Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149781355> ?p ?o ?g. }
- W2149781355 endingPage "270" @default.
- W2149781355 startingPage "261" @default.
- W2149781355 abstract "Protein kinase C (PKC) is present in high concentrations in neuronal tissues and participates in various neuronal functions. Ten isoforms have so far been identified and each PKC isoform may be activated by a variety of stimuli. By immunoblot analysis the presence of PKC isoforms was examined in dissociated cell cultures of the hippocampus and during the development in vivo. As soon as embryonic day 17 the hippocampus contains detectable amounts of PKC ϵ and ζ and low levels of PKC α. PKC β and γ appear during the first and second post-natal week. All isoforms progressively increase until the adult age. Cultures of hippocampal neurons derived from rat embryos express PKC α, ϵ and ζ whereas PKC β and γ are undetectable; a distinct pattern is observed in cultures of hippocampal glial cells. The neuronal levels of PKC α, ϵ and ζ increase during the period in culture and are enhanced when hippocampal neurons are exposed to the continuous presence of basic fibroblast growth factor. Immunofluorescence of PKC ϵ and ζ occupies all the cytoplasmic neuronal compartment. The early expression of some PKC isoforms in cultures of post-mitotic hippocampal neurons suggest their involvement in morphological events that occur during this period, in particular the neuritic outgrowth." @default.
- W2149781355 created "2016-06-24" @default.
- W2149781355 creator A5006039101 @default.
- W2149781355 creator A5020714874 @default.
- W2149781355 date "1997-02-10" @default.
- W2149781355 modified "2023-09-25" @default.
- W2149781355 title "Differential expression of PKC isoforms in hippocampal neuronal cultures: modifications after basic FGF treatment" @default.
- W2149781355 cites W148785554 @default.
- W2149781355 cites W1503786837 @default.
- W2149781355 cites W1539826875 @default.
- W2149781355 cites W1555146912 @default.
- W2149781355 cites W1574914587 @default.
- W2149781355 cites W1808628558 @default.
- W2149781355 cites W1814732951 @default.
- W2149781355 cites W1929472049 @default.
- W2149781355 cites W1975695296 @default.
- W2149781355 cites W1977311938 @default.
- W2149781355 cites W1977812840 @default.
- W2149781355 cites W1981023296 @default.
- W2149781355 cites W1982506453 @default.
- W2149781355 cites W1984532381 @default.
- W2149781355 cites W1985864666 @default.
- W2149781355 cites W1986387695 @default.
- W2149781355 cites W1987700551 @default.
- W2149781355 cites W1988111588 @default.
- W2149781355 cites W1998225973 @default.
- W2149781355 cites W2001196018 @default.
- W2149781355 cites W2001396103 @default.
- W2149781355 cites W200140000 @default.
- W2149781355 cites W2003632139 @default.
- W2149781355 cites W2009165454 @default.
- W2149781355 cites W2010296954 @default.
- W2149781355 cites W2015571904 @default.
- W2149781355 cites W2019872692 @default.
- W2149781355 cites W2020200340 @default.
- W2149781355 cites W2027399729 @default.
- W2149781355 cites W2027905968 @default.
- W2149781355 cites W2036026294 @default.
- W2149781355 cites W2043762471 @default.
- W2149781355 cites W2050259906 @default.
- W2149781355 cites W2052526013 @default.
- W2149781355 cites W2053213696 @default.
- W2149781355 cites W2054280279 @default.
- W2149781355 cites W2055206305 @default.
- W2149781355 cites W2056470306 @default.
- W2149781355 cites W2057135745 @default.
- W2149781355 cites W2063862732 @default.
- W2149781355 cites W2065761783 @default.
- W2149781355 cites W2077499744 @default.
- W2149781355 cites W2081731786 @default.
- W2149781355 cites W2091543295 @default.
- W2149781355 cites W2100837269 @default.
- W2149781355 cites W2101108802 @default.
- W2149781355 cites W2115756131 @default.
- W2149781355 cites W2128635872 @default.
- W2149781355 cites W2178730998 @default.
- W2149781355 cites W2373952101 @default.
- W2149781355 doi "https://doi.org/10.1016/s0197-0186(96)00095-2" @default.
- W2149781355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9041557" @default.
- W2149781355 hasPublicationYear "1997" @default.
- W2149781355 type Work @default.
- W2149781355 sameAs 2149781355 @default.
- W2149781355 citedByCount "24" @default.
- W2149781355 countsByYear W21497813552013 @default.
- W2149781355 countsByYear W21497813552014 @default.
- W2149781355 countsByYear W21497813552015 @default.
- W2149781355 countsByYear W21497813552017 @default.
- W2149781355 countsByYear W21497813552021 @default.
- W2149781355 crossrefType "journal-article" @default.
- W2149781355 hasAuthorship W2149781355A5006039101 @default.
- W2149781355 hasAuthorship W2149781355A5020714874 @default.
- W2149781355 hasConcept C104317684 @default.
- W2149781355 hasConcept C148762608 @default.
- W2149781355 hasConcept C169760540 @default.
- W2149781355 hasConcept C184235292 @default.
- W2149781355 hasConcept C195794163 @default.
- W2149781355 hasConcept C2781161787 @default.
- W2149781355 hasConcept C53345823 @default.
- W2149781355 hasConcept C55493867 @default.
- W2149781355 hasConcept C86803240 @default.
- W2149781355 hasConcept C95444343 @default.
- W2149781355 hasConceptScore W2149781355C104317684 @default.
- W2149781355 hasConceptScore W2149781355C148762608 @default.
- W2149781355 hasConceptScore W2149781355C169760540 @default.
- W2149781355 hasConceptScore W2149781355C184235292 @default.
- W2149781355 hasConceptScore W2149781355C195794163 @default.
- W2149781355 hasConceptScore W2149781355C2781161787 @default.
- W2149781355 hasConceptScore W2149781355C53345823 @default.
- W2149781355 hasConceptScore W2149781355C55493867 @default.
- W2149781355 hasConceptScore W2149781355C86803240 @default.
- W2149781355 hasConceptScore W2149781355C95444343 @default.
- W2149781355 hasIssue "3" @default.
- W2149781355 hasLocation W21497813551 @default.
- W2149781355 hasLocation W21497813552 @default.
- W2149781355 hasOpenAccess W2149781355 @default.
- W2149781355 hasPrimaryLocation W21497813551 @default.
- W2149781355 hasRelatedWork W1501306774 @default.
- W2149781355 hasRelatedWork W1964912033 @default.