Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149881105> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2149881105 endingPage "2892" @default.
- W2149881105 startingPage "2889" @default.
- W2149881105 abstract "Activation of the phosphoinositide 3-kinase (PI3K)/Akt cell survival pathway in many cancers makes it an appealing target for therapeutic development. However, because this pathway also has an important role in the survival of normal cells, tactics to achieve cancer selectivity may prove important. We recently showed that the cancer-selective proapoptotic protein Par-4 is a key target for inactivation by PI3K/Akt signaling. Additionally, we found that Par-4 participates in mediating apoptosis by PTEN, the tumor suppressor responsible for blocking PI3K/Akt signaling. As a central player in cancer cell survival, Par-4 may provide a useful focus for the development of cancer-selective therapeutics." @default.
- W2149881105 created "2016-06-24" @default.
- W2149881105 creator A5040798103 @default.
- W2149881105 creator A5043352981 @default.
- W2149881105 creator A5074300281 @default.
- W2149881105 date "2006-03-15" @default.
- W2149881105 modified "2023-09-25" @default.
- W2149881105 title "The Phosphoinositide 3-Kinase/Akt1/Par-4 Axis: A Cancer-Selective Therapeutic Target" @default.
- W2149881105 cites W1502076440 @default.
- W2149881105 cites W1796435846 @default.
- W2149881105 cites W2008167035 @default.
- W2149881105 cites W2034269086 @default.
- W2149881105 cites W2039885900 @default.
- W2149881105 cites W2071630684 @default.
- W2149881105 cites W2081994535 @default.
- W2149881105 cites W2090495311 @default.
- W2149881105 cites W2094957750 @default.
- W2149881105 cites W2103173512 @default.
- W2149881105 cites W2110211384 @default.
- W2149881105 cites W2147114673 @default.
- W2149881105 cites W2166921147 @default.
- W2149881105 cites W2322768926 @default.
- W2149881105 cites W2333279736 @default.
- W2149881105 cites W2388163742 @default.
- W2149881105 cites W4214918874 @default.
- W2149881105 doi "https://doi.org/10.1158/0008-5472.can-05-4458" @default.
- W2149881105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16540633" @default.
- W2149881105 hasPublicationYear "2006" @default.
- W2149881105 type Work @default.
- W2149881105 sameAs 2149881105 @default.
- W2149881105 citedByCount "86" @default.
- W2149881105 countsByYear W21498811052012 @default.
- W2149881105 countsByYear W21498811052013 @default.
- W2149881105 countsByYear W21498811052014 @default.
- W2149881105 countsByYear W21498811052015 @default.
- W2149881105 countsByYear W21498811052016 @default.
- W2149881105 countsByYear W21498811052018 @default.
- W2149881105 countsByYear W21498811052019 @default.
- W2149881105 countsByYear W21498811052020 @default.
- W2149881105 countsByYear W21498811052021 @default.
- W2149881105 countsByYear W21498811052022 @default.
- W2149881105 crossrefType "journal-article" @default.
- W2149881105 hasAuthorship W2149881105A5040798103 @default.
- W2149881105 hasAuthorship W2149881105A5043352981 @default.
- W2149881105 hasAuthorship W2149881105A5074300281 @default.
- W2149881105 hasConcept C121608353 @default.
- W2149881105 hasConcept C154137905 @default.
- W2149881105 hasConcept C179185449 @default.
- W2149881105 hasConcept C184235292 @default.
- W2149881105 hasConcept C2777609662 @default.
- W2149881105 hasConcept C2781322055 @default.
- W2149881105 hasConcept C502942594 @default.
- W2149881105 hasConcept C54355233 @default.
- W2149881105 hasConcept C62478195 @default.
- W2149881105 hasConcept C75217442 @default.
- W2149881105 hasConcept C86554907 @default.
- W2149881105 hasConcept C86803240 @default.
- W2149881105 hasConcept C95444343 @default.
- W2149881105 hasConcept C96232424 @default.
- W2149881105 hasConceptScore W2149881105C121608353 @default.
- W2149881105 hasConceptScore W2149881105C154137905 @default.
- W2149881105 hasConceptScore W2149881105C179185449 @default.
- W2149881105 hasConceptScore W2149881105C184235292 @default.
- W2149881105 hasConceptScore W2149881105C2777609662 @default.
- W2149881105 hasConceptScore W2149881105C2781322055 @default.
- W2149881105 hasConceptScore W2149881105C502942594 @default.
- W2149881105 hasConceptScore W2149881105C54355233 @default.
- W2149881105 hasConceptScore W2149881105C62478195 @default.
- W2149881105 hasConceptScore W2149881105C75217442 @default.
- W2149881105 hasConceptScore W2149881105C86554907 @default.
- W2149881105 hasConceptScore W2149881105C86803240 @default.
- W2149881105 hasConceptScore W2149881105C95444343 @default.
- W2149881105 hasConceptScore W2149881105C96232424 @default.
- W2149881105 hasIssue "6" @default.
- W2149881105 hasLocation W21498811051 @default.
- W2149881105 hasLocation W21498811052 @default.
- W2149881105 hasOpenAccess W2149881105 @default.
- W2149881105 hasPrimaryLocation W21498811051 @default.
- W2149881105 hasRelatedWork W2028251054 @default.
- W2149881105 hasRelatedWork W2149881105 @default.
- W2149881105 hasRelatedWork W2530477428 @default.
- W2149881105 hasRelatedWork W2552099953 @default.
- W2149881105 hasRelatedWork W2729490154 @default.
- W2149881105 hasRelatedWork W2753273667 @default.
- W2149881105 hasRelatedWork W2861688776 @default.
- W2149881105 hasRelatedWork W2986129865 @default.
- W2149881105 hasRelatedWork W3159932768 @default.
- W2149881105 hasRelatedWork W4313594830 @default.
- W2149881105 hasVolume "66" @default.
- W2149881105 isParatext "false" @default.
- W2149881105 isRetracted "false" @default.
- W2149881105 magId "2149881105" @default.
- W2149881105 workType "article" @default.