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• W2149791465 startingPage "e1003721" @default.
• W2149791465 abstract "RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, which caused embryonic lethality, augmented cytosolic RNA-mediated innate signaling and facilitated RNA virus replication. DDX24 preferentially bound to RNA rather than DNA species and influenced signaling by associating with adaptor proteins FADD and RIP1. These events preferentially impeded IRF7 activity, an essential transcription factor for type I IFN production. Our data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease." @default.
• W2149791465 created "2016-06-24" @default.
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• W2149791465 date "2013-10-31" @default.
• W2149791465 modified "2023-10-13" @default.
• W2149791465 title "DDX24 Negatively Regulates Cytosolic RNA-Mediated Innate Immune Signaling" @default.
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• W2149791465 doi "https://doi.org/10.1371/journal.ppat.1003721" @default.
• W2149791465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814876" @default.
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• W2149791465 hasPublicationYear "2013" @default.
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