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• W2149952796 abstract "Intercellular transfer of proteins is a mode of communication between cells that is crucial for certain physiological processes. Chemotherapy is the treatment of choice for ∼50% of all cancers. However, multidrug resistance mediated by drug-efflux pumps such as P-glycoprotein (Pgp) minimizes the effectiveness of such therapy in a large number of patients. A new study demonstrates the functional intercellular transfer of Pgp. Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits. Intercellular transfer of proteins is a mode of communication between cells that is crucial for certain physiological processes. Chemotherapy is the treatment of choice for ∼50% of all cancers. However, multidrug resistance mediated by drug-efflux pumps such as P-glycoprotein (Pgp) minimizes the effectiveness of such therapy in a large number of patients. A new study demonstrates the functional intercellular transfer of Pgp. Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits." @default.
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• W2149952796 date "2005-08-01" @default.
• W2149952796 modified "2023-10-11" @default.
• W2149952796 title "A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)" @default.
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• W2149952796 doi "https://doi.org/10.1016/j.tips.2005.06.001" @default.
• W2149952796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1350964" @default.
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