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• W2149900813 abstract "ABSTRACT Vaccination with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune response in mice. We explored the cellular and molecular requirements for the efficacy of recombinant Hsp60 in mice. Depletion of CD4 + , but not CD8 + , cells during the inductive phase of vaccination abolished protection, as assessed by survival and by the fungal burden in lungs and spleens. In the expressive phase, the elimination of CD4 + or CD8 + cells after immunization did not significantly alter fungal recovery or survival from a lethal challenge. Depletion of both subpopulations after Hsp60 vaccination resulted in a failure to control a lethal infection and a higher fungal burden in lungs and spleens. Cytokine release by spleen cells from mice vaccinated with Hsp60 produced substantially more gamma interferon and interleukin-10 and -12 than that of cells from mice immunized with either H. capsulatum recombinant Hsp70 or bovine serum albumin. The generation of gamma interferon, but not of interleukin-10, was dependent on T cells, in particular CD4 + cells. Treatment of Hsp60-immunized mice with monoclonal antibody to gamma interferon or interleukin-10 or -12 in the inductive phase of vaccination was accompanied by increased recovery of yeast cells from lungs and spleens and 100% mortality. Likewise, the neutralization of gamma interferon or interleukin-12 abolished the protective effect of Hsp60 in the expressive phase. These results delineate the complexity of the regulatory elements necessary for vaccination against this fungus." @default.
• W2149900813 created "2016-06-24" @default.
• W2149900813 creator A5018697225 @default.
• W2149900813 creator A5057793398 @default.
• W2149900813 date "2002-07-01" @default.
• W2149900813 modified "2023-10-18" @default.
• W2149900813 title "Cellular and Molecular Regulation of Vaccination with Heat Shock Protein 60 from<i>Histoplasma capsulatum</i>" @default.
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• W2149900813 doi "https://doi.org/10.1128/iai.70.7.3759-3767.2002" @default.
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