FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149861331> ?p ?o ?g. }

• W2149861331 endingPage "2992" @default.
• W2149861331 startingPage "2983" @default.
• W2149861331 abstract "Accumulation of cholesteryl esters (CEs) in macrophage foam cells, central to atherosclerotic plaque formation, occurs as a result of imbalance between the cholesterol influx and efflux pathways. While the uptake, or influx, of modified lipoproteins is largely unregulated, extracellular acceptor-mediated free cholesterol (FC) efflux is rate limited by the intracellular hydrolysis of CE. We previously identified and cloned a neutral CE hydrolase (CEH) from human macrophages and demonstrated its role in cellular CE mobilization. In the present study, we examined the hypothesis that macrophage-specific overexpression of CEH in atherosclerosis-susceptible Ldlr(-/-) mice will result in reduction of diet-induced atherosclerosis. Transgenic mice overexpressing this CEH specifically in the macrophages (driven by scavenger receptor promoter/enhancer) were developed and crossed into the Ldlr(-/-) background (Ldlr(-/-)CEHTg mice). Macrophage-specific overexpression of CEH led to a significant reduction in the lesion area and cholesterol content of high-fat, high-cholesterol diet-induced atherosclerotic lesions. The lesions from Ldlr(-/-)CEHTg mice did not have increased FC, were less necrotic, and contained significantly higher numbers of viable macrophage foam cells. Higher CEH-mediated FC efflux resulted in enhanced flux of FC from macrophages to gall bladder bile and feces in vivo. These studies demonstrate that by enhancing cholesterol efflux and reverse cholesterol transport, macrophage-specific overexpression of CEH is antiatherogenic." @default.
• W2149861331 created "2016-06-24" @default.
• W2149861331 creator A5011065536 @default.
• W2149861331 creator A5013965800 @default.
• W2149861331 creator A5021974562 @default.
• W2149861331 creator A5052624003 @default.
• W2149861331 creator A5066294981 @default.
• W2149861331 creator A5073819497 @default.
• W2149861331 date "2007-10-01" @default.
• W2149861331 modified "2023-09-26" @default.
• W2149861331 title "Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr–/– mice" @default.
• W2149861331 cites W1564613206 @default.
• W2149861331 cites W1764819423 @default.
• W2149861331 cites W1775749144 @default.
• W2149861331 cites W1861932357 @default.
• W2149861331 cites W1871478581 @default.
• W2149861331 cites W1940775645 @default.
• W2149861331 cites W1965006422 @default.
• W2149861331 cites W1965161849 @default.
• W2149861331 cites W1977842776 @default.
• W2149861331 cites W1986755882 @default.
• W2149861331 cites W1988657641 @default.
• W2149861331 cites W1993025383 @default.
• W2149861331 cites W1996078764 @default.
• W2149861331 cites W2001295617 @default.
• W2149861331 cites W2023235793 @default.
• W2149861331 cites W2026803652 @default.
• W2149861331 cites W2027976496 @default.
• W2149861331 cites W2030952351 @default.
• W2149861331 cites W2035780860 @default.
• W2149861331 cites W2059775894 @default.
• W2149861331 cites W2061863527 @default.
• W2149861331 cites W2082387556 @default.
• W2149861331 cites W2082918438 @default.
• W2149861331 cites W2085929154 @default.
• W2149861331 cites W2086831301 @default.
• W2149861331 cites W2105631383 @default.
• W2149861331 cites W2106345381 @default.
• W2149861331 cites W2111482014 @default.
• W2149861331 cites W2115904158 @default.
• W2149861331 cites W2120191409 @default.
• W2149861331 cites W2121278592 @default.
• W2149861331 cites W2124091270 @default.
• W2149861331 cites W2129323416 @default.
• W2149861331 cites W2132576927 @default.
• W2149861331 cites W2133097088 @default.
• W2149861331 cites W2139192127 @default.
• W2149861331 cites W2140187466 @default.
• W2149861331 cites W2140965732 @default.
• W2149861331 cites W2151750517 @default.
• W2149861331 cites W2161925559 @default.
• W2149861331 cites W2161975833 @default.
• W2149861331 cites W2165293127 @default.
• W2149861331 cites W2171880393 @default.
• W2149861331 cites W2182746954 @default.
• W2149861331 cites W2185758919 @default.
• W2149861331 cites W2345769412 @default.
• W2149861331 doi "https://doi.org/10.1172/jci30485" @default.
• W2149861331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1978419" @default.
• W2149861331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17885686" @default.
• W2149861331 hasPublicationYear "2007" @default.
• W2149861331 type Work @default.
• W2149861331 sameAs 2149861331 @default.
• W2149861331 citedByCount "111" @default.
• W2149861331 countsByYear W21498613312012 @default.
• W2149861331 countsByYear W21498613312013 @default.
• W2149861331 countsByYear W21498613312014 @default.
• W2149861331 countsByYear W21498613312015 @default.
• W2149861331 countsByYear W21498613312016 @default.
• W2149861331 countsByYear W21498613312017 @default.
• W2149861331 countsByYear W21498613312018 @default.
• W2149861331 countsByYear W21498613312019 @default.
• W2149861331 countsByYear W21498613312020 @default.
• W2149861331 countsByYear W21498613312021 @default.
• W2149861331 countsByYear W21498613312022 @default.
• W2149861331 crossrefType "journal-article" @default.
• W2149861331 hasAuthorship W2149861331A5011065536 @default.
• W2149861331 hasAuthorship W2149861331A5013965800 @default.
• W2149861331 hasAuthorship W2149861331A5021974562 @default.
• W2149861331 hasAuthorship W2149861331A5052624003 @default.
• W2149861331 hasAuthorship W2149861331A5066294981 @default.
• W2149861331 hasAuthorship W2149861331A5073819497 @default.
• W2149861331 hasBestOaLocation W21498613311 @default.
• W2149861331 hasConcept C104317684 @default.
• W2149861331 hasConcept C110459506 @default.
• W2149861331 hasConcept C149011108 @default.
• W2149861331 hasConcept C185592680 @default.
• W2149861331 hasConcept C200082930 @default.
• W2149861331 hasConcept C202751555 @default.
• W2149861331 hasConcept C2776448209 @default.
• W2149861331 hasConcept C2777704780 @default.
• W2149861331 hasConcept C2777895019 @default.
• W2149861331 hasConcept C2778163477 @default.
• W2149861331 hasConcept C2779244956 @default.
• W2149861331 hasConcept C2780072125 @default.
• W2149861331 hasConcept C41443022 @default.
• W2149861331 hasConcept C43554185 @default.
• W2149861331 hasConcept C55493867 @default.

• next