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- W2149767037 abstract "G protein α subunits are encoded by a multigene family of 16 genes that can be grouped into four classes, Gq, Gs, Gi, and G12. The Gq class is composed of four genes in mouse and human, and two of these genes,Gna11andGna15,cosegregate on mouse chromosome 10. We have characterized the gene structures of murineGna11andGna15.The two genes are tandemly duplicated in a head-to-tail array. The upstream gene,Gna11,is ubiquitously expressed, whereas expression of the downstream gene,Gna15,is restricted to hematopoietic cells. The coding sequence of each gene is contained within seven exons, and the two genes together span 43 kb, separated by 6 kb of intergenic region. We have found no evidence for alternative splicing within the coding sequence of either gene. Sequence alignments show that the positions of the six intervening sequences are conserved in the two genes, consistent withGna11andGna15arising by tandem duplication from a common progenitor gene in vertebrates. Phylogenetic trees reveal unequal evolutionary rates among α subunits of the Gq class. The rate of change is approximately six fold higher inGna15than inGna11." @default.
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- W2149767037 date "1996-02-01" @default.
- W2149767037 modified "2023-09-27" @default.
- W2149767037 title "Gene Structure of MurineGna11andGna15:Tandemly Duplicated Gq Class G Protein α Subunit Genes" @default.
- W2149767037 doi "https://doi.org/10.1006/geno.1996.0059" @default.
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