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• W2149794013 abstract "Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively)." @default.
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• W2149794013 date "2004-09-01" @default.
• W2149794013 modified "2023-10-14" @default.
• W2149794013 title "Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors" @default.
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• W2149794013 doi "https://doi.org/10.1016/j.bmcl.2004.06.099" @default.
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