FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149792725> ?p ?o ?g. }

• W2149792725 endingPage "215" @default.
• W2149792725 startingPage "207" @default.
• W2149792725 abstract "The potential therapeutic value of combinatorial regimens based on an EGF receptor tyrosine kinase inhibitor (TKI) and autophagy inducing drugs was evaluated by comparing their molecular impacts on H1299 and A549 non-small cell lung cancer (NSCLC) cells, which overexpress wild type EGF receptor, but are either deficient or have wild type p53 alleles, respectively. We show that H1299 cells display a considerably lower sensitivity to erlotinib treatment, which can be restored by combining erlotinib with rapamycin or with imatinib, though to a lesser extent. Cytotoxicity was associated with increased autophagy and hyperpolarization of the mitochondrial membrane potential. Therefore, combining an EGF receptor directed TKI with an autophagy-inducing drug, preferably, rapamycin, might be beneficial in treating poor responding NSCLC patients." @default.
• W2149792725 created "2016-06-24" @default.
• W2149792725 creator A5037950672 @default.
• W2149792725 creator A5040158833 @default.
• W2149792725 creator A5051875568 @default.
• W2149792725 creator A5062661552 @default.
• W2149792725 creator A5065506910 @default.
• W2149792725 creator A5090671056 @default.
• W2149792725 date "2011-11-01" @default.
• W2149792725 modified "2023-10-01" @default.
• W2149792725 title "Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer" @default.
• W2149792725 cites W1964877976 @default.
• W2149792725 cites W1966238464 @default.
• W2149792725 cites W1967394241 @default.
• W2149792725 cites W1974584534 @default.
• W2149792725 cites W1981711832 @default.
• W2149792725 cites W2025137878 @default.
• W2149792725 cites W2031548070 @default.
• W2149792725 cites W2032074009 @default.
• W2149792725 cites W2038405639 @default.
• W2149792725 cites W2057106513 @default.
• W2149792725 cites W2071093488 @default.
• W2149792725 cites W2078911476 @default.
• W2149792725 cites W2089624362 @default.
• W2149792725 cites W2111065680 @default.
• W2149792725 cites W2114744705 @default.
• W2149792725 cites W2119524272 @default.
• W2149792725 cites W2141855935 @default.
• W2149792725 cites W2153607816 @default.
• W2149792725 doi "https://doi.org/10.1016/j.canlet.2011.07.002" @default.
• W2149792725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21807458" @default.
• W2149792725 hasPublicationYear "2011" @default.
• W2149792725 type Work @default.
• W2149792725 sameAs 2149792725 @default.
• W2149792725 citedByCount "68" @default.
• W2149792725 countsByYear W21497927252012 @default.
• W2149792725 countsByYear W21497927252013 @default.
• W2149792725 countsByYear W21497927252014 @default.
• W2149792725 countsByYear W21497927252015 @default.
• W2149792725 countsByYear W21497927252016 @default.
• W2149792725 countsByYear W21497927252017 @default.
• W2149792725 countsByYear W21497927252018 @default.
• W2149792725 countsByYear W21497927252019 @default.
• W2149792725 countsByYear W21497927252020 @default.
• W2149792725 countsByYear W21497927252021 @default.
• W2149792725 countsByYear W21497927252022 @default.
• W2149792725 countsByYear W21497927252023 @default.
• W2149792725 crossrefType "journal-article" @default.
• W2149792725 hasAuthorship W2149792725A5037950672 @default.
• W2149792725 hasAuthorship W2149792725A5040158833 @default.
• W2149792725 hasAuthorship W2149792725A5051875568 @default.
• W2149792725 hasAuthorship W2149792725A5062661552 @default.
• W2149792725 hasAuthorship W2149792725A5065506910 @default.
• W2149792725 hasAuthorship W2149792725A5090671056 @default.
• W2149792725 hasConcept C121608353 @default.
• W2149792725 hasConcept C143998085 @default.
• W2149792725 hasConcept C170493617 @default.
• W2149792725 hasConcept C190283241 @default.
• W2149792725 hasConcept C203522944 @default.
• W2149792725 hasConcept C2776256026 @default.
• W2149792725 hasConcept C2777583451 @default.
• W2149792725 hasConcept C2778087573 @default.
• W2149792725 hasConcept C2778729363 @default.
• W2149792725 hasConcept C2778820342 @default.
• W2149792725 hasConcept C2779438470 @default.
• W2149792725 hasConcept C2780580887 @default.
• W2149792725 hasConcept C42362537 @default.
• W2149792725 hasConcept C502942594 @default.
• W2149792725 hasConcept C54355233 @default.
• W2149792725 hasConcept C55493867 @default.
• W2149792725 hasConcept C71924100 @default.
• W2149792725 hasConcept C86803240 @default.
• W2149792725 hasConcept C98274493 @default.
• W2149792725 hasConceptScore W2149792725C121608353 @default.
• W2149792725 hasConceptScore W2149792725C143998085 @default.
• W2149792725 hasConceptScore W2149792725C170493617 @default.
• W2149792725 hasConceptScore W2149792725C190283241 @default.
• W2149792725 hasConceptScore W2149792725C203522944 @default.
• W2149792725 hasConceptScore W2149792725C2776256026 @default.
• W2149792725 hasConceptScore W2149792725C2777583451 @default.
• W2149792725 hasConceptScore W2149792725C2778087573 @default.
• W2149792725 hasConceptScore W2149792725C2778729363 @default.
• W2149792725 hasConceptScore W2149792725C2778820342 @default.
• W2149792725 hasConceptScore W2149792725C2779438470 @default.
• W2149792725 hasConceptScore W2149792725C2780580887 @default.
• W2149792725 hasConceptScore W2149792725C42362537 @default.
• W2149792725 hasConceptScore W2149792725C502942594 @default.
• W2149792725 hasConceptScore W2149792725C54355233 @default.
• W2149792725 hasConceptScore W2149792725C55493867 @default.
• W2149792725 hasConceptScore W2149792725C71924100 @default.
• W2149792725 hasConceptScore W2149792725C86803240 @default.
• W2149792725 hasConceptScore W2149792725C98274493 @default.
• W2149792725 hasIssue "2" @default.
• W2149792725 hasLocation W21497927251 @default.
• W2149792725 hasLocation W21497927252 @default.
• W2149792725 hasOpenAccess W2149792725 @default.
• W2149792725 hasPrimaryLocation W21497927251 @default.
• W2149792725 hasRelatedWork W1977332018 @default.

• next