Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149787575> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2149787575 abstract "This pilot study was undertaken to evaluate the effect of high dose-per-fraction radiotherapy given to the tumor primary concurrently with conventional fractionated radiotherapy to the electively irradiated regional lymph nodes (concomitant boost). This article reports the late results of toxicity and survival.Fifty-nine patients with histologically proven clinical Stage T3-T4, N1-3 nonsmall cell lung cancer were prospectively enrolled in this study. Fifty-six were evaluable for late effects. The treatment delivered 2.68 Gy daily to the primary tumor, 5 days a week, to a total dose of 75 Gy in 28 fractions in 5.5 weeks. At the same treatment sessions, the electively irradiated nodal areas received 1.8 Gy daily, 5 days per week, to a total dose of 50.4 Gy. All doses were calculated with heterogeneity corrections for lung density.Presently, one patient remains alive at 7.7 years. Median survival was 10.0 months with 1-, 2-, 3-, and 5-year survival rates of 41%, 25%, 18%, and 4%, respectively. Three patients developed severe late complications, including pulmonary fibrosis and osteonecrosis. The remainder of the patients, however, developed only grade 1 or 2 pulmonary fibrosis and/or pneumonitis.We conclude that concomitant boost radiotherapy in the manner reported resulted in acceptable late toxicity. The 2- and 3-year survivals compared favorably with the best-reported results in the literature with either hyperfractionated or chemoradiotherapy treatment. Studies that deliver higher radiotherapy doses to the gross tumor combined with chemotherapy are in order." @default.
- W2149787575 created "2016-06-24" @default.
- W2149787575 creator A5031524425 @default.
- W2149787575 creator A5033516554 @default.
- W2149787575 creator A5047499575 @default.
- W2149787575 creator A5060036184 @default.
- W2149787575 creator A5086999623 @default.
- W2149787575 date "1995-02-01" @default.
- W2149787575 modified "2023-09-23" @default.
- W2149787575 title "Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the radiation therapy oncology group (RTOG 83-12): long-term results" @default.
- W2149787575 cites W1971747664 @default.
- W2149787575 cites W1972125775 @default.
- W2149787575 cites W1978156658 @default.
- W2149787575 cites W1979300931 @default.
- W2149787575 cites W2016035176 @default.
- W2149787575 cites W2016694541 @default.
- W2149787575 cites W2025080501 @default.
- W2149787575 cites W2032844747 @default.
- W2149787575 cites W2040399379 @default.
- W2149787575 cites W2047561717 @default.
- W2149787575 cites W2055228153 @default.
- W2149787575 cites W2068065954 @default.
- W2149787575 cites W2070718488 @default.
- W2149787575 cites W2105150213 @default.
- W2149787575 cites W2105365583 @default.
- W2149787575 cites W2138310931 @default.
- W2149787575 cites W2226077283 @default.
- W2149787575 cites W2312703485 @default.
- W2149787575 cites W2317448174 @default.
- W2149787575 cites W3146401935 @default.
- W2149787575 doi "https://doi.org/10.1016/0360-3016(94)00543-5" @default.
- W2149787575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7860394" @default.
- W2149787575 hasPublicationYear "1995" @default.
- W2149787575 type Work @default.
- W2149787575 sameAs 2149787575 @default.
- W2149787575 citedByCount "47" @default.
- W2149787575 countsByYear W21497875752012 @default.
- W2149787575 countsByYear W21497875752013 @default.
- W2149787575 countsByYear W21497875752014 @default.
- W2149787575 countsByYear W21497875752015 @default.
- W2149787575 countsByYear W21497875752017 @default.
- W2149787575 countsByYear W21497875752018 @default.
- W2149787575 countsByYear W21497875752019 @default.
- W2149787575 crossrefType "journal-article" @default.
- W2149787575 hasAuthorship W2149787575A5031524425 @default.
- W2149787575 hasAuthorship W2149787575A5033516554 @default.
- W2149787575 hasAuthorship W2149787575A5047499575 @default.
- W2149787575 hasAuthorship W2149787575A5060036184 @default.
- W2149787575 hasAuthorship W2149787575A5086999623 @default.
- W2149787575 hasConcept C126322002 @default.
- W2149787575 hasConcept C141071460 @default.
- W2149787575 hasConcept C143998085 @default.
- W2149787575 hasConcept C146357865 @default.
- W2149787575 hasConcept C151730666 @default.
- W2149787575 hasConcept C2776256026 @default.
- W2149787575 hasConcept C2776694085 @default.
- W2149787575 hasConcept C2777714996 @default.
- W2149787575 hasConcept C2778424827 @default.
- W2149787575 hasConcept C2779384505 @default.
- W2149787575 hasConcept C2779524853 @default.
- W2149787575 hasConcept C509974204 @default.
- W2149787575 hasConcept C71924100 @default.
- W2149787575 hasConcept C86803240 @default.
- W2149787575 hasConceptScore W2149787575C126322002 @default.
- W2149787575 hasConceptScore W2149787575C141071460 @default.
- W2149787575 hasConceptScore W2149787575C143998085 @default.
- W2149787575 hasConceptScore W2149787575C146357865 @default.
- W2149787575 hasConceptScore W2149787575C151730666 @default.
- W2149787575 hasConceptScore W2149787575C2776256026 @default.
- W2149787575 hasConceptScore W2149787575C2776694085 @default.
- W2149787575 hasConceptScore W2149787575C2777714996 @default.
- W2149787575 hasConceptScore W2149787575C2778424827 @default.
- W2149787575 hasConceptScore W2149787575C2779384505 @default.
- W2149787575 hasConceptScore W2149787575C2779524853 @default.
- W2149787575 hasConceptScore W2149787575C509974204 @default.
- W2149787575 hasConceptScore W2149787575C71924100 @default.
- W2149787575 hasConceptScore W2149787575C86803240 @default.
- W2149787575 hasLocation W21497875751 @default.
- W2149787575 hasLocation W21497875752 @default.
- W2149787575 hasOpenAccess W2149787575 @default.
- W2149787575 hasPrimaryLocation W21497875751 @default.
- W2149787575 hasRelatedWork W2071189140 @default.
- W2149787575 hasRelatedWork W2143354789 @default.
- W2149787575 hasRelatedWork W2277416945 @default.
- W2149787575 hasRelatedWork W2357991707 @default.
- W2149787575 hasRelatedWork W2386230446 @default.
- W2149787575 hasRelatedWork W3029134543 @default.
- W2149787575 hasRelatedWork W3029180858 @default.
- W2149787575 hasRelatedWork W3138182626 @default.
- W2149787575 hasRelatedWork W1899415052 @default.
- W2149787575 hasRelatedWork W2184370981 @default.
- W2149787575 isParatext "false" @default.
- W2149787575 isRetracted "false" @default.
- W2149787575 magId "2149787575" @default.
- W2149787575 workType "article" @default.