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• W2149804105 abstract "Invariant natural killer T (iNKT) cells are a unique population of lipid reactive CD1d restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging innate and adaptive immunity. Diseases ranging from allergy, autoimmunity, and cancer as well as infectious diseases, including viral infection, have been reported to be influenced by iNKT cells. However, it remains unclear how iNKT cells are activated during viral infection, as virus derived lipid antigens have not been reported. Cytokines may activate iNKT cells during infections from influenza and murine cytomegalovirus (MCMV), although CD1d dependent activation is evident in other viral infections. Several viruses, such as dengue virus (DENV), induce CD1d upregulation which correlates with iNKT cell activation. In contrast, Herpes simplex virus type 1 (HSV-1), Human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) and Human papiloma virus (HPV) promote CD1d downregulation as a strategy to evade iNKT cell recognition. These observations suggest the participation of a CD1d-dependent process in the activation of iNKT cells in response to viral infection. Endogenous lipid ligands, including phospholipids as well as glycosphingolipids, such as glucosylceramide have been proposed to mediate iNKT cell activation. Pro-inflammatory signals produced during viral infection may stimulate iNKT cells through enhanced CD1d dependent endogenous lipid presentation. Furthermore, viral infection may alter lipid composition and inhibit endogenous lipid degradation. Recent advances in this field are reviewed." @default.
• W2149804105 created "2016-06-24" @default.
• W2149804105 creator A5001949625 @default.
• W2149804105 creator A5010711716 @default.
• W2149804105 date "2015-07-24" @default.
• W2149804105 modified "2023-10-13" @default.
• W2149804105 title "iNKT Cells and Their Potential Lipid Ligands during Viral Infection" @default.
• W2149804105 cites W1530742573 @default.
• W2149804105 cites W1542749101 @default.
• W2149804105 cites W1580852520 @default.
• W2149804105 cites W1584746705 @default.
• W2149804105 cites W1593022154 @default.
• W2149804105 cites W1748261727 @default.
• W2149804105 cites W1813023762 @default.
• W2149804105 cites W1883217637 @default.
• W2149804105 cites W1973040027 @default.
• W2149804105 cites W1973753059 @default.
• W2149804105 cites W1976212425 @default.
• W2149804105 cites W1976816026 @default.
• W2149804105 cites W1980214977 @default.
• W2149804105 cites W1980575024 @default.
• W2149804105 cites W1980835313 @default.
• W2149804105 cites W1981288085 @default.
• W2149804105 cites W1982720299 @default.
• W2149804105 cites W1987340797 @default.
• W2149804105 cites W1988573003 @default.
• W2149804105 cites W1988932163 @default.
• W2149804105 cites W1991320900 @default.
• W2149804105 cites W1991668266 @default.
• W2149804105 cites W1991722867 @default.
• W2149804105 cites W1992492030 @default.
• W2149804105 cites W1992523113 @default.
• W2149804105 cites W1994397500 @default.
• W2149804105 cites W2002640020 @default.
• W2149804105 cites W2003625969 @default.
• W2149804105 cites W2004851344 @default.
• W2149804105 cites W2007199806 @default.
• W2149804105 cites W2008886674 @default.
• W2149804105 cites W2024436717 @default.
• W2149804105 cites W2026341611 @default.
• W2149804105 cites W2031006767 @default.
• W2149804105 cites W2031579881 @default.
• W2149804105 cites W2037584685 @default.
• W2149804105 cites W2040393349 @default.
• W2149804105 cites W2046085625 @default.
• W2149804105 cites W2046549183 @default.
• W2149804105 cites W2053088462 @default.
• W2149804105 cites W2054094210 @default.
• W2149804105 cites W2057209101 @default.
• W2149804105 cites W2059254962 @default.
• W2149804105 cites W2063874036 @default.
• W2149804105 cites W2064116640 @default.
• W2149804105 cites W2069556438 @default.
• W2149804105 cites W2071288084 @default.
• W2149804105 cites W2072555165 @default.
• W2149804105 cites W2073808197 @default.
• W2149804105 cites W2075364390 @default.
• W2149804105 cites W2076024275 @default.
• W2149804105 cites W2088064337 @default.
• W2149804105 cites W2089940031 @default.
• W2149804105 cites W2099518656 @default.
• W2149804105 cites W2100213157 @default.
• W2149804105 cites W2101773187 @default.
• W2149804105 cites W2102355478 @default.
• W2149804105 cites W2102785691 @default.
• W2149804105 cites W2110045901 @default.
• W2149804105 cites W2118937284 @default.
• W2149804105 cites W2121477549 @default.
• W2149804105 cites W2122130567 @default.
• W2149804105 cites W2122582242 @default.
• W2149804105 cites W2123832762 @default.
• W2149804105 cites W2124491055 @default.
• W2149804105 cites W2126161157 @default.
• W2149804105 cites W2131423211 @default.
• W2149804105 cites W2137075088 @default.
• W2149804105 cites W2137597074 @default.
• W2149804105 cites W2138640344 @default.
• W2149804105 cites W2140991438 @default.
• W2149804105 cites W2148115090 @default.
• W2149804105 cites W2150998778 @default.
• W2149804105 cites W2151123418 @default.
• W2149804105 cites W2151164793 @default.
• W2149804105 cites W2151250349 @default.
• W2149804105 cites W2153416566 @default.
• W2149804105 cites W2156472038 @default.
• W2149804105 cites W2163792696 @default.
• W2149804105 cites W2164486730 @default.
• W2149804105 cites W2164513774 @default.
• W2149804105 cites W2403002701 @default.
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• W2149804105 doi "https://doi.org/10.3389/fimmu.2015.00378" @default.
• W2149804105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4513233" @default.
• W2149804105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26257744" @default.
• W2149804105 hasPublicationYear "2015" @default.
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