FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149843625> ?p ?o ?g. }

• W2149843625 abstract "Expression of the A and B forms of progesterone receptor (PR) in an appropriate ratio is critical for mammary development. Mammary glands of PR-A transgenic mice, carrying an additional A form of PR as a transgene, exhibit morphological features associated with the development of mammary tumors. Our objective was to determine the roles of estrogen (E) and progesterone (P) in the genesis of mammary hyperplasias/preneoplasias in PR-A transgenics.We subjected PR-A mice to hormonal treatments and analyzed mammary glands for the presence of hyperplasias and used BrdU incorporation to measure proliferation. Quantitative image analysis was carried out to compare levels of latency-associated peptide and transforming growth factor beta 1 (TGFbeta1) between PR-A and PR-B transgenics. Basement membrane disruption was examined by immunofluorescence and proteolytic activity by zymography.The hyperplastic phenotype of PR-A transgenics is inhibited by ovariectomy, and is reversed by treatment with E + P. Studies using the antiestrogen ICI 182,780 or antiprogestins RU486 or ZK 98,299 show that the increase in proliferation requires signaling through E/estrogen receptor alpha but is not sufficient to give rise to hyperplasias, whereas signaling through P/PR has little impact on proliferation but is essential for the manifestation of hyperplasias. Increased proliferation is correlated with decreased TGFbeta1 activation in the PR-A transgenics. Analysis of basement membrane integrity showed loss of laminin-5, collagen III and collagen IV in mammary glands of PR-A mice, which is restored by ovariectomy. Examination of matrix metalloproteases (MMPs) showed that total levels of MMP-2 correlate with the steady-state levels of PR, and that areas of laminin-5 loss coincide with those of activation of MMP-2 in PR-A transgenics. Activation of MMP-2 is dependent on treatment with E and P in ovariectomized wild-type mice, but is achieved only by treatment with P in PR-A mice.These data establish a link between hormonal response, proliferation, modulation of MMP activity and maintenance of basement membrane integrity that depend on a balance in the expression levels of PR-A and PR-B isoforms. Notably, concomitant increased proliferation, due to inhibition of TGFbeta1 activation, and loss of basement membrane integrity, via increased MMP-2 activity, appear to be prerequisites for the PR-A hyperplastic phenotype." @default.
• W2149843625 created "2016-06-24" @default.
• W2149843625 creator A5057610930 @default.
• W2149843625 creator A5062551209 @default.
• W2149843625 creator A5072917052 @default.
• W2149843625 creator A5083389563 @default.
• W2149843625 date "2009-09-29" @default.
• W2149843625 modified "2023-10-18" @default.
• W2149843625 title "Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice" @default.
• W2149843625 cites W1506807751 @default.
• W2149843625 cites W1508838109 @default.
• W2149843625 cites W1605046409 @default.
• W2149843625 cites W1839438061 @default.
• W2149843625 cites W1902824914 @default.
• W2149843625 cites W1922735013 @default.
• W2149843625 cites W1939368710 @default.
• W2149843625 cites W1965768287 @default.
• W2149843625 cites W1996187477 @default.
• W2149843625 cites W1997522367 @default.
• W2149843625 cites W2012904520 @default.
• W2149843625 cites W2016538599 @default.
• W2149843625 cites W2019380047 @default.
• W2149843625 cites W2022030433 @default.
• W2149843625 cites W2022654115 @default.
• W2149843625 cites W2027892036 @default.
• W2149843625 cites W2030899358 @default.
• W2149843625 cites W2061176458 @default.
• W2149843625 cites W2071590828 @default.
• W2149843625 cites W2082559087 @default.
• W2149843625 cites W2096353669 @default.
• W2149843625 cites W2121513486 @default.
• W2149843625 cites W2128840922 @default.
• W2149843625 cites W2144543493 @default.
• W2149843625 cites W2153188915 @default.
• W2149843625 cites W2154568166 @default.
• W2149843625 cites W2159110682 @default.
• W2149843625 cites W2166673284 @default.
• W2149843625 cites W2168115520 @default.
• W2149843625 cites W2172256092 @default.
• W2149843625 cites W2754865425 @default.
• W2149843625 doi "https://doi.org/10.1186/bcr2408" @default.
• W2149843625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2790852" @default.
• W2149843625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19788752" @default.
• W2149843625 hasPublicationYear "2009" @default.
• W2149843625 type Work @default.
• W2149843625 sameAs 2149843625 @default.
• W2149843625 citedByCount "14" @default.
• W2149843625 countsByYear W21498436252012 @default.
• W2149843625 countsByYear W21498436252013 @default.
• W2149843625 countsByYear W21498436252016 @default.
• W2149843625 countsByYear W21498436252018 @default.
• W2149843625 countsByYear W21498436252020 @default.
• W2149843625 countsByYear W21498436252021 @default.
• W2149843625 countsByYear W21498436252022 @default.
• W2149843625 crossrefType "journal-article" @default.
• W2149843625 hasAuthorship W2149843625A5057610930 @default.
• W2149843625 hasAuthorship W2149843625A5062551209 @default.
• W2149843625 hasAuthorship W2149843625A5072917052 @default.
• W2149843625 hasAuthorship W2149843625A5083389563 @default.
• W2149843625 hasBestOaLocation W21498436251 @default.
• W2149843625 hasConcept C102230213 @default.
• W2149843625 hasConcept C104317684 @default.
• W2149843625 hasConcept C109523444 @default.
• W2149843625 hasConcept C121608353 @default.
• W2149843625 hasConcept C126322002 @default.
• W2149843625 hasConcept C134018914 @default.
• W2149843625 hasConcept C170493617 @default.
• W2149843625 hasConcept C177430391 @default.
• W2149843625 hasConcept C189165786 @default.
• W2149843625 hasConcept C2776067312 @default.
• W2149843625 hasConcept C2776193487 @default.
• W2149843625 hasConcept C2777164284 @default.
• W2149843625 hasConcept C2778001805 @default.
• W2149843625 hasConcept C2779814568 @default.
• W2149843625 hasConcept C530470458 @default.
• W2149843625 hasConcept C55493867 @default.
• W2149843625 hasConcept C71924100 @default.
• W2149843625 hasConcept C84606932 @default.
• W2149843625 hasConcept C86803240 @default.
• W2149843625 hasConcept C95444343 @default.
• W2149843625 hasConcept C98717036 @default.
• W2149843625 hasConceptScore W2149843625C102230213 @default.
• W2149843625 hasConceptScore W2149843625C104317684 @default.
• W2149843625 hasConceptScore W2149843625C109523444 @default.
• W2149843625 hasConceptScore W2149843625C121608353 @default.
• W2149843625 hasConceptScore W2149843625C126322002 @default.
• W2149843625 hasConceptScore W2149843625C134018914 @default.
• W2149843625 hasConceptScore W2149843625C170493617 @default.
• W2149843625 hasConceptScore W2149843625C177430391 @default.
• W2149843625 hasConceptScore W2149843625C189165786 @default.
• W2149843625 hasConceptScore W2149843625C2776067312 @default.
• W2149843625 hasConceptScore W2149843625C2776193487 @default.
• W2149843625 hasConceptScore W2149843625C2777164284 @default.
• W2149843625 hasConceptScore W2149843625C2778001805 @default.
• W2149843625 hasConceptScore W2149843625C2779814568 @default.
• W2149843625 hasConceptScore W2149843625C530470458 @default.
• W2149843625 hasConceptScore W2149843625C55493867 @default.
• W2149843625 hasConceptScore W2149843625C71924100 @default.
• W2149843625 hasConceptScore W2149843625C84606932 @default.
• W2149843625 hasConceptScore W2149843625C86803240 @default.

• next