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• W2149930817 abstract "El diagnóstico de las enfermedades inflamatorias intestinales se ha basado, clásicamente, en la valoración de síntomas digestivos. Su aparición suele resultar en una colonoscopia, cuyo rendimiento es bajo. Asimismo, existe una tendencia creciente en fundamentar el tratamiento de la enfermedad inflamatoria intestinal en datos objetivos, ya que la desaparición de los signos de actividad en la colonoscopia (denominada «curación mucosa») se ha relacionado con una remisión clínica sostenida y una reducción en la tasa de hospitalización y cirugía. En consecuencia, es necesario identificar biomarcadores que permitan seleccionar aquellos pacientes que van a beneficiarse más de una exploración endoscópica. La calprotectina fecal ha sido propuesta como biomarcador de inflamación intestinal. Permite diferenciar la enfermedad inflamatoria intestinal del síndrome de intestino irritable, presenta una mejor correlación con el grado de inflamación que los índices clínicos y marcadores serológicos. Además, podría ser útil para predecir la curación mucosa y el riesgo de recidiva. The diagnosis of inflammatory bowel diseases has classically been based on assessment of digestive symptoms. The development of these symptoms usually results in colonoscopy, which has a low diagnostic yield. Likewise, there is an increasing tendency to base treatment of inflammatory bowel disease on objective data, since the disappearance of signs of activity on colonoscopy (called «mucosal cure») has been associated with sustained clinical remission and reduced rates of hospitalization and surgery. Consequently, there is a need for biomarkers that would aid the selection of those patients who would derive most benefit from an endoscopic examination. One substance that has been proposed as a biomarker of bowel inflammation is fecal calprotectin. This substance allows inflammatory bowel disease to be distinguished from irritable bowel syndrome and shows a better correlation with the degree of inflammation than clinical indicators and serological markers. In addition, it could also be useful to predict mucosal cure and the risk of recurrence." @default.
• W2149930817 created "2016-06-24" @default.
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• W2149930817 creator A5049038548 @default.
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• W2149930817 date "2013-06-01" @default.
• W2149930817 modified "2023-10-16" @default.
• W2149930817 title "Calprotectina fecal en el diagnóstico de enfermedades inflamatorias" @default.
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• W2149930817 doi "https://doi.org/10.1016/j.gastrohep.2012.10.008" @default.
• W2149930817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23434080" @default.
• W2149930817 hasPublicationYear "2013" @default.
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