venus) in CRF neurons (CRF-Venus), and yet its expression is driven by the CRF promoter and responds to changes in the interior milieu. In CRF-Venus, Venus-expressing neurons were distributed in brain regions harboring CRF neurons, including the PVH. The majority of Venus-expressing neurons overlapped with CRF-expressing neurons in the PVH, but many neurons expressed only Venus or CRF in a physiological glucocorticoid condition. After glucocorticoid deprivation, however, Venus expression intensified, and most Venus neurons coexpressed CRF. Conversely, Venus expression was suppressed by excess glucocorticoids. Expression of copeptin, a peptide encoded within the vasopressin gene, was induced in PVH-Venus neurons by glucocorticoid deprivation and suppressed by glucocorticoid administration. Thus, Venus neurons recapitulated glucocorticoid-dependent vasopressin expression in PVH-CRF neurons. Noradrenaline increased the frequency of glutamate-dependent excitatory postsynaptic currents recorded from Venus-expressing neurons in the voltage clamp mode. In addition, the CRF-iCre knock-in mouse was crossed with a CAG-CAT-EGFP reporter mouse to yield the TgCAG-CAT-EGFP/wt;CRFiCre/wt (EGFP/CRF-iCre) mouse, in which enhanced green fluorescent protein (EGFP) is driven by the CAG promoter. EGFP was expressed more constitutively in the PVH of EGFP/CRF-iCre mice. Thus, CRF-Venus may have an advantage for monitoring dynamic changes in CRF neurons and CRF networks in different glucocorticoid states." @default.
• W2149742562 created "2016-06-24" @default.
• W2149742562 creator A5053777415 @default.
• W2149742562 creator A5055805311 @default.
• W2149742562 creator A5058687274 @default.
• W2149742562 creator A5060353691 @default.
• W2149742562 creator A5061509682 @default.
• W2149742562 creator A5062883848 @default.
• W2149742562 creator A5075533925 @default.
• W2149742562 creator A5076017842 @default.
• W2149742562 creator A5076912400 @default.
• W2149742562 creator A5081271255 @default.
• W2149742562 creator A5086898337 @default.
• W2149742562 creator A5088291559 @default.
• W2149742562 date "2014-10-01" @default.
• W2149742562 modified "2023-10-13" @default.
• W2149742562 title "Visualization of Corticotropin-Releasing Factor Neurons by Fluorescent Proteins in the Mouse Brain and Characterization of Labeled Neurons in the Paraventricular Nucleus of the Hypothalamus" @default.
• W2149742562 cites W1509046486 @default.
• W2149742562 cites W1703083962 @default.
• W2149742562 cites W1944272128 @default.
• W2149742562 cites W1965337556 @default.
• W2149742562 cites W1971675083 @default.
• W2149742562 cites W1976770692 @default.
• W2149742562 cites W1979665827 @default.
• W2149742562 cites W1983632203 @default.
• W2149742562 cites W2005774467 @default.
• W2149742562 cites W2006593760 @default.
• W2149742562 cites W2008009288 @default.
• W2149742562 cites W2013177481 @default.
• W2149742562 cites W2014877416 @default.
• W2149742562 cites W2028135910 @default.
• W2149742562 cites W2041736210 @default.
• W2149742562 cites W2058989655 @default.
• W2149742562 cites W2061603512 @default.
• W2149742562 cites W2064055939 @default.
• W2149742562 cites W2066183427 @default.
• W2149742562 cites W2088357731 @default.
• W2149742562 cites W2095036452 @default.
• W2149742562 cites W2104135721 @default.
• W2149742562 cites W2112336919 @default.
• W2149742562 cites W2141011618 @default.
• W2149742562 cites W2143038141 @default.
• W2149742562 cites W2145691687 @default.
• W2149742562 cites W2154881521 @default.
• W2149742562 cites W2160273439 @default.
• W2149742562 cites W4253807475 @default.
• W2149742562 doi "https://doi.org/10.1210/en.2014-1182" @default.
• W2149742562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25057791" @default.
• W2149742562 hasPublicationYear "2014" @default.
• W2149742562 type Work @default.
• W2149742562 sameAs 2149742562 @default.
• W2149742562 citedByCount "33" @default.
• W2149742562 countsByYear W21497425622015 @default.
• W2149742562 countsByYear W21497425622016 @default.
• W2149742562 countsByYear W21497425622017 @default.
• W2149742562 countsByYear W21497425622018 @default.
• W2149742562 countsByYear W21497425622019 @default.
• W2149742562 countsByYear W21497425622020 @default.
• W2149742562 countsByYear W21497425622021 @default.
• W2149742562 countsByYear W21497425622022 @default.
• W2149742562 countsByYear W21497425622023 @default.
• W2149742562 crossrefType "journal-article" @default.
• W2149742562 hasAuthorship W2149742562A5053777415 @default.
• W2149742562 hasAuthorship W2149742562A5055805311 @default.
• W2149742562 hasAuthorship W2149742562A5058687274 @default.
• W2149742562 hasAuthorship W2149742562A5060353691 @default.
• W2149742562 hasAuthorship W2149742562A5061509682 @default.
• W2149742562 hasAuthorship W2149742562A5062883848 @default.
• W2149742562 hasAuthorship W2149742562A5075533925 @default.
• W2149742562 hasAuthorship W2149742562A5076017842 @default.
• W2149742562 hasAuthorship W2149742562A5076912400 @default.
• W2149742562 hasAuthorship W2149742562A5081271255 @default.
• W2149742562 hasAuthorship W2149742562A5086898337 @default.
• W2149742562 hasAuthorship W2149742562A5088291559 @default.
• W2149742562 hasBestOaLocation W21497425621 @default.
• W2149742562 hasConcept C126322002 @default.
• W2149742562 hasConcept C134018914 @default.
• W2149742562 hasConcept C169760540 @default.
• W2149742562 hasConcept C2777003273 @default.
• W2149742562 hasConcept C2778458438 @default.
• W2149742562 hasConcept C2778794669 @default.
• W2149742562 hasConcept C2780841215 @default.
• W2149742562 hasConcept C71924100 @default.
• W2149742562 hasConcept C86803240 @default.
• W2149742562 hasConceptScore W2149742562C126322002 @default.
• W2149742562 hasConceptScore W2149742562C134018914 @default.
• W2149742562 hasConceptScore W2149742562C169760540 @default.
• W2149742562 hasConceptScore W2149742562C2777003273 @default.
• W2149742562 hasConceptScore W2149742562C2778458438 @default.
• W2149742562 hasConceptScore W2149742562C2778794669 @default.
• W2149742562 hasConceptScore W2149742562C2780841215 @default.
• W2149742562 hasConceptScore W2149742562C71924100 @default.
• W2149742562 hasConceptScore W2149742562C86803240 @default.
• W2149742562 hasIssue "10" @default.
• W2149742562 hasLocation W21497425621 @default.
• W2149742562 hasLocation W21497425622 @default.
• W2149742562 hasOpenAccess W2149742562 @default.
• W2149742562 hasPrimaryLocation W21497425621 @default.

• next