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- W2149791183 abstract "Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic." @default.
- W2149791183 created "2016-06-24" @default.
- W2149791183 creator A5035756733 @default.
- W2149791183 date "2001-03-08" @default.
- W2149791183 modified "2023-10-08" @default.
- W2149791183 title "Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine" @default.
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- W2149791183 doi "https://doi.org/10.1126/science.1058915" @default.
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