FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149794224> ?p ?o ?g. }

• W2149794224 endingPage "3066" @default.
• W2149794224 startingPage "3058" @default.
• W2149794224 abstract "Overexpression of the gene encoding phosphoprotein enriched in astrocytes 15 (PEA15), also known as phosphoprotein enriched in diabetes (PED), causes insulin resistance and diabetes in transgenic mice and has been observed in type 2 diabetic individuals. The aim of this study was to investigate whether PEA15 overexpression occurs in individuals at high risk of diabetes and whether it is associated with specific type 2 diabetes subphenotypes.We analysed PEA15 expression in euglycaemic first-degree relatives (FDR) of type 2 diabetic subjects.The expression of PEA15 in peripheral blood leucocytes (PBLs) paralleled that in fat and skeletal muscle tissues. In PBLs from the FDR, PEA15 expression was two-fold higher than in euglycaemic individuals with no family history of diabetes (control subjects), both at the protein and the mRNA level (p < 0.001). The expression of PEA15 was comparable in FDR and type 2 diabetic subjects and in each group close to one-third of the subjects expressed PEA15 levels more than 2 SD higher than the mean of control subjects. Subjects with IFG with at least one type 2 diabetes-affected FDR also overexpressed PEA15 (p < 0.05). In all the groups analysed, PEA15 expression was independent of sex and unrelated to age, BMI, waist circumference, systolic and diastolic BP, and fasting cholesterol, triacylglycerol and glucose levels. However, in euglycaemic FDR of type 2 diabetic subjects, PEA15 expression was inversely correlated with insulin sensitivity (r = -557, p = 0.01).We conclude that PEA15 overexpression represents a common defect in FDR of patients with type 2 diabetes and is correlated with reduced insulin sensitivity in these individuals." @default.
• W2149794224 created "2016-06-24" @default.
• W2149794224 creator A5001056979 @default.
• W2149794224 creator A5010906352 @default.
• W2149794224 creator A5014399871 @default.
• W2149794224 creator A5020383232 @default.
• W2149794224 creator A5024811698 @default.
• W2149794224 creator A5028448449 @default.
• W2149794224 creator A5039742442 @default.
• W2149794224 creator A5041306496 @default.
• W2149794224 creator A5052295592 @default.
• W2149794224 creator A5055296682 @default.
• W2149794224 creator A5059323960 @default.
• W2149794224 creator A5080212539 @default.
• W2149794224 creator A5083376443 @default.
• W2149794224 creator A5084623347 @default.
• W2149794224 creator A5084810600 @default.
• W2149794224 creator A5086146217 @default.
• W2149794224 date "2006-10-05" @default.
• W2149794224 modified "2023-10-18" @default.
• W2149794224 title "The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes" @default.
• W2149794224 cites W1507379897 @default.
• W2149794224 cites W1967637444 @default.
• W2149794224 cites W1969294711 @default.
• W2149794224 cites W1970384979 @default.
• W2149794224 cites W1971110766 @default.
• W2149794224 cites W1977371761 @default.
• W2149794224 cites W1988456343 @default.
• W2149794224 cites W2002924560 @default.
• W2149794224 cites W2014382148 @default.
• W2149794224 cites W2026900959 @default.
• W2149794224 cites W2050841260 @default.
• W2149794224 cites W2060211780 @default.
• W2149794224 cites W2074313102 @default.
• W2149794224 cites W2083531457 @default.
• W2149794224 cites W2085073265 @default.
• W2149794224 cites W2087541538 @default.
• W2149794224 cites W2091764130 @default.
• W2149794224 cites W2100837269 @default.
• W2149794224 cites W2108890805 @default.
• W2149794224 cites W2113356346 @default.
• W2149794224 cites W2116654405 @default.
• W2149794224 cites W2121790250 @default.
• W2149794224 cites W2123106337 @default.
• W2149794224 cites W2130410032 @default.
• W2149794224 cites W2136638001 @default.
• W2149794224 cites W2138012930 @default.
• W2149794224 cites W2150981747 @default.
• W2149794224 cites W2154969812 @default.
• W2149794224 cites W2155679733 @default.
• W2149794224 cites W2158617540 @default.
• W2149794224 cites W2160234571 @default.
• W2149794224 cites W2164200714 @default.
• W2149794224 cites W2164920328 @default.
• W2149794224 cites W2330505590 @default.
• W2149794224 doi "https://doi.org/10.1007/s00125-006-0455-5" @default.
• W2149794224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17021921" @default.
• W2149794224 hasPublicationYear "2006" @default.
• W2149794224 type Work @default.
• W2149794224 sameAs 2149794224 @default.
• W2149794224 citedByCount "45" @default.
• W2149794224 countsByYear W21497942242012 @default.
• W2149794224 countsByYear W21497942242013 @default.
• W2149794224 countsByYear W21497942242014 @default.
• W2149794224 countsByYear W21497942242015 @default.
• W2149794224 countsByYear W21497942242016 @default.
• W2149794224 countsByYear W21497942242017 @default.
• W2149794224 countsByYear W21497942242019 @default.
• W2149794224 countsByYear W21497942242020 @default.
• W2149794224 countsByYear W21497942242021 @default.
• W2149794224 countsByYear W21497942242023 @default.
• W2149794224 crossrefType "journal-article" @default.
• W2149794224 hasAuthorship W2149794224A5001056979 @default.
• W2149794224 hasAuthorship W2149794224A5010906352 @default.
• W2149794224 hasAuthorship W2149794224A5014399871 @default.
• W2149794224 hasAuthorship W2149794224A5020383232 @default.
• W2149794224 hasAuthorship W2149794224A5024811698 @default.
• W2149794224 hasAuthorship W2149794224A5028448449 @default.
• W2149794224 hasAuthorship W2149794224A5039742442 @default.
• W2149794224 hasAuthorship W2149794224A5041306496 @default.
• W2149794224 hasAuthorship W2149794224A5052295592 @default.
• W2149794224 hasAuthorship W2149794224A5055296682 @default.
• W2149794224 hasAuthorship W2149794224A5059323960 @default.
• W2149794224 hasAuthorship W2149794224A5080212539 @default.
• W2149794224 hasAuthorship W2149794224A5083376443 @default.
• W2149794224 hasAuthorship W2149794224A5084623347 @default.
• W2149794224 hasAuthorship W2149794224A5084810600 @default.
• W2149794224 hasAuthorship W2149794224A5086146217 @default.
• W2149794224 hasBestOaLocation W21497942241 @default.
• W2149794224 hasConcept C104317684 @default.
• W2149794224 hasConcept C126322002 @default.
• W2149794224 hasConcept C134018914 @default.
• W2149794224 hasConcept C2777061661 @default.
• W2149794224 hasConcept C2777180221 @default.
• W2149794224 hasConcept C2777391703 @default.
• W2149794224 hasConcept C2779862289 @default.
• W2149794224 hasConcept C2781179581 @default.
• W2149794224 hasConcept C54355233 @default.

• next