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- W2149899666 abstract "ABSTRACT Inactivation of hemB in Staphylococcus aureus strain Newman resulted in a small-colony phenotype and was accompanied by an altered expression pattern of global regulators and control of virulence factor production. Transcription profiles followed over 15 h by Northern blot analyses revealed that transcripts of the global regulators arl , rot , sae , sarR , sarS , srr , svrA , and sigB disappeared after the exponential phase and that both agr transcripts were completely absent in the hemB mutant. Apart from a general concentration of transcriptional activity to the exponential phase, premature gene expression was observed for rot , hla , and spa . Nevertheless, reported σ B -dependent transcripts, such as sarC and clfA , were produced throughout the 15-h growth period monitored. The absence of these transcripts in a hemB sigB double mutant demonstrated their dependence on σ B and indicated an unexpected, permanent σ B activity in the hemB mutant. Variations in the extents of the directly σ B -controlled asp23 , rsbVW-sigB , and sarC transcripts argue for additional factors modulating σ B activity. This study provides the first extended synopsis of the transcriptional patterns of different regulators over the entire growth cycle in the widely used Newman strain." @default.
- W2149899666 created "2016-06-24" @default.
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- W2149899666 creator A5069518872 @default.
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- W2149899666 date "2005-11-01" @default.
- W2149899666 modified "2023-09-25" @default.
- W2149899666 title "σ B Activity in a Staphylococcus aureus hemB Mutant" @default.
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- W2149899666 doi "https://doi.org/10.1128/jb.187.21.7397-7406.2005" @default.
- W2149899666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1272976" @default.
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