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- W2149866248 abstract "Elevated oxidative capacity, such as occurs via endurance exercise training, is believed to protect against the development of obesity and diabetes. Rats bred both for low (LCR)- and high (HCR)-capacity endurance running provide a genetic model with inherent differences in aerobic capacity that allows for the testing of this supposition without the confounding effects of a training stimulus. The purpose of this investigation was to determine the effects of a high-fat diet (HFD) on weight gain patterns, insulin sensitivity, and fatty acid oxidative capacity in LCR and HCR male rats in the untrained state. Results indicate chow-fed LCR rats were heavier, hypertriglyceridemic, less insulin sensitive, and had lower skeletal muscle oxidative capacity compared with HCR rats. Upon exposure to an HFD, LCR rats gained more weight and fat mass, and their insulin resistant condition was exacerbated, despite consuming similar amounts of metabolizable energy as chow-fed controls. These metabolic variables remained unaltered in HCR rats. The HFD increased skeletal muscle oxidative capacity similarly in both strains, whereas hepatic oxidative capacity was diminished only in LCR rats. These results suggest that LCR rats are predisposed to obesity and that expansion of skeletal muscle oxidative capacity does not prevent excess weight gain or the exacerbation of insulin resistance on an HFD. Elevated basal skeletal muscle oxidative capacity and the ability to preserve liver oxidative capacity may protect HCR rats from HFD-induced obesity and insulin resistance." @default.
- W2149866248 created "2016-06-24" @default.
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- W2149866248 date "2007-07-01" @default.
- W2149866248 modified "2023-10-17" @default.
- W2149866248 title "Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance" @default.
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- W2149866248 cites W1860988726 @default.
- W2149866248 cites W1905920866 @default.
- W2149866248 cites W1949014864 @default.
- W2149866248 cites W1963586631 @default.
- W2149866248 cites W1963792814 @default.
- W2149866248 cites W1964172387 @default.
- W2149866248 cites W1965264273 @default.
- W2149866248 cites W1967964480 @default.
- W2149866248 cites W1968715224 @default.
- W2149866248 cites W1971452427 @default.
- W2149866248 cites W1972079136 @default.
- W2149866248 cites W1975390269 @default.
- W2149866248 cites W1979252938 @default.
- W2149866248 cites W1981261500 @default.
- W2149866248 cites W1990681455 @default.
- W2149866248 cites W1991694904 @default.
- W2149866248 cites W2007565715 @default.
- W2149866248 cites W2007665970 @default.
- W2149866248 cites W2014262736 @default.
- W2149866248 cites W2015068531 @default.
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- W2149866248 cites W2028316090 @default.
- W2149866248 cites W2028871457 @default.
- W2149866248 cites W2033874810 @default.
- W2149866248 cites W2034109892 @default.
- W2149866248 cites W2049481764 @default.
- W2149866248 cites W2051710927 @default.
- W2149866248 cites W2053859498 @default.
- W2149866248 cites W2054885202 @default.
- W2149866248 cites W2056174642 @default.
- W2149866248 cites W2058516879 @default.
- W2149866248 cites W2065034018 @default.
- W2149866248 cites W2069579647 @default.
- W2149866248 cites W2077427479 @default.
- W2149866248 cites W2077620470 @default.
- W2149866248 cites W2089471108 @default.
- W2149866248 cites W2091677067 @default.
- W2149866248 cites W2091759162 @default.
- W2149866248 cites W2098660920 @default.
- W2149866248 cites W2106693109 @default.
- W2149866248 cites W2106979999 @default.
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- W2149866248 cites W2115435380 @default.
- W2149866248 cites W2115951150 @default.
- W2149866248 cites W2116843182 @default.
- W2149866248 cites W2120537811 @default.
- W2149866248 cites W2121496639 @default.
- W2149866248 cites W2123106337 @default.
- W2149866248 cites W2126420509 @default.
- W2149866248 cites W2137046761 @default.
- W2149866248 cites W2138553207 @default.
- W2149866248 cites W2143541002 @default.
- W2149866248 cites W2146798664 @default.
- W2149866248 cites W2153169798 @default.
- W2149866248 cites W2154768987 @default.
- W2149866248 cites W2165052328 @default.
- W2149866248 cites W2165096496 @default.
- W2149866248 cites W2165886858 @default.
- W2149866248 cites W2174236669 @default.
- W2149866248 cites W2280634793 @default.
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- W2149866248 cites W3122152400 @default.
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- W2149866248 doi "https://doi.org/10.1152/ajpendo.00500.2006" @default.
- W2149866248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17341547" @default.
- W2149866248 hasPublicationYear "2007" @default.
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