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• W2149953626 startingPage "R393" @default.
• W2149953626 abstract "The Apc(Min/+) mouse has a mutation in the Apc tumor suppressor gene and develops intestinal polyps, beginning at 4 wk of age. This mouse develops cachexia by 6 mo, characterized by significant loss of muscle and fat tissue. The purpose of the present study was to determine the role of circulating interleukin-6 (IL-6) and the polyp burden for the development of cachexia in Apc(Min/+) mice. At 26 wk of age, mice exhibiting severe cachectic symptoms had a 61% decrease in gastrocnemius muscle weight, complete loss of epididymal fat, a 10-fold increase in circulating IL-6 levels, and an 89% increase in intestinal polyps compared with mildly cachectic animals. Apc(Min/+)/IL-6(-/-) mice did not lose gastrocnemius muscle mass or epididymal fat pad mass while overall polyp number decreased by 32% compared with Apc(Min/+) mice. Plasmid-based IL-6 overexpression in Apc(Min/+)/IL-6(-/-) mice led to a decrease in gastrocnemius muscle mass and epididymal fat pad mass and increased intestinal polyp burden. IL-6 overexpression did not induce cachexia in non-tumor-bearing mice. These data demonstrate that IL-6 is necessary for the onset of adipose and skeletal muscle wasting in the Apc(Min/+) mouse and that circulating IL-6 can regulate Apc(Min/+) mouse tumor burden." @default.
• W2149953626 created "2016-06-24" @default.
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• W2149953626 date "2008-02-01" @default.
• W2149953626 modified "2023-09-26" @default.
• W2149953626 title "Interleukin-6 and cachexia in<i>Apc</i>^<i>Min/+</i>mice" @default.
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• W2149953626 doi "https://doi.org/10.1152/ajpregu.00716.2007" @default.
• W2149953626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18056981" @default.
• W2149953626 hasPublicationYear "2008" @default.
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