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- W2149751073 abstract "Administration of mesenchymal stromal cells (MSC) improves functional outcome in the SOD1G93A mouse model of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) as well as in models of other neurological disorders. We have now investigated the effect of the interaction between MSC and motor neurons (derived from both non-transgenic and mutant SOD1G93A transgenic mice), NSC-34 cells and glial cells (astrocytes, microglia) (derived again from both non-transgenic and mutant SOD1G93A ALS transgenic mice) in vitro. In primary motor neurons, NSC-34 cells and astrocytes, MSC conditioned medium (MSC CM) attenuated staurosporine (STS) - induced apoptosis in a concentration-dependent manner. Studying MSC CM-induced expression of neurotrophic factors in astrocytes and NSC-34 cells, we found that glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) gene expression in astrocytes were significantly enhanced by MSC CM, with differential responses of non-transgenic and mutant astrocytes. Expression of Vascular Endothelial Growth Factor (VEGF) in NSC-34 cells was significantly upregulated upon MSC CM-treatment. MSC CM significantly reduced the expression of the cytokines TNFα and IL-6 and iNOS both in transgenic and non-transgenic astrocytes. Gene expression of the neuroprotective chemokine Fractalkine (CX3CL1) was also upregulated in mutant SOD1G93A transgenic astrocytes by MSC CM treatment. Correspondingly, MSC CM increased the respective receptor, CX3CR1, in mutant SOD1G93A transgenic microglia. Our data demonstrate that MSC modulate motor neuronal and glial response to apoptosis and inflammation. MSC therefore represent an interesting candidate for further preclinical and clinical evaluation in ALS." @default.
- W2149751073 created "2016-06-24" @default.
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- W2149751073 date "2013-09-12" @default.
- W2149751073 modified "2023-09-28" @default.
- W2149751073 title "Therapeutic Potential of Mesenchymal Stromal Cells and MSC Conditioned Medium in Amyotrophic Lateral Sclerosis (ALS) - In Vitro Evidence from Primary Motor Neuron Cultures, NSC-34 Cells, Astrocytes and Microglia" @default.
- W2149751073 cites W1493853215 @default.
- W2149751073 cites W1502647583 @default.
- W2149751073 cites W1533817008 @default.
- W2149751073 cites W1544759945 @default.
- W2149751073 cites W1546774597 @default.
- W2149751073 cites W1967824323 @default.
- W2149751073 cites W1968555166 @default.
- W2149751073 cites W1969593599 @default.
- W2149751073 cites W1974760547 @default.
- W2149751073 cites W1978370369 @default.
- W2149751073 cites W1987213146 @default.
- W2149751073 cites W1989633016 @default.
- W2149751073 cites W1990140740 @default.
- W2149751073 cites W1993326869 @default.
- W2149751073 cites W1994904606 @default.
- W2149751073 cites W2000266670 @default.
- W2149751073 cites W2005848913 @default.
- W2149751073 cites W2010233410 @default.
- W2149751073 cites W2014495235 @default.
- W2149751073 cites W2017887810 @default.
- W2149751073 cites W2018287616 @default.
- W2149751073 cites W2023644633 @default.
- W2149751073 cites W2029085167 @default.
- W2149751073 cites W2029887364 @default.
- W2149751073 cites W2032983732 @default.
- W2149751073 cites W2037174641 @default.
- W2149751073 cites W2038496797 @default.
- W2149751073 cites W2044415046 @default.
- W2149751073 cites W2047532953 @default.
- W2149751073 cites W2050279035 @default.
- W2149751073 cites W2053022788 @default.
- W2149751073 cites W2053184316 @default.
- W2149751073 cites W2053272214 @default.
- W2149751073 cites W2054876142 @default.
- W2149751073 cites W2066259320 @default.
- W2149751073 cites W2066543360 @default.
- W2149751073 cites W2066794469 @default.
- W2149751073 cites W2069351132 @default.
- W2149751073 cites W2070542281 @default.
- W2149751073 cites W2070720564 @default.
- W2149751073 cites W2071898079 @default.
- W2149751073 cites W2074908991 @default.
- W2149751073 cites W2079557467 @default.
- W2149751073 cites W2083959138 @default.
- W2149751073 cites W2084349415 @default.
- W2149751073 cites W2089592211 @default.
- W2149751073 cites W2092631923 @default.
- W2149751073 cites W2094100748 @default.
- W2149751073 cites W2099450715 @default.
- W2149751073 cites W2101741807 @default.
- W2149751073 cites W2103299339 @default.
- W2149751073 cites W2107660300 @default.
- W2149751073 cites W2107768418 @default.
- W2149751073 cites W2108678943 @default.
- W2149751073 cites W2113107925 @default.
- W2149751073 cites W2115855931 @default.
- W2149751073 cites W2120321527 @default.
- W2149751073 cites W2122265985 @default.
- W2149751073 cites W2128492849 @default.
- W2149751073 cites W2135522980 @default.
- W2149751073 cites W2136687695 @default.
- W2149751073 cites W2140294607 @default.
- W2149751073 cites W2142594288 @default.
- W2149751073 cites W2144414931 @default.
- W2149751073 cites W2145041062 @default.
- W2149751073 cites W2146546145 @default.
- W2149751073 cites W2148721608 @default.
- W2149751073 cites W2156969855 @default.
- W2149751073 cites W2157811993 @default.
- W2149751073 doi "https://doi.org/10.1371/journal.pone.0072926" @default.
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- W2149751073 hasPublicationYear "2013" @default.
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