Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149785911> ?p ?o ?g. }
- W2149785911 endingPage "528" @default.
- W2149785911 startingPage "521" @default.
- W2149785911 abstract "Small, noncoding, microRNAs (miRNAs) have emerged as key mediators of posttranscriptional gene silencing in both pathogenic and pathological aspects of ischemic stroke biology. In stroke etiology, miRNA have distinct expression patterns that modulate pathogenic processes including atherosclerosis (miR-21, miR-126), hyperlipidemia (miR-33, miR-125a-5p), hypertension (miR-155), and plaque rupture (miR-222, miR-210). Following focal cerebral ischemia, significant changes in the miRNA transcriptome, independent of an effect on expression of miRNA machinery, implicate miRNA in the pathological cascade of events that include blood brain barrier disruption (miR-15a) and caspase mediated cell death signaling (miR-497). Early activation of miR-200 family members improves neural cell survival via prolyl hydroxylase mRNA silencing and subsequent HIF-1α stabilization. Pro- (miR-125b) and anti-inflammatory (miR-26a, -34a, -145, and let-7b) miRNA may also be manipulated to positively influence stroke outcomes. Recent examples of successfully implemented miRNA-therapeutics direct the future of gene therapy and offer new therapeutic strategies by regulating large sets of genes in related pathways of the ischemic stroke cascade." @default.
- W2149785911 created "2016-06-24" @default.
- W2149785911 creator A5029107258 @default.
- W2149785911 creator A5041966279 @default.
- W2149785911 date "2011-05-01" @default.
- W2149785911 modified "2023-09-25" @default.
- W2149785911 title "MicroRNA in ischemic stroke etiology and pathology" @default.
- W2149785911 cites W144423133 @default.
- W2149785911 cites W1809660494 @default.
- W2149785911 cites W1965306643 @default.
- W2149785911 cites W1968102833 @default.
- W2149785911 cites W1971234948 @default.
- W2149785911 cites W1971520781 @default.
- W2149785911 cites W1980269624 @default.
- W2149785911 cites W1986540698 @default.
- W2149785911 cites W1990752520 @default.
- W2149785911 cites W1992638032 @default.
- W2149785911 cites W1992639010 @default.
- W2149785911 cites W1995023661 @default.
- W2149785911 cites W2001760048 @default.
- W2149785911 cites W2004247123 @default.
- W2149785911 cites W2005532281 @default.
- W2149785911 cites W2009432050 @default.
- W2149785911 cites W2009812062 @default.
- W2149785911 cites W2014474485 @default.
- W2149785911 cites W2014497476 @default.
- W2149785911 cites W2015137536 @default.
- W2149785911 cites W2015219110 @default.
- W2149785911 cites W2018146396 @default.
- W2149785911 cites W2020576064 @default.
- W2149785911 cites W2021988159 @default.
- W2149785911 cites W2026581189 @default.
- W2149785911 cites W2027052432 @default.
- W2149785911 cites W2028067727 @default.
- W2149785911 cites W2031014255 @default.
- W2149785911 cites W2032345537 @default.
- W2149785911 cites W2032766715 @default.
- W2149785911 cites W2035195993 @default.
- W2149785911 cites W2038051506 @default.
- W2149785911 cites W2038469589 @default.
- W2149785911 cites W2038707186 @default.
- W2149785911 cites W2042004955 @default.
- W2149785911 cites W2046012789 @default.
- W2149785911 cites W2051389951 @default.
- W2149785911 cites W2052671730 @default.
- W2149785911 cites W2054791783 @default.
- W2149785911 cites W2060481603 @default.
- W2149785911 cites W2070665570 @default.
- W2149785911 cites W2075728036 @default.
- W2149785911 cites W2083381199 @default.
- W2149785911 cites W2087789406 @default.
- W2149785911 cites W2090219560 @default.
- W2149785911 cites W2094626102 @default.
- W2149785911 cites W2095226068 @default.
- W2149785911 cites W2095528090 @default.
- W2149785911 cites W2096166765 @default.
- W2149785911 cites W2097103756 @default.
- W2149785911 cites W2097837136 @default.
- W2149785911 cites W2103052577 @default.
- W2149785911 cites W2111585311 @default.
- W2149785911 cites W2112192177 @default.
- W2149785911 cites W2112785261 @default.
- W2149785911 cites W2117307804 @default.
- W2149785911 cites W2119337308 @default.
- W2149785911 cites W2122318491 @default.
- W2149785911 cites W2123177387 @default.
- W2149785911 cites W2125622673 @default.
- W2149785911 cites W2126255129 @default.
- W2149785911 cites W2126732736 @default.
- W2149785911 cites W2132762707 @default.
- W2149785911 cites W2139128338 @default.
- W2149785911 cites W2142310248 @default.
- W2149785911 cites W2143915650 @default.
- W2149785911 cites W2144154026 @default.
- W2149785911 cites W2147204790 @default.
- W2149785911 cites W2150832685 @default.
- W2149785911 cites W2154088758 @default.
- W2149785911 cites W2156843318 @default.
- W2149785911 cites W2159036039 @default.
- W2149785911 cites W2160913143 @default.
- W2149785911 cites W2161068194 @default.
- W2149785911 cites W2162137461 @default.
- W2149785911 cites W2163294226 @default.
- W2149785911 cites W2165764599 @default.
- W2149785911 cites W2167090083 @default.
- W2149785911 cites W2167654125 @default.
- W2149785911 cites W2169079203 @default.
- W2149785911 cites W2170068628 @default.
- W2149785911 cites W2172100996 @default.
- W2149785911 cites W2322095705 @default.
- W2149785911 cites W2614781785 @default.
- W2149785911 doi "https://doi.org/10.1152/physiolgenomics.00158.2010" @default.
- W2149785911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3110894" @default.
- W2149785911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20841499" @default.
- W2149785911 hasPublicationYear "2011" @default.
- W2149785911 type Work @default.
- W2149785911 sameAs 2149785911 @default.
- W2149785911 citedByCount "223" @default.