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• W2149814701 abstract "Extensive genomic and gene expression studies have been performed in gliomas, but the epigenetic alterations that characterize different subtypes of gliomas remain largely unknown. Here, we analyzed the methylation patterns of 807 genes (1536 CpGs) in a series of 33 low-grade gliomas (LGGs), 36 glioblastomas (GBMs), 8 paired initial and recurrent gliomas, and 9 controls. This analysis was performed with Illumina's Golden Gate Bead methylation arrays and was correlated with clinical, histological, genomic, gene expression, and genotyping data, including IDH1 mutations. Unsupervised hierarchical clustering resulted in 2 groups of gliomas: a group corresponding to de novo GBMs and a group consisting of LGGs, recurrent anaplastic gliomas, and secondary GBMs. When compared with de novo GBMs and controls, this latter group was characterized by a very high frequency of IDH1 mutations and by a hypermethylated profile similar to the recently described glioma CpG island methylator phenotype. MGMT methylation was more frequent in this group. Among the LGG cluster, 1p19q codeleted LGG displayed a distinct methylation profile. A study of paired initial and recurrent gliomas demonstrated that methylation profiles were remarkably stable across glioma evolution, even during anaplastic transformation, suggesting that epigenetic alterations occur early during gliomagenesis. Using the Cancer Genome Atlas data set, we demonstrated that GBM samples that had an LGG-like hypermethylated profile had a high rate of IDH1 mutations and a better outcome. Finally, we identified several hypermethylated and downregulated genes that may be associated with LGG and GBM oncogenesis, LGG oncogenesis, 1p19q codeleted LGG oncogenesis, and GBM oncogenesis." @default.
• W2149814701 created "2016-06-24" @default.
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• W2149814701 date "2010-10-05" @default.
• W2149814701 modified "2023-10-16" @default.
• W2149814701 title "Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis" @default.
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• W2149814701 doi "https://doi.org/10.1093/neuonc/noq110" @default.
• W2149814701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3018904" @default.
• W2149814701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20926426" @default.
• W2149814701 hasPublicationYear "2010" @default.
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