FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149810322> ?p ?o ?g. }

• W2149810322 endingPage "729" @default.
• W2149810322 startingPage "719" @default.
• W2149810322 abstract "The RMA-S cell line was derived from the Raucher virus-induced murine cell line RBL-5 by ethylmethane sulfonate mutagenesis and anti-H-2 antibody plus complement selection (Ljunggren, H.-G., and K. Karre. 1985. J. Exp. Med. 162:1745). RMA-S is defective in the ability to present endogenously synthesized antigens to class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) (Townsend, A., C. Ohlen, J. Bastin, H.-G. Ljunggren, L. Foster, and K. Karre. 1989. Nature [Lond.]. 340:443; Ohlen, C., J. Bastin, H.-G. Ljunggren, L. Foster, E. Wolpert, G. Klein, A. R. M. Townsend, and K. Karre. 1990. J. Immunol. 145:52). This defect has been attributed to the inability of RMA-S to deliver antigenic peptides derived from antigens in the cytosol into the endoplasmic reticulum (ER), where they can associate with class I MHC molecules (Townsend, A., C. Ohlen, J. Bastin, H.-G. Ljunggren, L. Foster, and K. Karre. 1989. Nature [Lond.]. 340:443). We show that RMA-S can present at least one endogenous antigen, vesicular stomatitis virus nucleoprotein (VSV-N), to class I MHC-restricted CTL. RMA-S presents VSV-N to CTL both when infected with VSV or transfected with the VSV nucleoprotein gene. The natural antigenic VSV nucleoprotein peptides purified from either RMA or RMA-S are indistinguishable when analyzed by high performance liquid chromatography. We also show that the genetic defect responsible for the RMA-S phenotype maps to the murine chromosome 17. This chromosome encodes the murine class I MHC genes as well as two genes, HAM-1 and -2, with homology to the adenosine triphosphate-dependent transporter superfamily (Monaco, J. J., S. Cho, and M. Attaya. 1990. Science [Wash. DC]. 250:1723). These results suggest that the system that delivers antigenic peptides from the cytosol to the ER in RMA-S may still be present and retain partial function." @default.
• W2149810322 created "2016-06-24" @default.
• W2149810322 creator A5084708531 @default.
• W2149810322 creator A5088675599 @default.
• W2149810322 date "1992-03-01" @default.
• W2149810322 modified "2023-10-06" @default.
• W2149810322 title "An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S." @default.
• W2149810322 cites W1498425435 @default.
• W2149810322 cites W1540216047 @default.
• W2149810322 cites W1550101617 @default.
• W2149810322 cites W1665121191 @default.
• W2149810322 cites W1987752224 @default.
• W2149810322 cites W1994435196 @default.
• W2149810322 cites W2000734326 @default.
• W2149810322 cites W2001852133 @default.
• W2149810322 cites W2006629564 @default.
• W2149810322 cites W2008860475 @default.
• W2149810322 cites W2009115410 @default.
• W2149810322 cites W2031086514 @default.
• W2149810322 cites W2031124741 @default.
• W2149810322 cites W2035891785 @default.
• W2149810322 cites W2042102115 @default.
• W2149810322 cites W2046760991 @default.
• W2149810322 cites W2055034075 @default.
• W2149810322 cites W2055282100 @default.
• W2149810322 cites W2074061180 @default.
• W2149810322 cites W2074360298 @default.
• W2149810322 cites W2074737029 @default.
• W2149810322 cites W2075608929 @default.
• W2149810322 cites W2080757497 @default.
• W2149810322 cites W2082173837 @default.
• W2149810322 cites W2083988731 @default.
• W2149810322 cites W2088513299 @default.
• W2149810322 cites W2096273252 @default.
• W2149810322 cites W2105818762 @default.
• W2149810322 cites W2118376550 @default.
• W2149810322 cites W309166525 @default.
• W2149810322 doi "https://doi.org/10.1084/jem.175.3.719" @default.
• W2149810322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119158" @default.
• W2149810322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1311017" @default.
• W2149810322 hasPublicationYear "1992" @default.
• W2149810322 type Work @default.
• W2149810322 sameAs 2149810322 @default.
• W2149810322 citedByCount "72" @default.
• W2149810322 countsByYear W21498103222013 @default.
• W2149810322 countsByYear W21498103222022 @default.
• W2149810322 crossrefType "journal-article" @default.
• W2149810322 hasAuthorship W2149810322A5084708531 @default.
• W2149810322 hasAuthorship W2149810322A5088675599 @default.
• W2149810322 hasBestOaLocation W21498103221 @default.
• W2149810322 hasConcept C108249834 @default.
• W2149810322 hasConcept C147483822 @default.
• W2149810322 hasConcept C147969180 @default.
• W2149810322 hasConcept C153911025 @default.
• W2149810322 hasConcept C154317977 @default.
• W2149810322 hasConcept C159047783 @default.
• W2149810322 hasConcept C167672396 @default.
• W2149810322 hasConcept C170627219 @default.
• W2149810322 hasConcept C197695756 @default.
• W2149810322 hasConcept C202751555 @default.
• W2149810322 hasConcept C207936829 @default.
• W2149810322 hasConcept C2522874641 @default.
• W2149810322 hasConcept C2779057330 @default.
• W2149810322 hasConcept C54355233 @default.
• W2149810322 hasConcept C60325843 @default.
• W2149810322 hasConcept C83464605 @default.
• W2149810322 hasConcept C86803240 @default.
• W2149810322 hasConceptScore W2149810322C108249834 @default.
• W2149810322 hasConceptScore W2149810322C147483822 @default.
• W2149810322 hasConceptScore W2149810322C147969180 @default.
• W2149810322 hasConceptScore W2149810322C153911025 @default.
• W2149810322 hasConceptScore W2149810322C154317977 @default.
• W2149810322 hasConceptScore W2149810322C159047783 @default.
• W2149810322 hasConceptScore W2149810322C167672396 @default.
• W2149810322 hasConceptScore W2149810322C170627219 @default.
• W2149810322 hasConceptScore W2149810322C197695756 @default.
• W2149810322 hasConceptScore W2149810322C202751555 @default.
• W2149810322 hasConceptScore W2149810322C207936829 @default.
• W2149810322 hasConceptScore W2149810322C2522874641 @default.
• W2149810322 hasConceptScore W2149810322C2779057330 @default.
• W2149810322 hasConceptScore W2149810322C54355233 @default.
• W2149810322 hasConceptScore W2149810322C60325843 @default.
• W2149810322 hasConceptScore W2149810322C83464605 @default.
• W2149810322 hasConceptScore W2149810322C86803240 @default.
• W2149810322 hasIssue "3" @default.
• W2149810322 hasLocation W21498103221 @default.
• W2149810322 hasLocation W21498103222 @default.
• W2149810322 hasLocation W21498103223 @default.
• W2149810322 hasLocation W21498103224 @default.
• W2149810322 hasOpenAccess W2149810322 @default.
• W2149810322 hasPrimaryLocation W21498103221 @default.
• W2149810322 hasRelatedWork W1500975308 @default.
• W2149810322 hasRelatedWork W2003656264 @default.
• W2149810322 hasRelatedWork W2020750867 @default.
• W2149810322 hasRelatedWork W2035413603 @default.
• W2149810322 hasRelatedWork W2075966704 @default.
• W2149810322 hasRelatedWork W2143746835 @default.
• W2149810322 hasRelatedWork W2166054127 @default.

• next