Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149774429> ?p ?o ?g. }
- W2149774429 endingPage "1259" @default.
- W2149774429 startingPage "1251" @default.
- W2149774429 abstract "Aims: To investigate an association of responsiveness to clopidogrel loading dose with genotypes of cytochrome P450 (CYP) 2C19, other CYP isozymes and nongenetic factors in patients with coronary artery disease. Materials & methods: Genotyping for CYP2C19 (*2, *3 and *17), CYP3A4*1B and CYP3A5*3 variants was performed in patients (n = 237) who underwent percutaneous coronary intervention. Adenosine diphosphate-induced platelet aggregation was determined after first administration of 600 mg clopidogrel. Results: CYP2C19*2 carriers showed significantly increased residual platelet aggregation (RPA) (OR: 4.6; 95% CI: 2.5–8.7; p < 0.0001) compared with noncarriers. All other polymorphisms had no influence on RPA. For the development of a risk score for better prediction of RPA, CYP2C19*2 genotype and previously identified nongenetic risk factors (age >65 years, Type 2 diabetes mellitus, decreased left ventricular function, renal failure and acute coronary syndrome) were analyzed. Multivariable logistic regression analysis showed a significant correlation of the nongenetic factors (χ 2 = 5.32; p = 0.021) and CYP2C19*2 (χ 2 = 21.31; p < 0.0001) with high RPA, and an even higher association for the combination of both (χ 2 = 25.85; p < 0.0001). Conclusions: Prediction of responsiveness after clopidogrel loading dose may substantially be improved by adding CYP2C19*2 genotype to nongenetic risk factors." @default.
- W2149774429 created "2016-06-24" @default.
- W2149774429 creator A5000577598 @default.
- W2149774429 creator A5007815473 @default.
- W2149774429 creator A5031480577 @default.
- W2149774429 creator A5049495017 @default.
- W2149774429 creator A5055612028 @default.
- W2149774429 creator A5057183308 @default.
- W2149774429 creator A5064117382 @default.
- W2149774429 creator A5066057635 @default.
- W2149774429 creator A5079002169 @default.
- W2149774429 creator A5090714953 @default.
- W2149774429 date "2008-09-01" @default.
- W2149774429 modified "2023-09-23" @default.
- W2149774429 title "CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation" @default.
- W2149774429 cites W1538301903 @default.
- W2149774429 cites W1608256683 @default.
- W2149774429 cites W1866201138 @default.
- W2149774429 cites W1875488666 @default.
- W2149774429 cites W1918399424 @default.
- W2149774429 cites W1952796400 @default.
- W2149774429 cites W1972856183 @default.
- W2149774429 cites W1975793175 @default.
- W2149774429 cites W1988195450 @default.
- W2149774429 cites W2007108997 @default.
- W2149774429 cites W2007251996 @default.
- W2149774429 cites W2012407966 @default.
- W2149774429 cites W2038284089 @default.
- W2149774429 cites W2048615527 @default.
- W2149774429 cites W2052922809 @default.
- W2149774429 cites W2053240679 @default.
- W2149774429 cites W2053379248 @default.
- W2149774429 cites W2056384040 @default.
- W2149774429 cites W2059136191 @default.
- W2149774429 cites W2063345843 @default.
- W2149774429 cites W2081558811 @default.
- W2149774429 cites W2100209149 @default.
- W2149774429 cites W2104595603 @default.
- W2149774429 cites W2105902511 @default.
- W2149774429 cites W2113926891 @default.
- W2149774429 cites W2120603250 @default.
- W2149774429 cites W2125114764 @default.
- W2149774429 cites W2125573444 @default.
- W2149774429 cites W2129001881 @default.
- W2149774429 cites W2130350603 @default.
- W2149774429 cites W2131131247 @default.
- W2149774429 cites W2135575592 @default.
- W2149774429 cites W2140220482 @default.
- W2149774429 cites W2140728274 @default.
- W2149774429 cites W2162013709 @default.
- W2149774429 cites W2164923007 @default.
- W2149774429 cites W23524587 @default.
- W2149774429 cites W2358501499 @default.
- W2149774429 cites W3175417087 @default.
- W2149774429 doi "https://doi.org/10.2217/14622416.9.9.1251" @default.
- W2149774429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18781853" @default.
- W2149774429 hasPublicationYear "2008" @default.
- W2149774429 type Work @default.
- W2149774429 sameAs 2149774429 @default.
- W2149774429 citedByCount "200" @default.
- W2149774429 countsByYear W21497744292012 @default.
- W2149774429 countsByYear W21497744292013 @default.
- W2149774429 countsByYear W21497744292014 @default.
- W2149774429 countsByYear W21497744292015 @default.
- W2149774429 countsByYear W21497744292016 @default.
- W2149774429 countsByYear W21497744292017 @default.
- W2149774429 countsByYear W21497744292018 @default.
- W2149774429 countsByYear W21497744292019 @default.
- W2149774429 countsByYear W21497744292020 @default.
- W2149774429 countsByYear W21497744292021 @default.
- W2149774429 countsByYear W21497744292022 @default.
- W2149774429 countsByYear W21497744292023 @default.
- W2149774429 crossrefType "journal-article" @default.
- W2149774429 hasAuthorship W2149774429A5000577598 @default.
- W2149774429 hasAuthorship W2149774429A5007815473 @default.
- W2149774429 hasAuthorship W2149774429A5031480577 @default.
- W2149774429 hasAuthorship W2149774429A5049495017 @default.
- W2149774429 hasAuthorship W2149774429A5055612028 @default.
- W2149774429 hasAuthorship W2149774429A5057183308 @default.
- W2149774429 hasAuthorship W2149774429A5064117382 @default.
- W2149774429 hasAuthorship W2149774429A5066057635 @default.
- W2149774429 hasAuthorship W2149774429A5079002169 @default.
- W2149774429 hasAuthorship W2149774429A5090714953 @default.
- W2149774429 hasBestOaLocation W21497744291 @default.
- W2149774429 hasConcept C104317684 @default.
- W2149774429 hasConcept C126322002 @default.
- W2149774429 hasConcept C134018914 @default.
- W2149774429 hasConcept C135763542 @default.
- W2149774429 hasConcept C140840227 @default.
- W2149774429 hasConcept C151956035 @default.
- W2149774429 hasConcept C156957248 @default.
- W2149774429 hasConcept C164705383 @default.
- W2149774429 hasConcept C2777849778 @default.
- W2149774429 hasConcept C2778213512 @default.
- W2149774429 hasConcept C2780400711 @default.
- W2149774429 hasConcept C31467283 @default.
- W2149774429 hasConcept C49059817 @default.
- W2149774429 hasConcept C500558357 @default.