FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149777415> ?p ?o ?g. }

• W2149777415 endingPage "20140241" @default.
• W2149777415 startingPage "20140241" @default.
• W2149777415 abstract "Advances in immunoglobulin (Ig) sequencing technology are leading to new perspectives on immune system dynamics. Much research in this nascent field has focused on resolving immune responses to viral infection. However, the dynamics of B-cell diversity in early HIV infection, and in response to anti-retroviral therapy, are still poorly understood. Here, we investigate these dynamics through bulk Ig sequencing of samples collected over 2 years from a group of eight HIV-1 infected patients, five of whom received anti-retroviral therapy during the first half of the study period. We applied previously published methods for visualizing and quantifying B-cell sequence diversity, including the Gini index, and compared their efficacy to alternative measures. While we found significantly greater clonal structure in HIV-infected patients versus healthy controls, within HIV patients, we observed no significant relationships between statistics of B-cell clonal expansion and clinical variables such as viral load and CD4(+) count. Although there are many potential explanations for this, we suggest that important factors include poor sampling resolution and complex B-cell dynamics that are difficult to summarize using simple summary statistics. Importantly, we find a significant association between observed Gini indices and sequencing read depth, and we conclude that more robust analytical methods and a closer integration of experimental and theoretical work is needed to further our understanding of B-cell repertoire diversity during viral infection." @default.
• W2149777415 created "2016-06-24" @default.
• W2149777415 creator A5001478159 @default.
• W2149777415 creator A5007826002 @default.
• W2149777415 creator A5022547863 @default.
• W2149777415 creator A5026508289 @default.
• W2149777415 creator A5035508732 @default.
• W2149777415 creator A5051791661 @default.
• W2149777415 creator A5053575511 @default.
• W2149777415 creator A5061658598 @default.
• W2149777415 creator A5067056877 @default.
• W2149777415 creator A5067304304 @default.
• W2149777415 date "2015-09-05" @default.
• W2149777415 modified "2023-09-25" @default.
• W2149777415 title "Dynamics of immunoglobulin sequence diversity in HIV-1 infected individuals" @default.
• W2149777415 cites W1963745142 @default.
• W2149777415 cites W1969156908 @default.
• W2149777415 cites W1978398372 @default.
• W2149777415 cites W1991698426 @default.
• W2149777415 cites W1993986769 @default.
• W2149777415 cites W1997677784 @default.
• W2149777415 cites W2009518556 @default.
• W2149777415 cites W2018339091 @default.
• W2149777415 cites W2020094108 @default.
• W2149777415 cites W2021117977 @default.
• W2149777415 cites W2055043387 @default.
• W2149777415 cites W2056834190 @default.
• W2149777415 cites W2059583074 @default.
• W2149777415 cites W2066204229 @default.
• W2149777415 cites W2095706923 @default.
• W2149777415 cites W2097816699 @default.
• W2149777415 cites W2101637028 @default.
• W2149777415 cites W2105273832 @default.
• W2149777415 cites W2110065044 @default.
• W2149777415 cites W2125375614 @default.
• W2149777415 cites W2132375548 @default.
• W2149777415 cites W2138854899 @default.
• W2149777415 cites W2139217795 @default.
• W2149777415 cites W2142081242 @default.
• W2149777415 cites W2144420540 @default.
• W2149777415 cites W2157203934 @default.
• W2149777415 cites W2167121354 @default.
• W2149777415 cites W2170654913 @default.
• W2149777415 cites W2170747616 @default.
• W2149777415 cites W2171176459 @default.
• W2149777415 doi "https://doi.org/10.1098/rstb.2014.0241" @default.
• W2149777415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4528418" @default.
• W2149777415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26194755" @default.
• W2149777415 hasPublicationYear "2015" @default.
• W2149777415 type Work @default.
• W2149777415 sameAs 2149777415 @default.
• W2149777415 citedByCount "30" @default.
• W2149777415 countsByYear W21497774152015 @default.
• W2149777415 countsByYear W21497774152016 @default.
• W2149777415 countsByYear W21497774152017 @default.
• W2149777415 countsByYear W21497774152018 @default.
• W2149777415 countsByYear W21497774152019 @default.
• W2149777415 countsByYear W21497774152020 @default.
• W2149777415 countsByYear W21497774152022 @default.
• W2149777415 countsByYear W21497774152023 @default.
• W2149777415 crossrefType "journal-article" @default.
• W2149777415 hasAuthorship W2149777415A5001478159 @default.
• W2149777415 hasAuthorship W2149777415A5007826002 @default.
• W2149777415 hasAuthorship W2149777415A5022547863 @default.
• W2149777415 hasAuthorship W2149777415A5026508289 @default.
• W2149777415 hasAuthorship W2149777415A5035508732 @default.
• W2149777415 hasAuthorship W2149777415A5051791661 @default.
• W2149777415 hasAuthorship W2149777415A5053575511 @default.
• W2149777415 hasAuthorship W2149777415A5061658598 @default.
• W2149777415 hasAuthorship W2149777415A5067056877 @default.
• W2149777415 hasAuthorship W2149777415A5067304304 @default.
• W2149777415 hasBestOaLocation W21497774151 @default.
• W2149777415 hasConcept C104317684 @default.
• W2149777415 hasConcept C121332964 @default.
• W2149777415 hasConcept C132917006 @default.
• W2149777415 hasConcept C141231307 @default.
• W2149777415 hasConcept C142462285 @default.
• W2149777415 hasConcept C144024400 @default.
• W2149777415 hasConcept C159047783 @default.
• W2149777415 hasConcept C159654299 @default.
• W2149777415 hasConcept C19165224 @default.
• W2149777415 hasConcept C203014093 @default.
• W2149777415 hasConcept C24890656 @default.
• W2149777415 hasConcept C2778473898 @default.
• W2149777415 hasConcept C2781316041 @default.
• W2149777415 hasConcept C2910693471 @default.
• W2149777415 hasConcept C3013748606 @default.
• W2149777415 hasConcept C54355233 @default.
• W2149777415 hasConcept C70721500 @default.
• W2149777415 hasConcept C78458016 @default.
• W2149777415 hasConcept C86803240 @default.
• W2149777415 hasConcept C8769409 @default.
• W2149777415 hasConcept C8891405 @default.
• W2149777415 hasConceptScore W2149777415C104317684 @default.
• W2149777415 hasConceptScore W2149777415C121332964 @default.
• W2149777415 hasConceptScore W2149777415C132917006 @default.
• W2149777415 hasConceptScore W2149777415C141231307 @default.
• W2149777415 hasConceptScore W2149777415C142462285 @default.

• next