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• W2149772846 endingPage "4557" @default.
• W2149772846 startingPage "4552" @default.
• W2149772846 abstract "Expression of the POU domain protein Tst-1/Oct6 during development of glia and neurons is subject to a tight multifactorial control. Here we show that 17beta-estradiol increases the level of endogenous Tst-1/Oct6 in glial cells. This effect was mediated at the level of gene expression by an enhancer present in the 5' flanking region of the mouse gene for Tst-1/Oct6, approximately 5 kb upstream of the transcriptional start site. The enhancer contained as the functional element a sequence motif that closely resembled a classical estrogen response element. It consisted of an imperfect palindrome with a spacing of 3 bp, and was bound in vitro by activated estrogen receptor. Furthermore, this element was able to confer estrogen responsiveness when introduced into a heterologous promoter. In the Tst-1/Oct6 gene enhancer, a TPA response element was found in close proximity to the estrogen receptor binding site. As a consequence, TPA and estrogen activated transcription of the Tst-1/Oct6 gene in a synergistic manner." @default.
• W2149772846 created "2016-06-24" @default.
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• W2149772846 creator A5036749044 @default.
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• W2149772846 date "1996-11-01" @default.
• W2149772846 modified "2023-10-17" @default.
• W2149772846 title "Expression of the Gene for the POU Domain Transcription Factor Tst-1/Oct6 is Regulated by an Estrogen-Dependent Enhancer" @default.
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• W2149772846 doi "https://doi.org/10.1093/nar/24.22.4552" @default.
• W2149772846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/146271" @default.
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• W2149772846 hasPublicationYear "1996" @default.
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