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- W2149782564 abstract "ABSTRACT: Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for sub-populations of trophoblast cells, depending on gestational stage and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation." @default.
- W2149782564 created "2016-06-24" @default.
- W2149782564 creator A5013943720 @default.
- W2149782564 creator A5052453078 @default.
- W2149782564 creator A5091268008 @default.
- W2149782564 date "1987-09-01" @default.
- W2149782564 modified "2023-10-18" @default.
- W2149782564 title "Major Histocompatibility Antigens on Trophoblast and Their Regulation: Implications in the Maternal-Fetal Relationship" @default.
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- W2149782564 doi "https://doi.org/10.1111/j.1600-0897.1987.tb00143.x" @default.
- W2149782564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3322066" @default.