FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149778810> ?p ?o ?g. }

• W2149778810 endingPage "1065" @default.
• W2149778810 startingPage "1055" @default.
• W2149778810 abstract "Planarians are an ideal model system to study in vivo the dynamics of adult pluripotent stem cells. However, our knowledge of the factors necessary for regulating the ‘stemness’ of the neoblasts, the adult stem cells of planarians, is sparse. Here, we report on the characterization of the first planarian member of the LSm protein superfamily, Smed-SmB, which is expressed in stem cells and neurons in Schmidtea mediterranea. LSm proteins are highly conserved key players of the splicing machinery. Our study shows that Smed-SmB protein, which is localized in the nucleus and the chromatoid body of stem cells, is required to safeguard the proliferative ability of the neoblasts. The chromatoid body, a cytoplasmatic ribonucleoprotein complex, is an essential regulator of the RNA metabolism required for the maintenance of metazoan germ cells. However, planarian neoblasts and neurons also rely on its functions. Remarkably, Smed-SmB dsRNA-mediated knockdown results in a rapid loss of organization of the chromatoid body, an impairment of the ability to post-transcriptionally process the transcripts of Smed-CycB, and a severe proliferative failure of the neoblasts. This chain of events leads to a quick depletion of the neoblast pool, resulting in a lethal phenotype for both regenerating and intact animals. In summary, our results suggest that Smed-SmB is an essential component of the chromatoid body, crucial to ensure a proper RNA metabolism and essential for stem cell proliferation." @default.
• W2149778810 created "2016-06-24" @default.
• W2149778810 creator A5006205463 @default.
• W2149778810 creator A5009739201 @default.
• W2149778810 creator A5019515014 @default.
• W2149778810 creator A5038452833 @default.
• W2149778810 creator A5054555680 @default.
• W2149778810 creator A5059854044 @default.
• W2149778810 creator A5078962332 @default.
• W2149778810 date "2010-04-01" @default.
• W2149778810 modified "2023-10-17" @default.
• W2149778810 title "Smed-SmB, a member of the LSm protein superfamily, is essential for chromatoid body organization and planarian stem cell proliferation" @default.
• W2149778810 cites W1602313672 @default.
• W2149778810 cites W1912418335 @default.
• W2149778810 cites W1968160161 @default.
• W2149778810 cites W1968405891 @default.
• W2149778810 cites W1970706402 @default.
• W2149778810 cites W1982118908 @default.
• W2149778810 cites W1986260964 @default.
• W2149778810 cites W1988498926 @default.
• W2149778810 cites W1993578809 @default.
• W2149778810 cites W1997279341 @default.
• W2149778810 cites W1997389247 @default.
• W2149778810 cites W2000541788 @default.
• W2149778810 cites W2000732845 @default.
• W2149778810 cites W2002653689 @default.
• W2149778810 cites W2012157613 @default.
• W2149778810 cites W2023719014 @default.
• W2149778810 cites W2025404424 @default.
• W2149778810 cites W2031504305 @default.
• W2149778810 cites W2034960289 @default.
• W2149778810 cites W2039435553 @default.
• W2149778810 cites W2041871675 @default.
• W2149778810 cites W2042480114 @default.
• W2149778810 cites W2048206106 @default.
• W2149778810 cites W2049284181 @default.
• W2149778810 cites W2056701775 @default.
• W2149778810 cites W2058985658 @default.
• W2149778810 cites W2061717554 @default.
• W2149778810 cites W2063778837 @default.
• W2149778810 cites W2064922804 @default.
• W2149778810 cites W2067192695 @default.
• W2149778810 cites W2072590456 @default.
• W2149778810 cites W2074658822 @default.
• W2149778810 cites W2084288930 @default.
• W2149778810 cites W2089083573 @default.
• W2149778810 cites W2089698425 @default.
• W2149778810 cites W2093339780 @default.
• W2149778810 cites W2095220436 @default.
• W2149778810 cites W2103393662 @default.
• W2149778810 cites W2107498377 @default.
• W2149778810 cites W2128683321 @default.
• W2149778810 cites W2129995373 @default.
• W2149778810 cites W2131934556 @default.
• W2149778810 cites W2136175548 @default.
• W2149778810 cites W2150465697 @default.
• W2149778810 cites W2153321121 @default.
• W2149778810 cites W2157724060 @default.
• W2149778810 cites W2160361990 @default.
• W2149778810 cites W2161282555 @default.
• W2149778810 cites W2166999605 @default.
• W2149778810 cites W2169952584 @default.
• W2149778810 cites W2783760208 @default.
• W2149778810 cites W4232392880 @default.
• W2149778810 cites W4245612329 @default.
• W2149778810 doi "https://doi.org/10.1242/dev.042564" @default.
• W2149778810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20215344" @default.
• W2149778810 hasPublicationYear "2010" @default.
• W2149778810 type Work @default.
• W2149778810 sameAs 2149778810 @default.
• W2149778810 citedByCount "63" @default.
• W2149778810 countsByYear W21497788102012 @default.
• W2149778810 countsByYear W21497788102013 @default.
• W2149778810 countsByYear W21497788102014 @default.
• W2149778810 countsByYear W21497788102015 @default.
• W2149778810 countsByYear W21497788102016 @default.
• W2149778810 countsByYear W21497788102017 @default.
• W2149778810 countsByYear W21497788102018 @default.
• W2149778810 countsByYear W21497788102019 @default.
• W2149778810 countsByYear W21497788102020 @default.
• W2149778810 countsByYear W21497788102021 @default.
• W2149778810 countsByYear W21497788102022 @default.
• W2149778810 countsByYear W21497788102023 @default.
• W2149778810 crossrefType "journal-article" @default.
• W2149778810 hasAuthorship W2149778810A5006205463 @default.
• W2149778810 hasAuthorship W2149778810A5009739201 @default.
• W2149778810 hasAuthorship W2149778810A5019515014 @default.
• W2149778810 hasAuthorship W2149778810A5038452833 @default.
• W2149778810 hasAuthorship W2149778810A5054555680 @default.
• W2149778810 hasAuthorship W2149778810A5059854044 @default.
• W2149778810 hasAuthorship W2149778810A5078962332 @default.
• W2149778810 hasBestOaLocation W21497788101 @default.
• W2149778810 hasConcept C104317684 @default.
• W2149778810 hasConcept C107459253 @default.
• W2149778810 hasConcept C145103041 @default.
• W2149778810 hasConcept C171056886 @default.
• W2149778810 hasConcept C173396325 @default.
• W2149778810 hasConcept C190283241 @default.

• next