FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149798506> ?p ?o ?g. }

• W2149798506 endingPage "1995" @default.
• W2149798506 startingPage "1987" @default.
• W2149798506 abstract "Abstract Objective —To assess the in vitro effects of various nalbuphine concentrations on viability and wound healing ability of corneal cells and potential drug transport through the corneal epithelium. Sample —Cultured canine and human corneal epithelial cells (CECs) and cultured canine corneal stromal fibroblasts. Procedures —CECs and stromal fibroblasts were exposed to nalbuphine (concentration of solutions ranged from 0% to 1.2%) for up to 30 minutes, and viability was assessed with a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A standard scratch test technique was used. Wound healing of CECs and stromal fibroblasts was evaluated following treatment with nalbuphine solutions < 0.1%. Liquid chromatography–mass spectrometry–mass spectrometry analysis was used to evaluate drug transport across a monolayer and a multilayer of human CECs. Results —A progressive decrease in viability was detected in canine CECs for all nalbuphine treatment groups, whereas treatment with only 0.5% or 1.2% nalbuphine significantly reduced corneal stromal fibroblast viability, compared with results for control cells. Within 24 hours, treatment with 0.1% nalbuphine solution significantly altered the healing rate of both canine CECs and stromal fibroblasts. Continuous increases in transport rates of nalbuphine were detected with time for both the monolayer and multilayer of human CECs. Conclusions and Clinical Relevance —In vitro, nalbuphine potentially could penetrate through corneal tissue, but it may cause damage to the corneal epithelium and stromal fibroblasts. Therefore, nalbuphine potentially may impair corneal wound healing." @default.
• W2149798506 created "2016-06-24" @default.
• W2149798506 creator A5016566452 @default.
• W2149798506 creator A5050741653 @default.
• W2149798506 creator A5063469014 @default.
• W2149798506 creator A5069229911 @default.
• W2149798506 creator A5083306679 @default.
• W2149798506 creator A5088601998 @default.
• W2149798506 date "2012-12-01" @default.
• W2149798506 modified "2023-10-16" @default.
• W2149798506 title "Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells" @default.
• W2149798506 cites W1504134930 @default.
• W2149798506 cites W1517949328 @default.
• W2149798506 cites W1982265488 @default.
• W2149798506 cites W1983312503 @default.
• W2149798506 cites W1988739116 @default.
• W2149798506 cites W1993136139 @default.
• W2149798506 cites W1993344156 @default.
• W2149798506 cites W1998860801 @default.
• W2149798506 cites W2007666439 @default.
• W2149798506 cites W2007755987 @default.
• W2149798506 cites W2009349449 @default.
• W2149798506 cites W2018473393 @default.
• W2149798506 cites W2023903257 @default.
• W2149798506 cites W2040016239 @default.
• W2149798506 cites W2042343633 @default.
• W2149798506 cites W2043548678 @default.
• W2149798506 cites W2059426569 @default.
• W2149798506 cites W2074208432 @default.
• W2149798506 cites W2076869383 @default.
• W2149798506 cites W2077232090 @default.
• W2149798506 cites W2085582905 @default.
• W2149798506 cites W2087900496 @default.
• W2149798506 cites W2093570418 @default.
• W2149798506 cites W2094098598 @default.
• W2149798506 cites W2098693588 @default.
• W2149798506 cites W2126170422 @default.
• W2149798506 cites W2132958631 @default.
• W2149798506 cites W2145463304 @default.
• W2149798506 cites W2163142962 @default.
• W2149798506 cites W2169813687 @default.
• W2149798506 cites W2416135791 @default.
• W2149798506 cites W33995418 @default.
• W2149798506 cites W4205736809 @default.
• W2149798506 doi "https://doi.org/10.2460/ajvr.73.12.1987" @default.
• W2149798506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23176428" @default.
• W2149798506 hasPublicationYear "2012" @default.
• W2149798506 type Work @default.
• W2149798506 sameAs 2149798506 @default.
• W2149798506 citedByCount "1" @default.
• W2149798506 countsByYear W21497985062020 @default.
• W2149798506 crossrefType "journal-article" @default.
• W2149798506 hasAuthorship W2149798506A5016566452 @default.
• W2149798506 hasAuthorship W2149798506A5050741653 @default.
• W2149798506 hasAuthorship W2149798506A5063469014 @default.
• W2149798506 hasAuthorship W2149798506A5069229911 @default.
• W2149798506 hasAuthorship W2149798506A5083306679 @default.
• W2149798506 hasAuthorship W2149798506A5088601998 @default.
• W2149798506 hasConcept C118487528 @default.
• W2149798506 hasConcept C142724271 @default.
• W2149798506 hasConcept C16685009 @default.
• W2149798506 hasConcept C16930146 @default.
• W2149798506 hasConcept C170493617 @default.
• W2149798506 hasConcept C185592680 @default.
• W2149798506 hasConcept C202751555 @default.
• W2149798506 hasConcept C203014093 @default.
• W2149798506 hasConcept C2776882836 @default.
• W2149798506 hasConcept C2778977083 @default.
• W2149798506 hasConcept C2779257441 @default.
• W2149798506 hasConcept C2780269544 @default.
• W2149798506 hasConcept C2780381497 @default.
• W2149798506 hasConcept C2781063702 @default.
• W2149798506 hasConcept C53227056 @default.
• W2149798506 hasConcept C55493867 @default.
• W2149798506 hasConcept C71924100 @default.
• W2149798506 hasConcept C98274493 @default.
• W2149798506 hasConceptScore W2149798506C118487528 @default.
• W2149798506 hasConceptScore W2149798506C142724271 @default.
• W2149798506 hasConceptScore W2149798506C16685009 @default.
• W2149798506 hasConceptScore W2149798506C16930146 @default.
• W2149798506 hasConceptScore W2149798506C170493617 @default.
• W2149798506 hasConceptScore W2149798506C185592680 @default.
• W2149798506 hasConceptScore W2149798506C202751555 @default.
• W2149798506 hasConceptScore W2149798506C203014093 @default.
• W2149798506 hasConceptScore W2149798506C2776882836 @default.
• W2149798506 hasConceptScore W2149798506C2778977083 @default.
• W2149798506 hasConceptScore W2149798506C2779257441 @default.
• W2149798506 hasConceptScore W2149798506C2780269544 @default.
• W2149798506 hasConceptScore W2149798506C2780381497 @default.
• W2149798506 hasConceptScore W2149798506C2781063702 @default.
• W2149798506 hasConceptScore W2149798506C53227056 @default.
• W2149798506 hasConceptScore W2149798506C55493867 @default.
• W2149798506 hasConceptScore W2149798506C71924100 @default.
• W2149798506 hasConceptScore W2149798506C98274493 @default.
• W2149798506 hasIssue "12" @default.
• W2149798506 hasLocation W21497985061 @default.
• W2149798506 hasLocation W21497985062 @default.
• W2149798506 hasOpenAccess W2149798506 @default.

• next