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• W2149882617 abstract "Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell. Probably, the most significant is the change to the structure of the spindle that leads to increased numbers of spindle poles and abnormal partitioning of the chromosomes in mitosis. I address how centrosomal changes are initiated and how they may lead to spindle multipolarity." @default.
• W2149882617 created "2016-06-24" @default.
• W2149882617 creator A5057686891 @default.
• W2149882617 date "2005-02-01" @default.
• W2149882617 modified "2023-09-25" @default.
• W2149882617 title "Centrosomal amplification and spindle multipolarity in cancer cells" @default.
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• W2149882617 doi "https://doi.org/10.1016/j.semcancer.2004.09.003" @default.
• W2149882617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15613285" @default.
• W2149882617 hasPublicationYear "2005" @default.
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