FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149860604> ?p ?o ?g. }

• W2149860604 abstract "Fluoroquinolones are sometimes used to treat multiple-drug-resistant and drug-sensitive tuberculosis. The effects of fluoroquinolones in tuberculosis regimens need to be assessed.To assess fluoroquinolones as additional or substitute components to antituberculous drug regimens for drug-sensitive and drug-resistant tuberculosis.We searched the Cochrane Infectious Diseases Group Specialized Register (April 2005), CENTRAL (The Cochrane Library Issue 1, 2005), MEDLINE (1966 to April 2005), EMBASE (1974 to April 2005), LILACS (1982 to April 2005), Science Citation Index (1940 to April 2005), and Russian database (1988 to April 2005). We also scanned reference lists of all identified studies and contacted researchers.Randomized controlled trials of antituberculous regimens containing fluoroquinolones in people diagnosed with bacteriologically positive (sputum smear or culture) pulmonary tuberculosis.Two authors independently applied inclusion criteria, assessed methodological quality, and extracted data. We used relative risk (RR) for dichotomous data, weighted mean difference (WMD) for continuous data (both with 95% confidence intervals (CI)), and the random-effects model if we detected heterogeneity and appropriate to combine data.Ten trials (1178 participants) met the inclusion criteria. No statistically significant difference was found in trials substituting ciprofloxacin or ofloxacin for first-line drugs in relation to cure (89 participants, 2 trials), treatment failure (388 participants, 3 trials), or clinical or radiological improvement (216 participants, 2 trials). Substituting ciprofloxacin into first-line regimens in drug-sensitive tuberculosis led to a higher incidence of relapse (RR 7.17, 95% CI 1.33 to 38.58; 384 participants, 3 trials) and longer time to sputum culture conversion (WMD 0.50 months, 95% CI 0.18 to 0.82; 168 participants, 1 trial), although this was confined to HIV-positive participants. Adding or substituting levofloxacin to basic regimens in drug-resistant areas had no effect. A comparison of sparfloxacin versus ofloxacin added to regimens showed no statistically significant difference in cure (184 participants, 2 trials), treatment failure (149 participants, 2 trials), or total number of adverse events (253 participants, 3 trials).Only ciprofloxacin, ofloxacin, levofloxacin, and sparfloxacin have been tested in randomized controlled trials for treating tuberculosis. We cannot recommend ciprofloxacin in treating tuberculosis. Trials of newer fluoroquinolones for treating tuberculosis are needed. No difference has been demonstrated between sparfloxacin and ofloxacin in drug-resistant tuberculosis." @default.
• W2149860604 created "2016-06-24" @default.
• W2149860604 creator A5013868193 @default.
• W2149860604 creator A5019520387 @default.
• W2149860604 creator A5023828847 @default.
• W2149860604 date "2005-07-20" @default.
• W2149860604 modified "2023-10-10" @default.
• W2149860604 title "Fluoroquinolones for treating tuberculosis" @default.
• W2149860604 cites W1966126698 @default.
• W2149860604 cites W1966820980 @default.
• W2149860604 cites W1967748659 @default.
• W2149860604 cites W1986822335 @default.
• W2149860604 cites W1996896990 @default.
• W2149860604 cites W1996930122 @default.
• W2149860604 cites W2000452767 @default.
• W2149860604 cites W2013369772 @default.
• W2149860604 cites W2019023077 @default.
• W2149860604 cites W2032342750 @default.
• W2149860604 cites W2032353669 @default.
• W2149860604 cites W2033890227 @default.
• W2149860604 cites W2045865641 @default.
• W2149860604 cites W2047505716 @default.
• W2149860604 cites W2047606924 @default.
• W2149860604 cites W2061088592 @default.
• W2149860604 cites W2065376976 @default.
• W2149860604 cites W2070043025 @default.
• W2149860604 cites W2079152792 @default.
• W2149860604 cites W2082004384 @default.
• W2149860604 cites W2095037435 @default.
• W2149860604 cites W2095544141 @default.
• W2149860604 cites W2102212813 @default.
• W2149860604 cites W2106949433 @default.
• W2149860604 cites W2118660489 @default.
• W2149860604 cites W2144010669 @default.
• W2149860604 cites W2147445933 @default.
• W2149860604 cites W2153938082 @default.
• W2149860604 cites W2155336089 @default.
• W2149860604 cites W2159470927 @default.
• W2149860604 cites W2162098313 @default.
• W2149860604 cites W2418210342 @default.
• W2149860604 cites W4232723310 @default.
• W2149860604 cites W4238748109 @default.
• W2149860604 doi "https://doi.org/10.1002/14651858.cd004795.pub2" @default.
• W2149860604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18254061" @default.
• W2149860604 hasPublicationYear "2005" @default.
• W2149860604 type Work @default.
• W2149860604 sameAs 2149860604 @default.
• W2149860604 citedByCount "34" @default.
• W2149860604 countsByYear W21498606042012 @default.
• W2149860604 countsByYear W21498606042013 @default.
• W2149860604 countsByYear W21498606042014 @default.
• W2149860604 countsByYear W21498606042015 @default.
• W2149860604 countsByYear W21498606042016 @default.
• W2149860604 countsByYear W21498606042017 @default.
• W2149860604 countsByYear W21498606042018 @default.
• W2149860604 crossrefType "reference-entry" @default.
• W2149860604 hasAuthorship W2149860604A5013868193 @default.
• W2149860604 hasAuthorship W2149860604A5019520387 @default.
• W2149860604 hasAuthorship W2149860604A5023828847 @default.
• W2149860604 hasConcept C126322002 @default.
• W2149860604 hasConcept C142724271 @default.
• W2149860604 hasConcept C17744445 @default.
• W2149860604 hasConcept C199539241 @default.
• W2149860604 hasConcept C204787440 @default.
• W2149860604 hasConcept C27081682 @default.
• W2149860604 hasConcept C2776301714 @default.
• W2149860604 hasConcept C2776478404 @default.
• W2149860604 hasConcept C2777768864 @default.
• W2149860604 hasConcept C2779473830 @default.
• W2149860604 hasConcept C2781069245 @default.
• W2149860604 hasConcept C44249647 @default.
• W2149860604 hasConcept C535046627 @default.
• W2149860604 hasConcept C71924100 @default.
• W2149860604 hasConcept C82789193 @default.
• W2149860604 hasConcept C95190672 @default.
• W2149860604 hasConceptScore W2149860604C126322002 @default.
• W2149860604 hasConceptScore W2149860604C142724271 @default.
• W2149860604 hasConceptScore W2149860604C17744445 @default.
• W2149860604 hasConceptScore W2149860604C199539241 @default.
• W2149860604 hasConceptScore W2149860604C204787440 @default.
• W2149860604 hasConceptScore W2149860604C27081682 @default.
• W2149860604 hasConceptScore W2149860604C2776301714 @default.
• W2149860604 hasConceptScore W2149860604C2776478404 @default.
• W2149860604 hasConceptScore W2149860604C2777768864 @default.
• W2149860604 hasConceptScore W2149860604C2779473830 @default.
• W2149860604 hasConceptScore W2149860604C2781069245 @default.
• W2149860604 hasConceptScore W2149860604C44249647 @default.
• W2149860604 hasConceptScore W2149860604C535046627 @default.
• W2149860604 hasConceptScore W2149860604C71924100 @default.
• W2149860604 hasConceptScore W2149860604C82789193 @default.
• W2149860604 hasConceptScore W2149860604C95190672 @default.
• W2149860604 hasLocation W21498606041 @default.
• W2149860604 hasLocation W21498606042 @default.
• W2149860604 hasOpenAccess W2149860604 @default.
• W2149860604 hasPrimaryLocation W21498606041 @default.
• W2149860604 hasRelatedWork W1859326399 @default.
• W2149860604 hasRelatedWork W1981847179 @default.
• W2149860604 hasRelatedWork W2072697776 @default.
• W2149860604 hasRelatedWork W2119656846 @default.
• W2149860604 hasRelatedWork W2134468770 @default.

• next