FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149783280> ?p ?o ?g. }

• W2149783280 endingPage "R626" @default.
• W2149783280 startingPage "R614" @default.
• W2149783280 abstract "To what extent hypoxia alters the adenosine (ADO) system and impacts on cardiac function during embryogenesis is not known. Ectonucleoside triphosphate diphosphohydrolase (CD39), ecto-5′-nucleotidase (CD73), adenosine kinase (AdK), adenosine deaminase (ADA), equilibrative (ENT1,3,4), and concentrative (CNT3) transporters and ADO receptors A 1 , A 2A , A 2B , and A 3 constitute the adenosinergic system. During the first 4 days of development chick embryos were exposed in ovo to normoxia followed or not followed by 6 h hypoxia. ADO and glycogen content and mRNA expression of the genes were determined in the atria, ventricle, and outflow tract of the normoxic (N) and hypoxic (H) hearts. Electrocardiogram and ventricular shortening of the N and H hearts were recorded ex vivo throughout anoxia/reoxygenation ± ADO. Under basal conditions, CD39, CD73, ADK, ADA, ENT1,3,4, CNT3, and ADO receptors were differentially expressed in the atria, ventricle, and outflow tract. In H hearts ADO level doubled, glycogen decreased, and mRNA expression of all the investigated genes was downregulated by hypoxia, except for A 2A and A 3 receptors. The most rapid and marked downregulation was found for ADA in atria. H hearts were arrhythmic and more vulnerable to anoxia-reoxygenation than N hearts. Despite downregulation of the genes, exposure of isolated hearts to ADO 1) preserved glycogen through activation of A 1 receptor and Akt-GSK3β-GS pathway, 2) prolonged activity and improved conduction under anoxia, and 3) restored QT interval in H hearts. Thus hypoxia-induced downregulation of the adenosinergic system can be regarded as a coping response, limiting the detrimental accumulation of ADO without interfering with ADO signaling." @default.
• W2149783280 created "2016-06-24" @default.
• W2149783280 creator A5018092946 @default.
• W2149783280 creator A5018584263 @default.
• W2149783280 creator A5050112645 @default.
• W2149783280 date "2015-04-01" @default.
• W2149783280 modified "2023-09-24" @default.
• W2149783280 title "A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance" @default.
• W2149783280 cites W1540099187 @default.
• W2149783280 cites W1596640352 @default.
• W2149783280 cites W1776221901 @default.
• W2149783280 cites W1964192278 @default.
• W2149783280 cites W1966155265 @default.
• W2149783280 cites W1970701128 @default.
• W2149783280 cites W1972783950 @default.
• W2149783280 cites W1973710828 @default.
• W2149783280 cites W1974998794 @default.
• W2149783280 cites W1976469253 @default.
• W2149783280 cites W1984250382 @default.
• W2149783280 cites W1990143242 @default.
• W2149783280 cites W1990218063 @default.
• W2149783280 cites W1991514603 @default.
• W2149783280 cites W1993039541 @default.
• W2149783280 cites W1993691751 @default.
• W2149783280 cites W1995734429 @default.
• W2149783280 cites W1997299202 @default.
• W2149783280 cites W1997412397 @default.
• W2149783280 cites W2002357831 @default.
• W2149783280 cites W2007548120 @default.
• W2149783280 cites W2017467571 @default.
• W2149783280 cites W2025323169 @default.
• W2149783280 cites W2030099655 @default.
• W2149783280 cites W2032189169 @default.
• W2149783280 cites W2032303762 @default.
• W2149783280 cites W2032350037 @default.
• W2149783280 cites W2041012306 @default.
• W2149783280 cites W2041610189 @default.
• W2149783280 cites W2042138655 @default.
• W2149783280 cites W2051481642 @default.
• W2149783280 cites W2058743421 @default.
• W2149783280 cites W2059715006 @default.
• W2149783280 cites W2060700610 @default.
• W2149783280 cites W2064636853 @default.
• W2149783280 cites W2069673081 @default.
• W2149783280 cites W2070832004 @default.
• W2149783280 cites W2071032140 @default.
• W2149783280 cites W2071186790 @default.
• W2149783280 cites W2073097810 @default.
• W2149783280 cites W2079217665 @default.
• W2149783280 cites W2080245518 @default.
• W2149783280 cites W2087668349 @default.
• W2149783280 cites W2089455375 @default.
• W2149783280 cites W2098209017 @default.
• W2149783280 cites W2110753523 @default.
• W2149783280 cites W2113169549 @default.
• W2149783280 cites W2133041463 @default.
• W2149783280 cites W2140034535 @default.
• W2149783280 cites W2152287187 @default.
• W2149783280 cites W2156379922 @default.
• W2149783280 cites W2159300248 @default.
• W2149783280 cites W2161513183 @default.
• W2149783280 cites W2162878054 @default.
• W2149783280 cites W2165374059 @default.
• W2149783280 cites W2167993476 @default.
• W2149783280 cites W2169825634 @default.
• W2149783280 cites W2214023928 @default.
• W2149783280 cites W2252780427 @default.
• W2149783280 cites W2264366818 @default.
• W2149783280 cites W2277824238 @default.
• W2149783280 cites W2418149211 @default.
• W2149783280 cites W313032012 @default.
• W2149783280 doi "https://doi.org/10.1152/ajpregu.00423.2014" @default.
• W2149783280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4386002" @default.
• W2149783280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25632022" @default.
• W2149783280 hasPublicationYear "2015" @default.
• W2149783280 type Work @default.
• W2149783280 sameAs 2149783280 @default.
• W2149783280 citedByCount "3" @default.
• W2149783280 countsByYear W21497832802016 @default.
• W2149783280 countsByYear W21497832802018 @default.
• W2149783280 countsByYear W21497832802020 @default.
• W2149783280 crossrefType "journal-article" @default.
• W2149783280 hasAuthorship W2149783280A5018092946 @default.
• W2149783280 hasAuthorship W2149783280A5018584263 @default.
• W2149783280 hasAuthorship W2149783280A5050112645 @default.
• W2149783280 hasBestOaLocation W21497832802 @default.
• W2149783280 hasConcept C104317684 @default.
• W2149783280 hasConcept C126322002 @default.
• W2149783280 hasConcept C127561419 @default.
• W2149783280 hasConcept C134018914 @default.
• W2149783280 hasConcept C170493617 @default.
• W2149783280 hasConcept C178790620 @default.
• W2149783280 hasConcept C185592680 @default.
• W2149783280 hasConcept C2776991684 @default.
• W2149783280 hasConcept C2776992512 @default.
• W2149783280 hasConcept C2777499176 @default.
• W2149783280 hasConcept C2778938600 @default.
• W2149783280 hasConcept C540031477 @default.

• next