FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149812187> ?p ?o ?g. }

• W2149812187 endingPage "S136" @default.
• W2149812187 startingPage "S135" @default.
• W2149812187 abstract "ObjectiveTo determine the frequency of aneuploidy in preimplantational embryos derived from advanced maternal age (AMA), recurrent pregnancy loss (RPL), spontaneous abortion (SAB) and patient request (RQ) according to the day of embryo biopsy.DesignMulticenter observational study.Materials and MethodsEmbryo biopsies on day 3 or day 5 were referred from fertility centers to the same PGD laboratory. The frequency of aneuploidy in embryos was analyzed according to the patient reason to perform array CGH test. AMA patients were ≥38 years old. Only patients≤35 years old (young women) were selected for RPL, SAB and RQ patients to avoid the influence of the age on the frequency of aneuploidy.ResultsA total of 1703 IVF/ICSI cycles were selected. Embryo biopsies were done at day 3 (1109 cycles) or day 5 (594 cycles). Average age was higher in AMA patient (40.7±2.1); RPL, SAB and RQ age were similar (32.2±2.8, 31.9±2.7 and 31.7±1.7 years old respectively). On day 3, AMA patient had 18.2% (911/5015) of euploid embryos compared to 43.7% (1158/2649) in young women (P<0.001). Euploidy rates on day 3 were lower for RPL 41.5% (350/841) and SAB 41.5% (248/597) groups compared to RQ patients 46.2% (560/1211) (P<0.05). On day 5, AMA patients had lower incidence of euploidy 33.5% (457/1363) than young women 66.7% (663/993) (P<0.001). The euploidy frequency on day 5 for RPL patients (61.1%, 151/247) was significantly lower compared to that for SAB 68.7% (154/224) and RQ 68.6% (358/522) patients (P<0.05).ConclusionThe frequency of aneuploidy is higher in day 3 than day 5 embryos, indicating some incomplete negative selection of aneuploidy embryos through extended culture. The incidence of aneuploidy embryos in patients older than 38 years old is two folds higher than in young women. Also increased was the incidence of aneuploidy in women younger than 35 years old with the indication of RPL. ObjectiveTo determine the frequency of aneuploidy in preimplantational embryos derived from advanced maternal age (AMA), recurrent pregnancy loss (RPL), spontaneous abortion (SAB) and patient request (RQ) according to the day of embryo biopsy. To determine the frequency of aneuploidy in preimplantational embryos derived from advanced maternal age (AMA), recurrent pregnancy loss (RPL), spontaneous abortion (SAB) and patient request (RQ) according to the day of embryo biopsy. DesignMulticenter observational study. Multicenter observational study. Materials and MethodsEmbryo biopsies on day 3 or day 5 were referred from fertility centers to the same PGD laboratory. The frequency of aneuploidy in embryos was analyzed according to the patient reason to perform array CGH test. AMA patients were ≥38 years old. Only patients≤35 years old (young women) were selected for RPL, SAB and RQ patients to avoid the influence of the age on the frequency of aneuploidy. Embryo biopsies on day 3 or day 5 were referred from fertility centers to the same PGD laboratory. The frequency of aneuploidy in embryos was analyzed according to the patient reason to perform array CGH test. AMA patients were ≥38 years old. Only patients≤35 years old (young women) were selected for RPL, SAB and RQ patients to avoid the influence of the age on the frequency of aneuploidy. ResultsA total of 1703 IVF/ICSI cycles were selected. Embryo biopsies were done at day 3 (1109 cycles) or day 5 (594 cycles). Average age was higher in AMA patient (40.7±2.1); RPL, SAB and RQ age were similar (32.2±2.8, 31.9±2.7 and 31.7±1.7 years old respectively). On day 3, AMA patient had 18.2% (911/5015) of euploid embryos compared to 43.7% (1158/2649) in young women (P<0.001). Euploidy rates on day 3 were lower for RPL 41.5% (350/841) and SAB 41.5% (248/597) groups compared to RQ patients 46.2% (560/1211) (P<0.05). On day 5, AMA patients had lower incidence of euploidy 33.5% (457/1363) than young women 66.7% (663/993) (P<0.001). The euploidy frequency on day 5 for RPL patients (61.1%, 151/247) was significantly lower compared to that for SAB 68.7% (154/224) and RQ 68.6% (358/522) patients (P<0.05). A total of 1703 IVF/ICSI cycles were selected. Embryo biopsies were done at day 3 (1109 cycles) or day 5 (594 cycles). Average age was higher in AMA patient (40.7±2.1); RPL, SAB and RQ age were similar (32.2±2.8, 31.9±2.7 and 31.7±1.7 years old respectively). On day 3, AMA patient had 18.2% (911/5015) of euploid embryos compared to 43.7% (1158/2649) in young women (P<0.001). Euploidy rates on day 3 were lower for RPL 41.5% (350/841) and SAB 41.5% (248/597) groups compared to RQ patients 46.2% (560/1211) (P<0.05). On day 5, AMA patients had lower incidence of euploidy 33.5% (457/1363) than young women 66.7% (663/993) (P<0.001). The euploidy frequency on day 5 for RPL patients (61.1%, 151/247) was significantly lower compared to that for SAB 68.7% (154/224) and RQ 68.6% (358/522) patients (P<0.05). ConclusionThe frequency of aneuploidy is higher in day 3 than day 5 embryos, indicating some incomplete negative selection of aneuploidy embryos through extended culture. The incidence of aneuploidy embryos in patients older than 38 years old is two folds higher than in young women. Also increased was the incidence of aneuploidy in women younger than 35 years old with the indication of RPL. The frequency of aneuploidy is higher in day 3 than day 5 embryos, indicating some incomplete negative selection of aneuploidy embryos through extended culture. The incidence of aneuploidy embryos in patients older than 38 years old is two folds higher than in young women. Also increased was the incidence of aneuploidy in women younger than 35 years old with the indication of RPL." @default.
• W2149812187 created "2016-06-24" @default.
• W2149812187 creator A5002953773 @default.
• W2149812187 creator A5014129574 @default.
• W2149812187 creator A5028884962 @default.
• W2149812187 creator A5034590945 @default.
• W2149812187 creator A5039609879 @default.
• W2149812187 creator A5076408535 @default.
• W2149812187 date "2012-09-01" @default.
• W2149812187 modified "2023-09-27" @default.
• W2149812187 title "Incidence of aneuploidy is increased in patients with advanced maternal age and recurrent pregnancy loss" @default.
• W2149812187 doi "https://doi.org/10.1016/j.fertnstert.2012.07.500" @default.
• W2149812187 hasPublicationYear "2012" @default.
• W2149812187 type Work @default.
• W2149812187 sameAs 2149812187 @default.
• W2149812187 citedByCount "0" @default.
• W2149812187 crossrefType "journal-article" @default.
• W2149812187 hasAuthorship W2149812187A5002953773 @default.
• W2149812187 hasAuthorship W2149812187A5014129574 @default.
• W2149812187 hasAuthorship W2149812187A5028884962 @default.
• W2149812187 hasAuthorship W2149812187A5034590945 @default.
• W2149812187 hasAuthorship W2149812187A5039609879 @default.
• W2149812187 hasAuthorship W2149812187A5076408535 @default.
• W2149812187 hasBestOaLocation W21498121871 @default.
• W2149812187 hasConcept C104317684 @default.
• W2149812187 hasConcept C120665830 @default.
• W2149812187 hasConcept C121332964 @default.
• W2149812187 hasConcept C126322002 @default.
• W2149812187 hasConcept C131872663 @default.
• W2149812187 hasConcept C172680121 @default.
• W2149812187 hasConcept C2775934546 @default.
• W2149812187 hasConcept C2776352029 @default.
• W2149812187 hasConcept C2778642596 @default.
• W2149812187 hasConcept C2779234561 @default.
• W2149812187 hasConcept C2779672484 @default.
• W2149812187 hasConcept C29456083 @default.
• W2149812187 hasConcept C30481170 @default.
• W2149812187 hasConcept C54355233 @default.
• W2149812187 hasConcept C55493867 @default.
• W2149812187 hasConcept C61511704 @default.
• W2149812187 hasConcept C71924100 @default.
• W2149812187 hasConcept C86803240 @default.
• W2149812187 hasConceptScore W2149812187C104317684 @default.
• W2149812187 hasConceptScore W2149812187C120665830 @default.
• W2149812187 hasConceptScore W2149812187C121332964 @default.
• W2149812187 hasConceptScore W2149812187C126322002 @default.
• W2149812187 hasConceptScore W2149812187C131872663 @default.
• W2149812187 hasConceptScore W2149812187C172680121 @default.
• W2149812187 hasConceptScore W2149812187C2775934546 @default.
• W2149812187 hasConceptScore W2149812187C2776352029 @default.
• W2149812187 hasConceptScore W2149812187C2778642596 @default.
• W2149812187 hasConceptScore W2149812187C2779234561 @default.
• W2149812187 hasConceptScore W2149812187C2779672484 @default.
• W2149812187 hasConceptScore W2149812187C29456083 @default.
• W2149812187 hasConceptScore W2149812187C30481170 @default.
• W2149812187 hasConceptScore W2149812187C54355233 @default.
• W2149812187 hasConceptScore W2149812187C55493867 @default.
• W2149812187 hasConceptScore W2149812187C61511704 @default.
• W2149812187 hasConceptScore W2149812187C71924100 @default.
• W2149812187 hasConceptScore W2149812187C86803240 @default.
• W2149812187 hasIssue "3" @default.
• W2149812187 hasLocation W21498121871 @default.
• W2149812187 hasOpenAccess W2149812187 @default.
• W2149812187 hasPrimaryLocation W21498121871 @default.
• W2149812187 hasRelatedWork W2017194889 @default.
• W2149812187 hasRelatedWork W2046842812 @default.
• W2149812187 hasRelatedWork W2083397905 @default.
• W2149812187 hasRelatedWork W2135469464 @default.
• W2149812187 hasRelatedWork W2371373004 @default.
• W2149812187 hasRelatedWork W2401739700 @default.
• W2149812187 hasRelatedWork W2404744075 @default.
• W2149812187 hasRelatedWork W2425622575 @default.
• W2149812187 hasRelatedWork W2502977617 @default.
• W2149812187 hasRelatedWork W4302337340 @default.
• W2149812187 hasVolume "98" @default.
• W2149812187 isParatext "false" @default.
• W2149812187 isRetracted "false" @default.
• W2149812187 magId "2149812187" @default.
• W2149812187 workType "article" @default.