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- W2149878776 abstract "The 96-kDa glycoprotein (gp96) is an endoplasmic reticulum (ER) resident molecular chaperone. Under physiologic conditions, gp96 facilitates the transport of toll-like receptors (TLRs) to cell or endosomal membranes. Under pathologic circumstances such as rheumatoid arthritis, gp96 translocates to the cell surface and extracellular space, serving as an endogenous danger signal promoting TLR signaling. Macrophages play a central role in regulating innate and adaptive immunity, and are the major source of proinflammatory cytokines and chemokines in rheumatoid arthritis (RA). Macrophage numbers in the sublining of RA synovial tissue correlate with clinical response. This review focuses on the recent findings that implicate gp96 induced macrophage activation mediated through TLR signaling in the pathogenesis of RA and provides insights concerning the targeting gp96 and the TLR signaling pathway as therapeutic approaches for patients with RA and possibly other chronic inflammatory conditions." @default.
- W2149878776 created "2016-06-24" @default.
- W2149878776 creator A5049221317 @default.
- W2149878776 creator A5062155931 @default.
- W2149878776 date "2013-02-01" @default.
- W2149878776 modified "2023-09-23" @default.
- W2149878776 title "The role of glycoprotein 96 in the persistent inflammation of rheumatoid arthritis" @default.
- W2149878776 cites W1508237796 @default.
- W2149878776 cites W1518183262 @default.
- W2149878776 cites W1530717069 @default.
- W2149878776 cites W1567327455 @default.
- W2149878776 cites W1579696447 @default.
- W2149878776 cites W1590068435 @default.
- W2149878776 cites W1594381485 @default.
- W2149878776 cites W1607689059 @default.
- W2149878776 cites W1613884642 @default.
- W2149878776 cites W1764690254 @default.
- W2149878776 cites W1963960661 @default.
- W2149878776 cites W1967418148 @default.
- W2149878776 cites W1967601848 @default.
- W2149878776 cites W1970304016 @default.
- W2149878776 cites W1971521446 @default.
- W2149878776 cites W1974276156 @default.
- W2149878776 cites W1977334392 @default.
- W2149878776 cites W1978025330 @default.
- W2149878776 cites W1979239025 @default.
- W2149878776 cites W1982564040 @default.
- W2149878776 cites W1983419107 @default.
- W2149878776 cites W1983890801 @default.
- W2149878776 cites W1987383242 @default.
- W2149878776 cites W1991731944 @default.
- W2149878776 cites W1991987254 @default.
- W2149878776 cites W1993525477 @default.
- W2149878776 cites W1995744610 @default.
- W2149878776 cites W1997344803 @default.
- W2149878776 cites W1998542103 @default.
- W2149878776 cites W2003801319 @default.
- W2149878776 cites W2005570998 @default.
- W2149878776 cites W2006223248 @default.
- W2149878776 cites W2011958996 @default.
- W2149878776 cites W2016430217 @default.
- W2149878776 cites W2016520544 @default.
- W2149878776 cites W2023910122 @default.
- W2149878776 cites W2025785916 @default.
- W2149878776 cites W2029431941 @default.
- W2149878776 cites W2037299442 @default.
- W2149878776 cites W2040390440 @default.
- W2149878776 cites W2040781140 @default.
- W2149878776 cites W2046429196 @default.
- W2149878776 cites W2049907045 @default.
- W2149878776 cites W2054732430 @default.
- W2149878776 cites W2061163173 @default.
- W2149878776 cites W2073063750 @default.
- W2149878776 cites W2073204639 @default.
- W2149878776 cites W2074438676 @default.
- W2149878776 cites W2077173577 @default.
- W2149878776 cites W2089400513 @default.
- W2149878776 cites W2090013658 @default.
- W2149878776 cites W2094605832 @default.
- W2149878776 cites W2096966529 @default.
- W2149878776 cites W2098940800 @default.
- W2149878776 cites W2102403552 @default.
- W2149878776 cites W2103533975 @default.
- W2149878776 cites W2104206929 @default.
- W2149878776 cites W2104209182 @default.
- W2149878776 cites W2104692415 @default.
- W2149878776 cites W2110115628 @default.
- W2149878776 cites W2110826367 @default.
- W2149878776 cites W2116393881 @default.
- W2149878776 cites W2123665246 @default.
- W2149878776 cites W2133272239 @default.
- W2149878776 cites W2133288737 @default.
- W2149878776 cites W2133500662 @default.
- W2149878776 cites W2135242029 @default.
- W2149878776 cites W2137901656 @default.
- W2149878776 cites W2138960096 @default.
- W2149878776 cites W2145241445 @default.
- W2149878776 cites W2147168728 @default.
- W2149878776 cites W2149446273 @default.
- W2149878776 cites W2152702111 @default.
- W2149878776 cites W2156724379 @default.
- W2149878776 cites W2163443542 @default.
- W2149878776 cites W2163576667 @default.
- W2149878776 cites W2165903162 @default.
- W2149878776 cites W2171714987 @default.
- W2149878776 cites W4211019157 @default.
- W2149878776 cites W66185433 @default.
- W2149878776 doi "https://doi.org/10.1016/j.abb.2012.12.008" @default.
- W2149878776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3558611" @default.
- W2149878776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23257071" @default.
- W2149878776 hasPublicationYear "2013" @default.
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