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- W2149899785 abstract "BACKGROUNDInactivation of the maternally or paternally derived X chromosome (XCI) initially occurs in a random manner in early development; however as tissues form, a ‘patchiness’ will occur in terms of which X is inactivated if cells positioned near each other are clonally descended from a common precursor. Determining the relationship between skewed XCI in different tissues and in different samples from the same tissue provides a molecular assessment of the developmental history of a particular tissue that can then be used to understand how genetic and epigenetic variation arises in development." @default.
- W2149899785 created "2016-06-24" @default.
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- W2149899785 date "2012-03-19" @default.
- W2149899785 modified "2023-10-16" @default.
- W2149899785 title "Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation" @default.
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- W2149899785 doi "https://doi.org/10.1093/humrep/des072" @default.
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