FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149928982> ?p ?o ?g. }

• W2149928982 endingPage "211" @default.
• W2149928982 startingPage "203" @default.
• W2149928982 abstract "Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a highly significant role in neurodegenerative diseases, CNS trauma, as well as psychiatric disease and have become a target for small molecule and biologic therapies. We report the development of a method for measuring pharmacodynamic changes induced by potential CNS therapeutics using nasal olfactory neural tissue biopsy. We validated this approach using a potential astrocyte-targeted therapeutic, thiamphenicol, in a pre-clinical rodent study as well as a phase 1 human trial. In both settings, analysis of the olfactory epithelial tissue revealed biological activity of thiamphenicol at the drug target, the excitatory amino acid transporter 2 (EAAT2). Therefore, this biomarker approach may provide a reliable evaluation of CNS glial-directed therapies and hopefully improve throughput for nervous system drug discovery." @default.
• W2149928982 created "2016-06-24" @default.
• W2149928982 creator A5002880246 @default.
• W2149928982 creator A5045098375 @default.
• W2149928982 creator A5045835481 @default.
• W2149928982 creator A5069018183 @default.
• W2149928982 creator A5076889746 @default.
• W2149928982 creator A5083878416 @default.
• W2149928982 creator A5089087983 @default.
• W2149928982 date "2011-12-01" @default.
• W2149928982 modified "2023-10-16" @default.
• W2149928982 title "Human nasal olfactory epithelium as a dynamic marker for CNS therapy development" @default.
• W2149928982 cites W1698458799 @default.
• W2149928982 cites W1964670881 @default.
• W2149928982 cites W1971395905 @default.
• W2149928982 cites W1971639674 @default.
• W2149928982 cites W1971948864 @default.
• W2149928982 cites W1972162063 @default.
• W2149928982 cites W1972320412 @default.
• W2149928982 cites W1975464681 @default.
• W2149928982 cites W1976130596 @default.
• W2149928982 cites W1978723069 @default.
• W2149928982 cites W1979378430 @default.
• W2149928982 cites W1980996290 @default.
• W2149928982 cites W1983601261 @default.
• W2149928982 cites W1990407178 @default.
• W2149928982 cites W1992490299 @default.
• W2149928982 cites W1993064034 @default.
• W2149928982 cites W1996589674 @default.
• W2149928982 cites W1996835497 @default.
• W2149928982 cites W2003410399 @default.
• W2149928982 cites W2004331086 @default.
• W2149928982 cites W2004843852 @default.
• W2149928982 cites W2005864274 @default.
• W2149928982 cites W2011537498 @default.
• W2149928982 cites W2012789218 @default.
• W2149928982 cites W2013377604 @default.
• W2149928982 cites W2021542157 @default.
• W2149928982 cites W2025823788 @default.
• W2149928982 cites W2026922418 @default.
• W2149928982 cites W2030158363 @default.
• W2149928982 cites W2040017472 @default.
• W2149928982 cites W2040760020 @default.
• W2149928982 cites W2045996940 @default.
• W2149928982 cites W2047175748 @default.
• W2149928982 cites W2050648377 @default.
• W2149928982 cites W2052935486 @default.
• W2149928982 cites W2054588014 @default.
• W2149928982 cites W2058990053 @default.
• W2149928982 cites W2068147651 @default.
• W2149928982 cites W2072470634 @default.
• W2149928982 cites W2074907255 @default.
• W2149928982 cites W2075088721 @default.
• W2149928982 cites W2082363371 @default.
• W2149928982 cites W2082544214 @default.
• W2149928982 cites W2083204774 @default.
• W2149928982 cites W2084094166 @default.
• W2149928982 cites W2089157578 @default.
• W2149928982 cites W2091708438 @default.
• W2149928982 cites W2092034907 @default.
• W2149928982 cites W2092544119 @default.
• W2149928982 cites W2094920961 @default.
• W2149928982 cites W2098370542 @default.
• W2149928982 cites W2128744963 @default.
• W2149928982 cites W2129102784 @default.
• W2149928982 cites W2149497936 @default.
• W2149928982 cites W2154549928 @default.
• W2149928982 cites W2166972019 @default.
• W2149928982 cites W2171233186 @default.
• W2149928982 cites W4210979710 @default.
• W2149928982 doi "https://doi.org/10.1016/j.expneurol.2011.09.002" @default.
• W2149928982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3220936" @default.
• W2149928982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21945230" @default.
• W2149928982 hasPublicationYear "2011" @default.
• W2149928982 type Work @default.
• W2149928982 sameAs 2149928982 @default.
• W2149928982 citedByCount "20" @default.
• W2149928982 countsByYear W21499289822012 @default.
• W2149928982 countsByYear W21499289822013 @default.
• W2149928982 countsByYear W21499289822014 @default.
• W2149928982 countsByYear W21499289822015 @default.
• W2149928982 countsByYear W21499289822016 @default.
• W2149928982 countsByYear W21499289822017 @default.
• W2149928982 countsByYear W21499289822018 @default.
• W2149928982 countsByYear W21499289822019 @default.
• W2149928982 countsByYear W21499289822021 @default.
• W2149928982 countsByYear W21499289822022 @default.
• W2149928982 countsByYear W21499289822023 @default.
• W2149928982 crossrefType "journal-article" @default.
• W2149928982 hasAuthorship W2149928982A5002880246 @default.
• W2149928982 hasAuthorship W2149928982A5045098375 @default.
• W2149928982 hasAuthorship W2149928982A5045835481 @default.
• W2149928982 hasAuthorship W2149928982A5069018183 @default.
• W2149928982 hasAuthorship W2149928982A5076889746 @default.
• W2149928982 hasAuthorship W2149928982A5083878416 @default.
• W2149928982 hasAuthorship W2149928982A5089087983 @default.
• W2149928982 hasBestOaLocation W21499289822 @default.
• W2149928982 hasConcept C169760540 @default.

• next