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- W2149895384 abstract "NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still poorly understood. Recently, proteins of the tripartite motif (TRIM) protein family have emerged as regulators of innate immune responses by acting as E3 ubiquitin ligases. We identified TRIM27 as a new specific binding partner for NOD2. We show that NOD2 physically interacts with TRIM27 via the nucleotide-binding domain, and that NOD2 activation enhances this interaction. Dependent on functional TRIM27, ectopically expressed NOD2 is ubiquitinated with K48-linked ubiquitin chains followed by proteasomal degradation. Accordingly, TRIM27 affects NOD2-mediated pro-inflammatory responses. NOD2 mutations are linked to susceptibility to Crohn's disease. We found that TRIM27 expression is increased in Crohn's disease patients, underscoring a physiological role of TRIM27 in regulating NOD2 signaling. In HeLa cells, TRIM27 is partially localized in the nucleus. We revealed that ectopically expressed NOD2 can shuttle to the nucleus in a Walker A dependent manner, suggesting that NOD2 and TRIM27 might functionally cooperate in the nucleus. We conclude that TRIM27 negatively regulates NOD2-mediated signaling by degradation of NOD2 and suggest that TRIM27 could be a new target for therapeutic intervention in NOD2-associated diseases." @default.
- W2149895384 created "2016-06-24" @default.
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- W2149895384 date "2012-07-19" @default.
- W2149895384 modified "2023-10-16" @default.
- W2149895384 title "TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation" @default.
- W2149895384 cites W1536422556 @default.
- W2149895384 cites W1629239351 @default.
- W2149895384 cites W1904832534 @default.
- W2149895384 cites W1951864429 @default.
- W2149895384 cites W1970589808 @default.
- W2149895384 cites W1974781808 @default.
- W2149895384 cites W1981221573 @default.
- W2149895384 cites W1984750489 @default.
- W2149895384 cites W1991808732 @default.
- W2149895384 cites W1992225327 @default.
- W2149895384 cites W1992226252 @default.
- W2149895384 cites W1996095649 @default.
- W2149895384 cites W1996631006 @default.
- W2149895384 cites W2004684128 @default.
- W2149895384 cites W2008200326 @default.
- W2149895384 cites W2009269143 @default.
- W2149895384 cites W2009364588 @default.
- W2149895384 cites W2011580988 @default.
- W2149895384 cites W2015969841 @default.
- W2149895384 cites W2016264506 @default.
- W2149895384 cites W2019243957 @default.
- W2149895384 cites W2022480880 @default.
- W2149895384 cites W2033417059 @default.
- W2149895384 cites W2033698154 @default.
- W2149895384 cites W2033702347 @default.
- W2149895384 cites W2036465717 @default.
- W2149895384 cites W2040211909 @default.
- W2149895384 cites W2041170922 @default.
- W2149895384 cites W2043667001 @default.
- W2149895384 cites W2046346290 @default.
- W2149895384 cites W2047580079 @default.
- W2149895384 cites W2050798656 @default.
- W2149895384 cites W2052127995 @default.
- W2149895384 cites W2053847949 @default.
- W2149895384 cites W2067706259 @default.
- W2149895384 cites W2071993841 @default.
- W2149895384 cites W2073044944 @default.
- W2149895384 cites W2074740959 @default.
- W2149895384 cites W2082613707 @default.
- W2149895384 cites W2083300694 @default.
- W2149895384 cites W2086607027 @default.
- W2149895384 cites W2088474515 @default.
- W2149895384 cites W2088895400 @default.
- W2149895384 cites W2089370030 @default.
- W2149895384 cites W2089380674 @default.
- W2149895384 cites W2089816345 @default.
- W2149895384 cites W2090282670 @default.
- W2149895384 cites W2094129507 @default.
- W2149895384 cites W2095058565 @default.
- W2149895384 cites W2095766576 @default.
- W2149895384 cites W2095963321 @default.
- W2149895384 cites W2097035469 @default.
- W2149895384 cites W2099873437 @default.
- W2149895384 cites W2103790202 @default.
- W2149895384 cites W2105249930 @default.
- W2149895384 cites W2110372095 @default.
- W2149895384 cites W2112762103 @default.
- W2149895384 cites W2113573651 @default.
- W2149895384 cites W2113707064 @default.
- W2149895384 cites W2114097399 @default.
- W2149895384 cites W2116773729 @default.
- W2149895384 cites W2120957859 @default.
- W2149895384 cites W2129691636 @default.
- W2149895384 cites W2133006561 @default.
- W2149895384 cites W2135099287 @default.
- W2149895384 cites W2135140747 @default.
- W2149895384 cites W2137499315 @default.
- W2149895384 cites W2138626623 @default.
- W2149895384 cites W2139849597 @default.
- W2149895384 cites W2144114582 @default.
- W2149895384 cites W2144646233 @default.
- W2149895384 cites W2151713498 @default.
- W2149895384 cites W2152765142 @default.
- W2149895384 cites W2152806961 @default.
- W2149895384 cites W2152892875 @default.
- W2149895384 cites W2153130127 @default.
- W2149895384 cites W2155025594 @default.
- W2149895384 cites W2160790198 @default.
- W2149895384 cites W2162800927 @default.
- W2149895384 cites W2166105696 @default.
- W2149895384 cites W2166987747 @default.
- W2149895384 cites W2182301246 @default.