FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149755517> ?p ?o ?g. }

• W2149755517 endingPage "1838" @default.
• W2149755517 startingPage "1824" @default.
• W2149755517 abstract "Background: We have developed an animal model of alcohol self‐administration that initially employs schedule‐induced polydipsia (SIP) to establish reliable ethanol consumption under open access (22 h/d) conditions with food and water concurrently available. SIP is an adjunctive behavior that is generated by constraining access to an important commodity (e.g., flavored food). The induction schedule and ethanol polydipsia generated under these conditions affords the opportunity to investigate the development of drinking typologies that lead to chronic, excessive alcohol consumption. Methods: Adult male cynomolgus monkeys (Macaca fascicularis) were induced to drink water and 4% (w/v in water) ethanol by a Fixed‐Time 300 seconds (FT‐300 seconds) schedule of banana‐flavored pellet delivery. The FT‐300 seconds schedule was in effect for 120 consecutive sessions, with daily induction doses increasing from 0.0 to 0.5 g/kg to 1.0 g/kg to 1.5 g/kg every 30 days. Following induction, the monkeys were allowed concurrent access to 4% (w/v) ethanol and water for 22 h/day for 12 months. Results: Drinking typographies during the induction of drinking 1.5 g/kg ethanol emerged that were highly predictive of the daily ethanol intake over the next 12 months. Specifically, the frequency in which monkeys ingested 1.5 g/kg ethanol without a 5‐minute lapse in drinking (defined as a bout of drinking) during induction strongly predicted (correlation 0.91) subsequent ethanol intake over the next 12 months of open access to ethanol. Blood ethanol during induction were highly correlated with intake and with drinking typography and ranged from 100 to 160 mg% when the monkeys drank their 1.5 g/kg dose in a single bout. Forty percent of the population became heavy drinkers (mean daily intakes >3.0 g/kg for 12 months) characterized by frequent “spree” drinking (intakes >4.0 g/kg/d). Conclusion: This model of ethanol self‐administration identifies early alcohol drinking typographies (gulping the equivalent of 6 drinks) that evolve into chronic heavy alcohol consumption in primates (drinking the equivalent of 16 to 20 drinks per day). The model may aid in identifying biological risks for establishing harmful alcohol drinking." @default.
• W2149755517 created "2016-06-24" @default.
• W2149755517 creator A5009474419 @default.
• W2149755517 creator A5020119710 @default.
• W2149755517 creator A5036959598 @default.
• W2149755517 creator A5047102441 @default.
• W2149755517 creator A5050008727 @default.
• W2149755517 creator A5086638451 @default.
• W2149755517 date "2008-09-17" @default.
• W2149755517 modified "2023-10-14" @default.
• W2149755517 title "Drinking Typography Established by Scheduled Induction Predicts Chronic Heavy Drinking in a Monkey Model of Ethanol Self-Administration" @default.
• W2149755517 cites W1217893529 @default.
• W2149755517 cites W1545677310 @default.
• W2149755517 cites W1978132959 @default.
• W2149755517 cites W1985969451 @default.
• W2149755517 cites W1999268557 @default.
• W2149755517 cites W2004144253 @default.
• W2149755517 cites W2011981060 @default.
• W2149755517 cites W2016075581 @default.
• W2149755517 cites W2018466510 @default.
• W2149755517 cites W2022106712 @default.
• W2149755517 cites W2024128220 @default.
• W2149755517 cites W2027893268 @default.
• W2149755517 cites W2030305913 @default.
• W2149755517 cites W2031397909 @default.
• W2149755517 cites W2032463054 @default.
• W2149755517 cites W2038191735 @default.
• W2149755517 cites W2038681951 @default.
• W2149755517 cites W2039786215 @default.
• W2149755517 cites W2057104160 @default.
• W2149755517 cites W2060547146 @default.
• W2149755517 cites W2068195019 @default.
• W2149755517 cites W2069053433 @default.
• W2149755517 cites W2086730289 @default.
• W2149755517 cites W2120971712 @default.
• W2149755517 cites W2139226057 @default.
• W2149755517 cites W2157075249 @default.
• W2149755517 cites W2163352133 @default.
• W2149755517 cites W2217599225 @default.
• W2149755517 cites W2318273724 @default.
• W2149755517 cites W4293747882 @default.
• W2149755517 cites W4296580867 @default.
• W2149755517 doi "https://doi.org/10.1111/j.1530-0277.2008.00765.x" @default.
• W2149755517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847427" @default.
• W2149755517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18702645" @default.
• W2149755517 hasPublicationYear "2008" @default.
• W2149755517 type Work @default.
• W2149755517 sameAs 2149755517 @default.
• W2149755517 citedByCount "169" @default.
• W2149755517 countsByYear W21497555172012 @default.
• W2149755517 countsByYear W21497555172013 @default.
• W2149755517 countsByYear W21497555172014 @default.
• W2149755517 countsByYear W21497555172015 @default.
• W2149755517 countsByYear W21497555172016 @default.
• W2149755517 countsByYear W21497555172017 @default.
• W2149755517 countsByYear W21497555172018 @default.
• W2149755517 countsByYear W21497555172019 @default.
• W2149755517 countsByYear W21497555172020 @default.
• W2149755517 countsByYear W21497555172021 @default.
• W2149755517 countsByYear W21497555172022 @default.
• W2149755517 countsByYear W21497555172023 @default.
• W2149755517 crossrefType "journal-article" @default.
• W2149755517 hasAuthorship W2149755517A5009474419 @default.
• W2149755517 hasAuthorship W2149755517A5020119710 @default.
• W2149755517 hasAuthorship W2149755517A5036959598 @default.
• W2149755517 hasAuthorship W2149755517A5047102441 @default.
• W2149755517 hasAuthorship W2149755517A5050008727 @default.
• W2149755517 hasAuthorship W2149755517A5086638451 @default.
• W2149755517 hasBestOaLocation W21497555172 @default.
• W2149755517 hasConcept C134018914 @default.
• W2149755517 hasConcept C140793950 @default.
• W2149755517 hasConcept C185592680 @default.
• W2149755517 hasConcept C2778555786 @default.
• W2149755517 hasConcept C2779624480 @default.
• W2149755517 hasConcept C2780161600 @default.
• W2149755517 hasConcept C2781066024 @default.
• W2149755517 hasConcept C33070731 @default.
• W2149755517 hasConcept C42219234 @default.
• W2149755517 hasConcept C55493867 @default.
• W2149755517 hasConcept C555293320 @default.
• W2149755517 hasConcept C71924100 @default.
• W2149755517 hasConcept C86803240 @default.
• W2149755517 hasConceptScore W2149755517C134018914 @default.
• W2149755517 hasConceptScore W2149755517C140793950 @default.
• W2149755517 hasConceptScore W2149755517C185592680 @default.
• W2149755517 hasConceptScore W2149755517C2778555786 @default.
• W2149755517 hasConceptScore W2149755517C2779624480 @default.
• W2149755517 hasConceptScore W2149755517C2780161600 @default.
• W2149755517 hasConceptScore W2149755517C2781066024 @default.
• W2149755517 hasConceptScore W2149755517C33070731 @default.
• W2149755517 hasConceptScore W2149755517C42219234 @default.
• W2149755517 hasConceptScore W2149755517C55493867 @default.
• W2149755517 hasConceptScore W2149755517C555293320 @default.
• W2149755517 hasConceptScore W2149755517C71924100 @default.
• W2149755517 hasConceptScore W2149755517C86803240 @default.
• W2149755517 hasIssue "10" @default.
• W2149755517 hasLocation W21497555171 @default.
• W2149755517 hasLocation W21497555172 @default.

• next